A method for determining the yield of o-aminophenol by using o-nitrophenol by high-performance liquid chromatography
A high-performance liquid chromatography and o-aminophenol technology, which is applied in the direction of analyzing materials, measuring devices, and material separation, can solve problems that have not yet been discovered, and achieve the effect of accurate yield
Inactive Publication Date: 2019-04-16
TAIYUAN UNIV OF TECH
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For example, "Chemical Bulletin", 2012, (9): "Simultaneous determination of 11 aminophenols in hair dyes by high performance liquid chromatography" reported on P870-875; "Chemical Bulletin", 2011, (12): P 1140-1144 "Microwave Assisted-Headspace Liquid Microextraction HPLC Analysis of O-Nitrophenol in Water Samples" reported above, etc., have not yet found an analytical method that can simultaneously determine these two compounds
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[0017] The present invention will be further described below in conjunction with embodiment:
[0018] Instruments and reagents used in this embodiment
[0019] Shimadzu Corporation LC-10A high performance liquid chromatograph equipped with SHIMADZU SPD-10Avp detector, N-2000 chromatographic data workstation, CTO-10ASvp column oven, SCL-10Avp system controller; SK250HP ultrasonic cleaner (Shanghai Branch guide ultrasonic instrument); BS-1105 precision electronic balance (Beijing Sartorius); FB-01T solvent filter (Tianjin Hengao).
[0020] Methanol is chromatographically pure (Tianjin Siyou), standard o-nitrophenol (99%) and o-aminophenol (98%) (Sarn Chemical Technology (Shanghai)), water is ultrapure water, and all reagents are Filtered through a 0.22 um filter and degassed by ultrasound.
[0021] Obtaining o-nitrophenol by high-performance liquid chromatography analysis method takes peak area as the standard curve figure of ordinate concentration as abscissa, obtains o-amino...
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The invention relates to a yield determining method, in particular to a method using high performance liquid chromatography to determine the yield of o-aminophenol prepared by using o-nitrophenol. The method includes: standard curves, using peak area as vertical coordinates and concentration as horizontal coordinates, of o-nitrophenol and o-aminophenol are acquired respectively through the high performance liquid chromatography; the high performance liquid chromatogram of the final sample solution of the o-aminophenol prepared by using the o-nitrophenol is obtained by the high performance liquid chromatography; the peak area of the o-nitrophenol and the o-aminophenol are acquired respectively from the high performance liquid chromatogram and substituted into the standard curves obtained in the first step to acquire the concentration of the o-nitrophenol and the o-aminophenol respectively.
Description
technical field [0001] The invention relates to a method for determining yield, in particular to a method for determining the yield of o-aminophenol by using o-nitrophenol through high-performance liquid chromatography analysis. Background technique [0002] O-aminophenol is an important chemical intermediate widely used in dyes, medicine, printing and biology. It can be used in the preparation of sulfur dyes, azo dyes and fluorescent whitening agents, as well as plastic curing agents and pharmaceutical products. In recent years, it has been found that o-aminophenol can be used as a chemical modification reagent for fatty acids for the analysis of fatty acids. The Schiff base made of o-aminophenol and carbonyl compounds and some metal complexes thereof have important functions in catalytic behavior, magnetic properties and enzyme simulation. also plays an important role. [0003] The preparation of o-aminophenol is mainly obtained by reducing o-nitrophenol, and the methods...
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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 李彦威王丽丽邢俊德刘强张朝峰常宏宏李兴魏文珑
Owner TAIYUAN UNIV OF TECH