Domestic pig ISG15 recombination protein and encoding gene, recombination plasmid, recombination strain and application thereof

A technology of recombinant protein and recombinant plasmid, which is applied in the field of genetic engineering to achieve the effects of controlling acute infection, reducing the amount of antigen, and controlling viral infection
CN106496320AInactive Publication Date: 2017-03-15HENAN AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HENAN AGRICULTURAL UNIVERSITY
Publication Date
2017-03-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of gene engineering, and particularly discloses a domestic pig ISG15 recombination protein and an encoding gene, a recombination plasmid, a recombination strain and application thereof. An amino acid sequence of the domestic pig ISG15 reconstruction protein is shown in SEQ ID No.2. A gene of the domestic pig ISG15 recombination protein, and the recombination plasmid and the recombination strain containing the gene are encoded. One of the domestic pig ISG15 recombination protein, the gene, the recombination plasmid and the recombination strain is applied to prepare a medicine for treating PR (pseudorabies). The domestic pig ISG15 recombination protein has the advantages that the antigen amount of the PRV (pseudorabies virus) is effectively reduced, the acute infection of the PRV is effectively controlled, and a new path is provided for controlling the virus infection.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a domestic pig ISG15 recombinant protein and its coding gene, recombinant plasmid, recombinant bacterial strain and application. Background technique

[0002] ISG15 is an interferon-stimulated gene 15 (isg15), and its encoded protein is ISG15 protein. The stimulation of virus or type I interferon can induce the high expression of ISG15 protein, and its molecular mass is about 17ku. ISG15 has the functions of cytokine activity, regulating interferon signaling pathway, anti-virus and anti-bacterial infection, etc., and plays an important role in innate immunity. ISG15 protein has certain differences among different organisms. At present, the reports on ISG15 mainly focus on human and mouse, and they are all researches on anti-virus and other aspects. At present, there is no report on the function of this protein in domestic pigs.

[0003] Porcine pseudor...

Claims

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