Processing method for prepared kusnezoff monkshood roots

A technology for producing Fructus Fructus and Fructus Fructus, which is applied in the field of processing Fructus Fructus Fructus, can solve the problems of insatiability, difficulty in ensuring the stability of raw materials in different batches, poor product quality stability, etc., and achieve the effect of accurate soaking time.

Inactive Publication Date: 2017-03-29
辽宁光太药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] There is an obvious defect in these methods in the prior art, that is, there is no effective monitoring means in the processing process, so it is impossible to make scientific adjustments to the processing process according to the raw material situation (due to the alkaloid content and variety of Aconitum radix, growth The environment, etc. are closely related an

Method used

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  • Processing method for prepared kusnezoff monkshood roots
  • Processing method for prepared kusnezoff monkshood roots
  • Processing method for prepared kusnezoff monkshood roots

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 15kg of Aconitum medicinal material, wash it with water, add 150L of water to soak, change the water every 12 hours, take the soaking solution on the 1st, 2nd, 3rd, 4th, 5th, and 6th day respectively, and measure aconitine and neoaconitine , the total weight content of hypoaconitine, the specific values ​​are shown in Table 1. After soaking for 6 days, the total content of the three alkaloids in the soaking liquid is 18.7mg / L. At this time, stop soaking, take it out and cook in a cooking tank (98±2°C), change the water every hour, and add 150L of water each time. After boiling for 3 hours, take it out, let it dry in the air, cut into thin slices (thickness 1-2mm), and dry at 74°C for 4 hours.

[0033] The product is determined according to the method under the item of "Chinese Pharmacopoeia" (2010 edition one): the total weight content of the diester type alkaloids (aconitine, neoaconitine, hypoaconitine), and the monoester type alkaloids The total weight content ...

Embodiment 2

[0035] Take 15kg of Aconitum aconitum medicinal material, wash it with water, add 120L of water to soak, change the water every 12 hours, take the soaking solution on the 1st, 2nd, 3rd, 4th, 5th, 6th, and 7th day to measure the aconitine and new aconitine The total weight content of alkali and hypoaconitine, the specific values ​​are shown in Table 1. After soaking for 7 days, the total content of the three alkaloids in the soaking liquid is 10.7mg / L. At this time, stop soaking, take it out and cook in a cooking tank (96±2°C), change the water every hour, and add 120L of water each time. After cooking for 3 hours, take it out, let it dry in the air, cut into thin slices (thickness 1-2mm), and dry at 70°C for 4 hours.

[0036] The product is determined according to the method under the item of "Chinese Pharmacopoeia" (2010 edition one): the total weight content of the diester type alkaloids (aconitine, neoaconitine, hypoaconitine), and the monoester type alkaloids The total we...

Embodiment 3

[0038] Take 15kg of Aconitum medicinal material, wash it with water, add 90L of water to soak, change the water every 12 hours, take the soaking solution on the 1st, 2nd, 3rd, and 4th day to measure aconitine, neoaconitine, and hypoaconitine The total weight content, the specific values ​​are shown in Table 1. After soaking for 4 days, the total content of the three alkaloids in the soaking liquid is 14.1mg / L. At this time, stop soaking, take it out and cook in a cooking tank (92±2°C), change the water every hour, and add 90L of water each time. After boiling for 3 hours, take it out, let it dry in the air, cut into thin slices (thickness 1-2 mm), and dry at 65°C for 5 hours.

[0039]The product is determined according to the method under the item of "Chinese Pharmacopoeia" (2010 edition one): the total weight content of the diester type alkaloids (aconitine, neoaconitine, hypoaconitine), the monoester type alkaloids The total weight content of alkali (benzoyl aconitine, benz...

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Abstract

The invention relates to the field of prepared kusnezoff monkshood roots which are traditional Chinese medicine decoction pieces, in particular to a processing method for prepared kusnezoff monkshood root medicinal materials. The method includes the following steps that a, unprocessed kusnezoff monkshood root medicinal materials are obtained, cleaned with water and then soaked in water, the mass ratio of the medicinal materials to the water is 1:(6-10), and the water is replaced once every 12 hours; b, HPLC detection is carried out on soaking liquid, according to a detection result, soaking can be finished when the total concentration of aconitine, mesaconitine and hypaconitine in the soaking liquid is 10-20 mg/L, the medicinal materials are taken out, placed in a cooking pot and boiled in the way of adding water, the mass ratio of the medicinal materials to the water is 1:(6-10), and clear water is replaced once every an hour; and c, the medicinal materials are boiled for 2-4 hours, then taken out, dried in the air, sliced, and dried for 4-6 h at the temperature of 65-75 DEG C, and processed kusnezoff monkshood root products, namely the prepared kusnezoff monkshood roots can be obtained. By the adoption of the method provided by the invention, kusnezoff monkshood root medicinal materials different in quality can be processed effectively, prepared kusnezoff monkshood root products meeting the national pharmacopeia standard are obtained, and economic benefits of enterprises are increased while vast patients are benefited.

Description

technical field [0001] The invention relates to the field of preparing Aconitum aconitum from decoction pieces of traditional Chinese medicine, in particular to a processing method for preparing Aconitum aconitum medicinal material. Background technique [0002] Aconitum aconitum is the dry tuber root of Aconitum aconitum, a plant of the family Ranunculaceae. It originated from "Shen Nong's Materia Medica", also known as Aconitum aconitum, aliases: five poisonous roots, Aconitum aconitum, heartbroken grass, duck head, Artemisia annua, chicken head grass , Centipeda. Grass Aconitum was known to our ancestors as early as 2000 years ago. It has the functions of expelling wind and dampness, warming meridians and relieving pain. Aconitine is highly toxic, and the main toxic components are diester alkaloids such as aconitine, neoaconitine and hypoaconitine. Adults will produce poisoning reaction after oral administration of 0.2mg, 2~4mg·kg -1 Can cause death. Therefore, the med...

Claims

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Application Information

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IPC IPC(8): A61K36/714
CPCA61K36/714A61K2236/13A61K2236/15A61K2236/17
Inventor 王雁铭
Owner 辽宁光太药业有限公司
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