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A continuous acidification process for 4,6-dihydroxypyrimidine

A technology of dihydroxypyrimidine and sodium hydroxypyrimidine, which is applied in the field of 4,6-dihydroxypyrimidine continuous acidification process, can solve the problems of harming workers' health, long acidification time, increasing workers' labor intensity, etc., so as to achieve physical health and surrounding environment. The effect of guaranteeing and reducing the occurrence of side reactions and shortening the contact time of materials

Active Publication Date: 2019-03-19
石家庄杰克化工有限公司
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Problems solved by technology

[0002] The existing acidification process of 4,6-dihydroxypyrimidine is intermittent acidification, the single-pot acidification needs to be discharged and then re-acidified, the acidification time is long, the output is small, the acidification kettle is used, and the quality is unstable; moreover, the acidification process requires many In this way, in the process of manual sampling, not only the labor intensity of workers will be increased, but also acidic smell will emerge, which will pollute the environment and endanger the health of workers. In order to improve the working environment and stabilize the production quality, it is necessary to develop a Continuous Acidification Process

Method used

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  • A continuous acidification process for 4,6-dihydroxypyrimidine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1, such as figure 1 Shown, in this invention, the specific steps of 4,6-dihydroxypyrimidine continuous acidification process are as follows:

[0019] A, inorganic acid aqueous solution is hydrochloric acid aqueous solution, sulfuric acid aqueous solution or phosphoric acid aqueous solution, preferred hydrochloric acid aqueous solution, organic acid aqueous solution is formic acid aqueous solution, acetic acid aqueous solution, benzenesulfonic acid aqueous solution or chloroacetic acid aqueous solution, preferred chloroacetic acid aqueous solution, the concentration is 15% hydrochloric acid The aqueous solution passes through the liquid feed pump according to the flow rate of 0.5T / h and the aqueous solution of 4,6-dihydroxypyrimidine sodium with a concentration of 20% according to the flow rate of 0.5T / h. Mix with a static mixer, and output the mixed liquid through the first static mixer after mixing evenly, the outlet temperature of the first static mixer is 40°...

Embodiment 2

[0023] Embodiment 2, the specific steps of 4,6-dihydroxypyrimidine continuous acidification process are as follows:

[0024] A. Pass the sulfuric acid aqueous solution with a concentration of 10% according to the flow rate of 1T / h and the aqueous solution of 4,6-dihydroxypyrimidine sodium with a concentration of 10% according to the flow rate of 2.41T / h respectively through the liquid feed pump, through the corresponding intelligent The flow meter accurately adjusts the flow rate and enters the first static mixer for mixing. After mixing evenly, the mixed liquid is output through the first static mixer. The outlet temperature of the first static mixer is 30°C;

[0025] B. Input the mixed liquid into the first-stage tubular reactor, control the reaction temperature at 40°C with circulating water, and stop the reaction for 30s to generate a primary reaction liquid, then take a sample and perform a pH test, if the pH value is 2-6 In between, the first-stage reaction liquid is dir...

Embodiment 3

[0028] Embodiment 3, the specific steps of 4,6-dihydroxypyrimidine continuous acidification process are as follows:

[0029] A. Pass the sulfuric acid aqueous solution with a concentration of 12% according to the flow rate of 2T / h and the aqueous solution of 4,6-dihydroxypyrimidine sodium with a concentration of 15% according to the flow rate of 5.75T / h respectively through the liquid feed pump, through the corresponding intelligent The flow meter accurately adjusts the flow rate and enters the first static mixer for mixing. After mixing evenly, the mixed liquid is output through the first static mixer. The outlet temperature of the first static mixer is 30°C;

[0030] B. Input the mixed liquid into the first-stage tubular reactor, control the reaction temperature at 30°C with circulating water, and stop the reaction for 30 seconds to generate a first-level reaction liquid, then take a sample and test the pH value, the pH value is 5.5, which meets the standard range, do not ad...

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Abstract

The invention relates to a continuous acidification process for 4,6-dyhydroxy pyrimidine and belongs to the technical field of chemical synthesis. The continuous acidification process includes the steps that an inorganic acid water solution or an organic acid water solution and a 4,6-dyhydroxy pyrimidine water solution are input in a first static mixer section to be mixed, then mixed liquor is input in a first tubular reactor section for reacting to obtain primary reaction liquid, the pH value is detected, if the pH value is not within the standard range, acid or alkali needs to be supplemented for adjustment, then the reaction liquid is sequentially input in a second static mixer section and a second tubular reactor section, and secondary reaction liquid is obtained; then the secondary reaction liquid is input in a thickener for layering, slurry on the lower layer is input in a centrifuge for solid-liquid separation, obtained solids are dried, and then finished 4,6-dyhydroxy pyrimidine is obtained. The process achieves continuous production, is convenient to operate, has fewer side reactions, short reaction time, stable quality and high yield, is relatively safer and more environmentally friendly, has good economic and social value, and has wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a 4,6-dihydroxypyrimidine continuous acidification process. Background technique [0002] The existing acidification process of 4,6-dihydroxypyrimidine is intermittent acidification, the single-pot acidification needs to be discharged and then re-acidified, the acidification time is long, the output is small, the acidification kettle is used, and the quality is unstable; moreover, the acidification process requires many In this way, in the process of manual sampling, not only the labor intensity of workers will be increased, but also acidic smell will emerge, which will pollute the environment and endanger the health of workers. In order to improve the working environment and stabilize the production quality, it is necessary to develop a Continuous acidification process. Contents of the invention [0003] In order to overcome the problems existing in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D239/54
CPCC07D239/54
Inventor 张辰亮李红路李玉顺郭会刘少华程丽华彭艳丽
Owner 石家庄杰克化工有限公司