Antineoplastic medicine prepared through gelsmium elegans medicinal materials
An anti-tumor drug and anti-tumor technology, applied in the field of anti-tumor drugs, can solve the problems of the clinical application constraints of the original medicinal materials and crude extracts of Gelkins
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[0031] Such as figure 1 As shown, the preparation method of the anti-tumor drug prepared by using the medicinal material of gecko according to the embodiment of the present invention comprises the following steps:
[0032] S101: Take fresh or dried decoction pieces of vine stems, roots and leaves, and add ethanol (50-95% ethanol concentration, preferably 70%) in an amount 6 to 12 times the mass of fresh or dry decoction pieces of vine stems, roots and leaves, or Methanol, acetone, ethyl acetate and other organic solvents, soaked and extracted, the extract was filtered while it was hot, and the organic solvents such as ethanol were recovered under reduced pressure with a vacuum rotary evaporator, extracted 1 to 3 times, the filtrates were combined, concentrated until no alcohol smell, added Dissolve a certain amount of acid solution such as hydrochloric acid or sulfuric acid and adjust the pH to acidity 1-5. Do this for 3-6 times until the alkaloid test of the supernatant is ne...
Embodiment 1
[0040] (1) Take the fresh or dried decoction pieces of the Glycyrrhizae vine, add ethanol (50% to 95% ethanol concentration, preferably 70%) or methanol in an amount 6 to 12 times the mass of the fresh or dry decoction pieces of the Glycyrrhizae vine, soak and extract, and the extract Suction filtration while it is hot, recover ethanol and other organic solvents under reduced pressure with a vacuum rotary evaporator, extract 1 to 3 times, combine the filtrates, concentrate until there is no alcohol smell, add a certain amount of hydrochloric acid to dissolve and adjust the pH to acidity 1 to 5, This operation was performed 3 to 6 times until the alkaloid test of the supernatant was negative or weakly positive, and the supernatant was combined.
[0041] (2) Add sodium hydroxide to adjust the pH to 8-13 alkaline, and extract the alkalized solution with 2-6 times the amount of chloroform for 3-6 times until the liquid alkaloid test after alkalization is negative or weakly positive...
Embodiment 2
[0046] (1) Take fresh or dried fresh or dried decoction pieces of Glycyrrhiza foliage, add ethanol (50% to 95% ethanol concentration, preferably 70%) or acetone in an amount 6 to 12 times the mass of fresh or dry decoction pieces of Glycyrrhiza foliage, soak and extract, The extract is filtered while it is hot, and organic solvents such as ethanol are recovered under reduced pressure with a vacuum rotary evaporator, extracted for 1 to 3 times, the filtrate is combined, concentrated until there is no alcohol smell, dissolved in an acid solution with a certain amount of sulfuric acid, and the pH is adjusted to an acidic value of 1-3. 5. Do this for 3 to 6 times until the alkaloid test of the supernatant is negative or weakly positive, and then combine the supernatant.
[0047] (2) Add potassium hydroxide to adjust the pH to 8-13 alkaline, and use 2-6 times the amount of dichloromethane petroleum ether organic solvent to extract the alkalized solution for 3-6 times until the alkal...
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