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Anti-adhesion flushing fluid for gynecological operation and preparation method thereof

A technology of gynecological surgery and flushing solution, which is applied in the field of surgical flushing solution, which can solve the problems of poor anti-adhesion effect and secondary diseases, achieve convenient storage, reduce side effects, and ensure the effect of osmotic pressure and pH value

Inactive Publication Date: 2016-12-07
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides an anti-adhesion flushing solution for gynecological surgery and a preparation method thereof, which solves the problem that the poor anti-adhesion effect of anti-abdominal adhesion drugs in the prior art easily leads to secondary diseases

Method used

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  • Anti-adhesion flushing fluid for gynecological operation and preparation method thereof
  • Anti-adhesion flushing fluid for gynecological operation and preparation method thereof

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preparation example Construction

[0021] A preparation method of anti-adhesion flushing solution for gynecological surgery of the present invention comprises the following steps: 1) adding prescription quantity of icodextrin, sodium chloride, sodium lactate, calcium chloride and magnesium chloride into the injection water of prescription quantity, Stir to dissolve to obtain a solution; 2) The solution obtained in step 1) is subjected to moist heat sterilization at a sterilization temperature of 121° C. and a sterilization time of 15-30 minutes to obtain a product.

[0022] Preferably, before step 2), the solution obtained in step 1) is passed through 5 μm and 0.45 μm filter elements and a return pipeline respectively, and circulated back for 20-30 minutes, and finally, filtered through a 0.22 μm filter element.

[0023] Specifically, the molecular weight of the icodextrin is 13000-19000 Daltons.

[0024] Further, the osmotic pressure of the product obtained in the step 2) is 270-280mOsm / L, the pH value is 6.5-...

Embodiment 1

[0026] A kind of preparation method of anti-adhesion flushing liquid for gynecological surgery of the present invention comprises the following steps:

[0027] 1) Weigh raw materials: icodextrin 40g, sodium chloride 5.4g, sodium lactate 4.5g, calcium chloride 0.257g, magnesium chloride 0.051g, water for injection 1000mL, water for injection in the present invention is water for injection;

[0028] 2) Add the above-mentioned icodextrin, sodium chloride, sodium lactate, calcium chloride, and magnesium chloride to the above-mentioned injection water in sequence, stir to dissolve, and obtain a solution;

[0029] 3) The above solution was sterilized by moist heat, the sterilization temperature was 121°C, and the sterilization time was 30 minutes to obtain the product.

Embodiment 2

[0031] A kind of preparation method of anti-adhesion flushing liquid for gynecological surgery of the present invention comprises the following steps:

[0032] 1) Weigh raw materials: icodextrin 50g, sodium chloride 6.5g, sodium lactate 4.0g, calcium chloride 0.1g, magnesium chloride 0.01g, water for injection 1000mL;

[0033] 2) Add the above-mentioned icodextrin, sodium chloride, sodium lactate, calcium chloride, and magnesium chloride to the above-mentioned injection water in sequence, stir to dissolve, and obtain a solution;

[0034] 3) The above solution was sterilized by moist heat, the sterilization temperature was 121°C, and the sterilization time was 15 minutes to obtain the product.

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Abstract

The invention discloses anti-adhesion flushing fluid for a gynecological operation and a preparation method thereof and belongs to the technical field of flushing fluid for operation. Every 1L of the flushing fluid disclosed by the invention is prepared from the following raw materials in grams by weight: 30-50g of icodextrin, 4.5-6.5g of sodium chloride, 0.1-0.5g of calcium chloride, 0.01-0.1g of magnesium chloride, 4.0-5.0g of sodium lactate and a proper amount of water for injection. The invention also provides a method for preparing the flushing fluid. According to the invention, an anti-adhesion effect of icodextrin is fully utilized, and the calcium ion, magnesium ion and sodium lactate are added; due to the addition of the calcium ion and magnesium ion, the antibacterial and bacteriostatic abilities are enhanced, and wound healing is promoted; the sodium lactate serves as a pH buffer agent, so that normal osmotic pressure and pH value in the abdominal cavity can be guaranteed, and side reactions are reduced; and moreover, the flushing fluid disclosed by the invention is high in stability, difficult to degrade and denature, good in flushing effect and anti-adhesion effect, non-irritating to skin and convenient to use.

Description

technical field [0001] The invention belongs to the technical field of surgical flushing liquid, in particular to an anti-adhesion flushing liquid for gynecological surgery and a preparation method thereof. Background technique [0002] Adhesions are abnormal attachments of tissue to tissue surfaces and are an exaggerated physiological response of the peritoneum to injury; adhesions are often beneficial as part of the wound healing process, however, adhesions are also a cause of small bowel obstruction, infertility, and chronic pelvic pain after gynecological surgery Important reasons; at the same time, it also increases the difficulty of reoperation for patients. Studies have shown that the visceral peritoneum (uterus, ovary, fallopian tube) is more prone to adhesions than the parietal peritoneum (pelvic cavity and abdominal cavity) after gynecological surgery, and 20% of secondary infertility is caused by adhesions; however, those who have undergone open gynecological surg...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P41/00A61K33/06A61K31/716A61K31/19
CPCA61K33/14A61K9/08A61K31/19A61K31/716A61K33/06A61K2300/00
Inventor 谢苗苗冯新光
Owner HUAREN PHARMACEUTICAL CO LTD
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