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Synthetic method of cyproconazole intermediate

A technology of cyproconazole and its synthesis method, which is applied in the field of chemistry and chemical engineering, can solve problems such as complex process, high economic cost, and high risk, and achieve the effects of high process fluency, high total reaction yield, and strong operability

Inactive Publication Date: 2016-11-09
YANCHENEG HUIHUANG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology offers technical benefits such as efficient processing time, safe handling during manufacturing processes, easy operation at lower costs compared with other methods like lithography or etching techniques for producing electronic components on silicon wafers. It also allows for higher yields than traditional chemicals used for these purposes due to its ability to react quickly without generating harmful byproducts that could be released into environmentally sensitive areas around it's location.

Problems solved by technology

This patented describes different ways for producing certain types of compounds called cyclomuccorol A or 2'-cyclodextrin B (CD). These molecules can be made through various techniques such as starting from specific substances like naphtha that have been modified into other ones. However these modifications require complex procedures involving multiple chemical agents, resulting in increased costs and safety concerns during manufacturing. Therefore there has also been an interest towards developing simpler and more efficient routes for CD formation without requiring significant changes in existing equipment.

Method used

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  • Synthetic method of cyproconazole intermediate
  • Synthetic method of cyproconazole intermediate
  • Synthetic method of cyproconazole intermediate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The synthesis of embodiment 1 compound (III)

[0029]

[0030] In a 500 ml single-necked bottle, add 56g (0.4mol) of p-chlorobenzaldehyde, 150g of toluene, 63.84g (0.84mol) of ethylene glycol methyl ether, and 1.72g (0.01mol) of p-toluenesulfonic acid, and reflux to separate water After 6 hours, triethylamine was added to adjust the pH=7-8, and the solvent was distilled off to obtain 108.2 g of compound (III), with a purity of 97.4% and a yield of 96.3%.

Embodiment 2

[0031] The synthesis of embodiment 2 compound (III)

[0032] In a 500 ml single-necked bottle, add 56g (0.2mol) of p-chlorobenzaldehyde, add 170g of benzene, add 63.84g (0.84mol) of ethylene glycol methyl ether, add 18.25g (0.01mol) of phosphomolybdic acid, reflux and divide water for 6 After 1 hour, triethylamine was added to adjust the pH=7-8, and the solvent was evaporated to obtain 104.9 g of compound (III), with a purity of 96.8% and a yield of 92.6%.

Embodiment 3

[0033] The synthesis of embodiment 3 compound (III)

[0034] In a 500 ml single-necked bottle, add 56g (0.2mol) of p-chlorobenzaldehyde, 180g of toluene, 63.84g (0.84mol) of ethylene glycol methyl ether, and 1.90g (0.01mol) of titanium tetrachloride, and reflux to separate water After 6 hours, triethylamine was added to adjust the pH to 7-8, and the solvent was evaporated to obtain 103.7 g of compound (III), with a purity of 96.4% and a yield of 91.2%.

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Abstract

The invention relates to a synthetic method of cyproconazole intermediate. The synthetic route is as follow (see the formula in the description). The method includes the steps that p-chlorobenzaldehyde is used as a raw material, an acetal intermediate is obtained through condensation of p-chlorobenzaldehyde and ethylene glycol monomethyl ether, by means of triethyl phosphite, the acetal intermediate reacts with cyclopropyl methyl ketone under the alkaline condition, and finally the target compound (I) is obtained through hydrolysis. The synthetic method has the advantages of being safe, convenient, smooth in process and suitable for industrial production.

Description

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Claims

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Application Information

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Owner YANCHENEG HUIHUANG CHEM
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