Method for measuring content of TSNAs (tobacco-specific nitrosamines) in mainstream smoke of cigarettes
A technology for mainstream cigarette smoke and mainstream smoke, which is applied to the detection of harmful components in cigarette smoke and the determination of the content of TSNAs in mainstream cigarette smoke, can solve the problems of complex processing process, poor selectivity, difficulty in measurement, etc. Effects of increased extraction efficiency, ease of operation, increased selectivity and sensitivity
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[0036] Further description will be made below in conjunction with specific examples.
[0037] The instruments and reagents used in this example are: Waters Xevo TQ ultra-high performance liquid chromatography-tandem mass spectrometer (Waters, USA), equipped with an electrospray ionization source (ESI); VtexMixer 230VeU oscillator (Labnet, USA).
[0038] Formic acid is HPLC grade (concentration is 49-51%, German Sigma company); Acetonitrile, methanol are chromatographically pure (U.S. Thermo-Fisher company); TSNAs, TSNAs-d 4 (Purity: 98%; Isotopic purity: 99%, Toronto Research Chemicals Inc.), water is ultrapure water.
[0039] The present invention uses ammonium acetate aqueous solution as the extraction liquid, vortex oscillation extraction, matrix dispersion extraction and purification, deuterated internal standard quantification, UPLC-MS / MS measurement and other steps to measure TSNAs in mainstream smoke, which can be quickly, accurately and simultaneously detected The con...
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