Preparation method of liquid antibacterial protective films

A liquid and solution technology, applied in medical science, bandages, etc., can solve the problems of poor use and treatment effect, poor broad-spectrum antibacterial performance, and short duration of effect, so as to promote wound healing, reduce antigen content, increase relative capacitive effect

Inactive Publication Date: 2017-11-03
常州市天宁区鑫发织造有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after use, the broad-spectrum antibacterial property becomes worse, and the duration of effect is short, resulting in poor use and treatment effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] Preparation of filling solution: mix distilled water, glycyrrhetinic acid, glucuronic acid and geniposide evenly according to the mass ratio of 6:2:2:1.

[0024] Preparation of supernatant:

[0025] (1) According to the mass ratio of 1:7-10, take silkworm cocoon shells and 5% sodium bicarbonate solution by mass fraction and put them into a container, set the temperature at 90-95°C, keep it warm for 45-55min, then cool naturally to room temperature, and filtering the mixture in the container, collecting the filtered matter, putting the filtered matter into an air dryer to air dry, collecting the air-dried matter, and obtaining the pretreated cocoon shell;

[0026] (2) Add the filling liquid from the mouth of the pretreated cocoon shell to the above pretreated cocoon shell, the amount of filling liquid added to each pretreated cocoon shell is 0.8 to 1.2 times the mass of each pretreated cocoon shell, and the addition is completed Finally, put the filled pretreated cocoon...

example 1

[0032] Preparation of supernatant:

[0033] (1) According to the mass ratio of 1:7, take silkworm cocoon shells and 5% sodium bicarbonate solution and put them into a container, set the temperature at 90°C, keep it warm for 45 minutes, cool it to room temperature naturally, and carry out the mixture in the container Filtrate, collect the filtrate, put the filtrate into an air dryer to air dry, collect the air-dried matter, and obtain the pretreated silkworm cocoon shell;

[0034] (2) Add the filling liquid from the mouth of the pretreated cocoon shell to the above-mentioned pretreated cocoon shell. The amount of filling liquid added to each pretreated cocoon shell is 0.8 times the mass of each pretreated cocoon shell. After the addition is completed, Put the filled pretreated silkworm cocoon shells at 45°C overnight, put them into a press, and squeeze them at 20MPa for 3 minutes. Put into the pulverizer and pulverize, the pulverized matter is passed through a 200-mesh sieve, ...

example 2

[0039] Preparation of decolorizing solution: according to the mass ratio of 1:1:2:4, take carrageenan, coptis, Phellodendron cortex and distilled water and put them into a cooking tank, set the temperature at 102°C, and the pressure at 0.8MPa. After cooking for 4 hours, cool naturally to At room temperature, filter the cooking mixture, collect the filtrate, mix the filtrate with activated carbon with 10% mass of the filtrate for decolorization for 20 minutes, and then filter to collect the decolorized solution.

[0040] The antibacterial properties of the decolorizing solution in the liquid antibacterial wound protection film obtained in this example were tested, and the results are shown in Table 1.

[0041] Table I:

[0042] bacteria

[0043] Standby: the antibacterial rate in the table above is the antibacterial rate of Staphylococcus aureus, Escherichia coli, Candida albicans and Pseudomonas aeruginosa after the decolorizing solution in the liquid antibacterial w...

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PUM

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Abstract

The invention belongs to the field of medical materials and particularly relates to a preparation method of liquid antibacterial protective films. The preparation method includes: after subjecting cocoon shells to degreasing and adhesive materials removing through a sodium bicarbonate solution, adding filling fluid to the cocoon shells for standing overnight, and obtaining sieving particles via extruding, drying, smashing and sieving; performing mixed enzymolysis with distilled water and the like under the alkaline condition to obtain a digested mixture; adjusting the digested mixture to neutral with hydrochloric acid prior to performing centrifugal separation to obtain a supernate; performing mixed cooking with carrageenan, distilled water and the like prior to mixed decolorizing with activated carbon after filtration to obtain a destaining solution after filtration; subjecting the destaining solution to mixed concentration with the supernate to obtain the liquid antibacterial protective films. The method is simple in process, the obtained protective films are good in biocompatibility, good broad-spectrum antibacterial property in use is achieved, efficiency time can be effectively prolonged, and good use and therapeutic effects are achieved.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a preparation method of a liquid antibacterial wound protection film. Background technique [0002] With the growth of social economy, the advancement of industrialization, and the rapid development of transportation, the number of chronic wounds caused by various traumas is increasing. In addition, as the aging society intensifies, the number of chronic wounds caused by diabetes and vascular diseases is increasing rapidly. Chronic refractory wounds have many causes and complex mechanisms. The primary measures of general trauma treatment are to clean and disinfect the wound surface, and protect the wound surface with wound dressings to prevent subsequent infection. In recent years, with the continuous development of wound dressings, various wound protection films have been launched. However, most wound protection films are made of synthetic materials, such as silicon...

Claims

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Application Information

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IPC IPC(8): A61L26/00
Inventor 赵玲玲盛开洋宋昊
Owner 常州市天宁区鑫发织造有限公司
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