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Lesion signature to characterize pathology for specific subject

An object, lesion technology, applied in the field of tissue characterization, which can solve the problems of reducing the reliable identification of tissue characterization, large variability, etc.

Active Publication Date: 2017-03-01
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to date these methods have gained limited acceptance because of the typically large variability in characterizing parameter values ​​across populations, and because of the significant overlap seen between normal and pathological tissues
These all reduce the ability of tissue characterization to reliably identify pathology without presenting unacceptable levels of false positives

Method used

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  • Lesion signature to characterize pathology for specific subject
  • Lesion signature to characterize pathology for specific subject
  • Lesion signature to characterize pathology for specific subject

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Embodiment Construction

[0012] According to the principles of the present invention, an improved method and system are provided to identify the same type of lesions in a subject, and thereby better determine the true scope of the disease, especially when using imaging modalities with limited accuracy or sensitivity ( Such as ultrasound). One method described in this article uses certain concepts of image-based tissue characterization, but overcomes many of the limitations of existing methods by using the patient as their own "control", thus significantly reducing the variability of image-based characterization parameters, and Improve the possibility of using imaging methods with other limited accuracy and sensitivity to identify pathological tissues. This can be done by obtaining a clear confirmation of the pathology of a specific suspicious lesion, for example based on a biopsy, etc., but also based on the first imaging modality with higher diagnostic accuracy, and then extracting the second (less ac...

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Abstract

A system for identifying tissue includes a subject-specific tissue signature (48) derived from an ultrasound image. The tissue signature has specified ranges of characteristics based on analysis of a reference tissue of a subject having a confirmed pathology. A searching module (140) is stored in memory and is configured to search through images (134) for a volume of the subject to identify tissues in the images for comparison. A comparison module (124) configured to identify tissue matches between the tissue signature of the reference tissue and the tissue signature of the tissues in the volume in accordance with a score based upon the specified ranges of characteristics.

Description

Technical field [0001] The present disclosure relates to tissue characterization, and more specifically to systems and methods for determining and adopting subject-specific tissue signatures to characterize similar tissues in a subject. Background technique [0002] Tissue characterization is typically used to try to identify or detect diseased tissue in a target population, for example as an aid to screening. There are many medical conditions, including primary or secondary cancers, in which patients may present more than one pathological lesion of the same type or origin. Unfortunately, in many cases, some of these lesions are recessive. In other words, the lesion is not recognized by one or more imaging modalities, and can remain undetected for a period of time. One example is liver cancer, where, according to some reports, up to 30% of patients may have additional cancerous lesions that are not recognized until the start of liver surgery, even though patients have been imag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/08G06F19/00G06T7/00A61B8/00
CPCA61B8/085A61B8/5223G06T7/0012A61B8/5207A61B8/483A61B8/5261A61B8/4245G06T2207/30024G16H30/40G16H50/20A61B8/461G06T2207/10132G06T2207/30096
Inventor J·R·杰戈T·P·J·A·戈捷G·C-H·吴
Owner KONINKLJIJKE PHILIPS NV