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A nanosupramolecular assembly of fully methylated β-cyclodextrin-modified nanographene/porphyrin

A technology of supramolecular assembly and nano-graphene, which is applied in the direction of non-effective components of polymer compounds, inorganic non-effective components, recombinant DNA technology, etc., can solve the problem that nano-graphene porphyrin is rare and limits the application of hexabenzocoronene derivatives and other problems, to achieve the effect of strong cutting ability, good DNA cutting performance, and broad application prospects

Inactive Publication Date: 2019-03-19
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Since hexabenzocoronex derivatives are generally only soluble in organic solvents (such as dichloromethane, chloroform, toluene, etc.), the relevant application reports are mostly limited to nanoelectronic devices, which limits the use of hexabenzocoronex derivatives in other researches. field application
Especially in the field of biomedicine, such as: photothermal, photodynamic therapy, etc., reports on nano-graphene porphyrin are rare

Method used

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  • A nanosupramolecular assembly of fully methylated β-cyclodextrin-modified nanographene/porphyrin
  • A nanosupramolecular assembly of fully methylated β-cyclodextrin-modified nanographene/porphyrin
  • A nanosupramolecular assembly of fully methylated β-cyclodextrin-modified nanographene/porphyrin

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Embodiment

[0026] A nano-supramolecular assembly of nano-graphene / porphyrin modified by fully methylated β-cyclodextrin, the chemical formula of its building block is: C 252 h 375 N 9 o 114 and C 44 h 26 N 4 Na 4 o 12 S 4 , the chemical structural formula is as follows:

[0027]

[0028] The supramolecular assembly is constructed through the interaction between fully methylated β-cyclodextrin and sodium porphyrin tetrasulfonate, and its morphology scale is a nanoscale, network-like aggregate; the preparation method steps are as follows:

[0029] 1) Dissolve 200 mg of three propynyl-modified hexabenzocorones and 1.12 g of 6-deoxy-6-azido-permethylated-β-cyclodextrin in 100 mL of N,N-dimethyl For formamide, add 146 mg of cuprous iodide, then heat up to 120°C under nitrogen protection for 72 hours, filter, spin dry, and perform column chromatography with a mixed solution of dichloromethane and methanol at a volume ratio of 40:1 , to obtain yellow fully methylated β-cyclodeposit...

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Abstract

The invention provides a permethylated beta-cyclodextrin modified nano graphene / porphyrin nano-supramolecular assembly. The chemical formula of a building unit of the assembly is C252H375N9O114 and C44H26N4Na4O12S4, and a chemical structural formula is as follows: shown in the description. The supramolecular assembly is built through high non-covalent interaction of permethylated beta-cyclodextrin modified nano graphene and tetra(sodium sulfonate) porphyrin, has nanoscale morphology size, and is netlike aggregate. The permethylated beta-cyclodextrin modified nano graphene / tetra(sodium sulfonate) porphyrin has the advantages of simple and convenient preparation method and good water solubility; under the light condition, the supramolecular assembly shows good cutting performance for DNA (deoxyribonucleic acid), and has wide application prospect in the field of photodynamics therapy.

Description

technical field [0001] The invention belongs to the technical field of nano-supramolecular materials, in particular to a supramolecular assembly of fully methylated β-cyclodextrin-modified nano-graphene / porphyrin. Background technique [0002] In recent years, nano-graphene with definite structure artificially synthesized by "bottom-up" strategy has received more and more attention due to its special properties and possible practical applications, see: (1) M.Ball, Y.Zhong , Y. Wu, C. Schenck, F. Ng, M. Steigerwald, S. Xiao and C. Nuckolls, Acc. Chem. Res., 2015, 48, 267-276. (2) M. Kastler, J. Schmidt, W . Pisula, D. Sebastiani and K. Müllen, J. Am. Chem. Soc., 2006, 128, 9526-9534. However, among many nano-graphenes, hexabenzocoronene derivatives, also known as the nano-graphene with the smallest structure, are the hotspots of research. Utilizing the π-π stacking properties of hexabenzocoronene derivatives, unique electron transfer characteristics and easy self-assembly a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/40
CPCA61K41/0071A61K47/02A61K47/40C08B37/0012C12N15/10
Inventor 刘育喻杰张瀛溟王丽华
Owner NANKAI UNIV