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A kind of Tongmai pharmaceutical composition and preparation method thereof

A technology for a composition and medicinal materials, applied in the field of medicine, can solve the problems of not being given, the composition is complex, etc., and achieve the effects of good drug efficacy, guaranteeing drug quality, and stable drug efficacy.

Active Publication Date: 2019-11-22
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of traditional Chinese medicine, especially compound Chinese medicine, is very complex, which means that the increase of the content of only three or five active ingredients may not necessarily improve the efficacy of the medicine, but the rational compatibility of each active ingredient (including trace ingredients) and the full play of synergistic effects are the key. The key to the improvement of drug efficacy, literature 3 does not give data on the drug efficacy of the products prepared by this method, so whether the products prepared by this method have clinical significance needs to be further verified

Method used

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  • A kind of Tongmai pharmaceutical composition and preparation method thereof
  • A kind of Tongmai pharmaceutical composition and preparation method thereof
  • A kind of Tongmai pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Party:

[0066] Salvia 100g Chuanxiong 100g Pueraria Root 100g

[0067] Preparation:

[0068] Weigh the medicinal materials of Salvia miltiorrhiza, decoct once with 800g of water for 1 hour, and then use 500g of water for 2 times for half an hour; combine the decoctions, cool to room temperature, filter, and add ethanol to make the alcohol-containing The amount reaches 80%, refrigerate, filter, and concentrate the filtrate to a relative density of 1.10-1.15 at a temperature of 60 ° C. The obtained concentrate is injected into HPD600 type macroporous adsorption resin column, wherein the diameter-height ratio of the macroporous adsorption resin column is 1:6, the elution conditions are: the weight ratio of Dan to dry resin is 4:1, the adsorption flow rate is 3ml / min, and the elution flow rate is 4ml / min. Then use 8 times the column volume of 20% ethanol to elute, discard the eluent, and then use 6 times the column volume of 75% ethanol to elute, and collect the 75% etha...

Embodiment 2

[0073] Party:

[0074] Salvia 100g Chuanxiong 100g Pueraria Root 100g

[0075] Preparation:

[0076] Weigh the medicinal materials of Salvia miltiorrhiza, decoct once with 800g of water for 1 hour, and then use 500g of water for 2 times for half an hour; combine the decoctions, cool to room temperature, filter, and add ethanol to make the alcohol-containing The amount reaches 80%, refrigerate, filter, and concentrate the filtrate to a relative density of 1.10-1.15 at a temperature of 60 ° C. The obtained concentrate is injected into HPD600 type macroporous adsorption resin column, wherein the diameter-height ratio of the macroporous adsorption resin column is 1:7, the elution conditions are: the weight ratio of Dan to dry resin is 4:1, the adsorption flow rate is 3ml / min, and the elution flow rate is 4ml / min; during elution, 8 times the column volume of purified water is used to elute, Then use 8 times the column volume of 20% ethanol to elute, discard the eluent, and then u...

Embodiment 3

[0081] Party:

[0082] Salvia 100g Chuanxiong 100g Pueraria Root 100g

[0083] Preparation:

[0084] Weigh the medicinal materials of Salvia miltiorrhiza, decoct once with 800g of water for 1 hour, and then use 500g of water for 2 times for half an hour; combine the decoctions, cool to room temperature, filter, and add ethanol to make the alcohol-containing The amount reaches 80%, refrigerate, filter, and concentrate the filtrate to a relative density of 1.10-1.15 at a temperature of 60 ° C. The obtained concentrate is injected into HPD600 type macroporous adsorption resin column, wherein the diameter-height ratio of the macroporous adsorption resin column is 1:8, the elution conditions are: the weight ratio of Dan to dry resin is 4:1, the adsorption flow rate is 3ml / min, and the elution flow rate is 4ml / min. Then use 8 times the column volume of 20% ethanol to elute, discard the eluent, and then use 6 times the column volume of 75% ethanol to elute, and collect the 75% ethano...

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Abstract

The invention relates to a pharmaceutical composition capable of treating ischemic cardiovascularand cerebrovascular diseases, arteriosclerosis, cerebral thrombosis, cerebral ischemia, coronary heart diseases and stenocardia and a preparation method thereof. The composition is prepared by taking 100 parts of salviae miltiorrhizae, 100 parts of ligusticum wallichii and 100 parts of puerarin as main raw materials. The preparation method comprises the following steps: respectively extracting the salviae miltiorrhizae, ligusticum wallichii and puerarin, respectively purifying through macroporous resin columns, and uniformly mixing. Compared with compositions prepared by other methods by using the same raw materials, the composition disclosed by the invention has better curative effects.

Description

technical field [0001] The invention relates to a composition for treating ischemic cardiovascular and cerebrovascular diseases, arteriosclerosis, cerebral thrombosis, cerebral ischemia, coronary heart disease and angina pectoris and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Tongmai Recipe is a traditional Chinese medicine compound. For ischemic cardiovascular and cerebrovascular diseases, arteriosclerosis, cerebral thrombosis, cerebral ischemia, coronary heart disease, angina pectoris, etc. The Tongmai recipes currently in the market mainly include Tongmai Oral Liquid, Tongmai Injection, Tongmai, Tongmai Granules and Tongmai Capsules. to make. Among them, Tongmai, Tongmai granules and Tongmai oral liquid are all traditional Chinese medicine preparations according to the pharmaceutical standard of the Ministry of Health. [0003] The currently listed Tongmai granules are in accordance with the drug standard W...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/16A61P9/10A61P7/02
CPCA61K9/1623A61K36/236A61K36/488A61K36/537A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2236/55A61K2300/00
Inventor 李志刚张纲胡向青郝福李东王娇孙胜斌关秀伟
Owner SHINEWAY PHARMA GRP LTD