Nicotinic acid injection for treating heart diseases and preparation method thereof

A technology for injection and heart disease, which is applied in the field of injection, can solve the problems of unsatisfactory effect of anemia and heart disease, unsatisfactory treatment effect of traditional Chinese medicine preparations, and unremarkable clinical experiment effect, and achieve animal experiments and good clinical effect. Strong practicability and significance, the effect of strong chemical stability of the drug

Inactive Publication Date: 2017-02-08
广州市桐晖药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, western medicines are mainly used in the treatment of anemia and heart disease, but western medicines have large toxic and side effects, single curative effect, and low cure rate; The impact is still relatively large, and most of them have certain side effects, which partially limit their clinical application and make the control of heart disease unsatisfactory.
[0004] The traditional Chinese medicine treatment of heart disease particularly emphasizes the overall concept, coordination of yin and yang, and multi-link conditioning. Vigorously develop and promote the use...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The nicotinic acid injection for treating heart disease is composed of the following components by weight percentage: 1.0% of safflower pure essential oil, 1.0% of nicotinic acid, 200.8% of Span, 2% of traditional Chinese medicine extract, 0.6% of atropine sulfate, and the remaining water for injection quantity.

[0020] The traditional Chinese medicine extract is obtained by extracting 10 parts by weight of Danshen, 4 parts of Pueraria lobata, 8 parts of lotus leaves and 16 parts of Inula inulae through alcohol extraction.

[0021] The preparation steps of the above-mentioned nicotinic acid injection are as follows:

[0022] (1) Wash the salvia miltiorrhiza, kudzu root, lotus leaf and inula inulae, dry them in the air, crush them to 80 mesh, add them into ethanol with a volume fraction of 70%, and extract them under reflux at 70°C for 3 hours, collect the extracted distillate, and cool After reaching room temperature, filter, concentrate and recover ethanol, dialyze w...

Embodiment 2

[0025] The niacin injection for treating heart disease is composed of the following components by weight percentage: Houttuynia cordata pure essential oil 1.3%, niacin 0.8%, Span 600.6%, traditional Chinese medicine extract 2.5%, atropine sulfate 0.7%, water for injection margin.

[0026] The traditional Chinese medicine extract is obtained by extracting 12 parts by weight of Danshen, 3 parts of Pueraria root, 10 parts of lotus leaf and 14 parts of Inula inulae through alcohol extraction.

[0027] The preparation steps of the above-mentioned nicotinic acid injection are as follows:

[0028] (1) Wash the salvia miltiorrhiza, kudzu root, lotus leaf and inula inulae, dry them in the air, crush them to 90 mesh, add them into ethanol with a volume fraction of 65%, reflux and extract at 75°C for 2.5h, collect the extracted distillate, After cooling to room temperature, filter, concentrate and recover ethanol, dialyze with a dialysis membrane with a molecular weight cut-off of 2000-...

Embodiment 3

[0031] The niacin injection for treating heart disease consists of the following components by weight percentage: ginseng pure essential oil 1.6%, niacin 0.6%, Span 85 0.8%, traditional Chinese medicine extract 2%, atropine sulfate 0.8%, water for injection quantity.

[0032] The traditional Chinese medicine extract is obtained by extracting 14 parts by weight of Danshen, 2 parts of Pueraria lobata, 12 parts of lotus leaves and 12 parts of Inula inulae through alcohol extraction.

[0033] The preparation steps of the above-mentioned nicotinic acid injection are as follows:

[0034] (1) Wash the salvia miltiorrhiza, kudzu root, lotus leaf and inula inulae, dry them in the air, crush them to 100 mesh, add them into ethanol with a volume fraction of 60%, reflux extraction at 80°C for 2 hours, collect the extracted distillate, and cool After reaching room temperature, filter, concentrate and recover ethanol, dialyze with a dialysis membrane with a molecular weight cut-off of 2000...

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PUM

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Abstract

The invention discloses a nicotinic acid injection for treating heart diseases and a preparation method thereof. The nicotinic acid injection for treating heart diseases is prepared from pure essential oil, nicotinic acid, Span, a traditional Chinese medicine extracting solution, atropine sulfate and water for injection. The preparation method comprises the following steps: carrying out alcohol reflux extraction on radix salviae miltiorrhizae, kudzu root, lotus leaf and Inula, carrying out filter concentration and dialyzing to obtain the traditional Chinese medicine extracting solution; and proportionally mixing the traditional Chinese medicine extracting solution with the essential oil, nicotinic acid, Span and atropine sulfate, carrying out high-pressure steam sterilization, cooling and carrying out vacuum packaging. The nicotinic acid injection can be used for intravenous injection, has the advantages of high pharmacochemical stability, low toxicity and high drug specificity, has favorable curative effects on treating anemic cardiopathy, and has excellent animal experiment and clinical effects. The nicotinic acid injection is simple to prepare and low in cost, and has high practicality and important meanings for people with anemic cardiopathy.

Description

technical field [0001] The invention relates to the field of injections, in particular to a niacin injection for treating heart disease and a preparation method thereof. Background technique [0002] Heart disease is a common and frequently-occurring disease worldwide, and it is also one of the main causes of death from cardiovascular and cerebrovascular diseases in humans. With the improvement of living conditions, the incidence of such diseases is getting higher and higher. Among them, the incidence of anemia and heart disease accounted for a large part of the probability. [0003] At present, western medicines are mainly used in the treatment of anemia and heart disease, but western medicines have large toxic and side effects, single curative effect, and low cure rate; The impact is still relatively large, and most of them have certain side effects, which partially limit its clinical application and make the control of heart disease unsatisfactory. [0004] The traditio...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K36/62A61K9/08A61P9/00A61K31/455A61K31/46
CPCA61K36/537A61K9/0019A61K9/08A61K31/455A61K31/46A61K36/258A61K36/28A61K36/286A61K36/287A61K36/488A61K36/62A61K36/78A61K2236/333A61K2236/55
Inventor 张彤丽石炜
Owner 广州市桐晖药业有限公司
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