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Western medicine composition for treating spinal cord injury, and application of composition

A spinal cord injury and composition technology, which is applied in the field of western medicine composition for the treatment of spinal cord injury, can solve the problems of timeliness in the use of adverse drug reactions, and achieve good long-term effects, long-lasting therapeutic effects, and accelerated recovery of motor function

Inactive Publication Date: 2017-04-26
ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, drugs represented by methylprednisolone (methylprednisolone, referred to as methylprednisolone) have achieved certain curative effects in clinical application, but the adverse reactions of drugs and the timeliness of use make people continue to seek effective drugs. medicine

Method used

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  • Western medicine composition for treating spinal cord injury, and application of composition
  • Western medicine composition for treating spinal cord injury, and application of composition
  • Western medicine composition for treating spinal cord injury, and application of composition

Examples

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Effect test

Embodiment 1

[0016] In an embodiment of the present invention, a western medicine composition for treating spinal cord injury is composed of hysonaline and sulbactam; wherein, the mass ratio of hysonaline and sulbactam is 0.17:1.

Embodiment 2

[0018] In an embodiment of the present invention, a western medicine composition for treating spinal cord injury is composed of hysonaline and sulbactam; wherein, the mass ratio of hysonaline and sulbactam is 0.22:1.

Embodiment 3

[0020] In an embodiment of the present invention, a western medicine composition for treating spinal cord injury is composed of hysonaline and sulbactam; wherein, the mass ratio of hysonaline and sulbactam is 0.18:1.

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Abstract

The invention discloses a western medicine composition for treating spinal cord injury, and an application of the composition. The western medicine composition consists of hexoprenaline and sulbactam, wherein a mass ratio of hexoprenaline to sulbactam is (0.17-0.22) : 1; and when the western medicine composition is used for treating the spinal cord injury, an injection dose for adults is 0.95-1.00mg / kg, and the administration time is 6-24 hours after the spinal cord injury. Through test treatment of a model of an animal with spinal cord injury, it is discovered that the western medicine composition can reduce cell apoptosis, facilitate neuronal survival, inhibit glial scar formation and remarkably improve a BBB score of the treated animal, so that the western medicine composition has a remarkable promotion effect for motor function recovery after the spinal cord injury. Compared with an existing common medicine-methylprednisolone used for treating the spinal cord injury in clinic, the western medicine composition has the advantages that an administration window is wider, the treatment effect is more lasting, and the long-term effect is better.

Description

technical field [0001] The invention relates to the technical field of western medicine, in particular to a western medicine composition for treating spinal cord injury and its application. Background technique [0002] With the development of the economic level of countries in the world, the incidence of spinal cord injury is increasing year by year. Spinal cord injury refers to the spinal cord injury caused by external direct or indirect factors, and various motor, sensory and sphincter dysfunctions, abnormal muscle tone and corresponding changes in pathological reflexes appear in the corresponding segments of the damage. Spinal cord injury is the most serious complication of spinal cord injury, often leading to severe dysfunction of the limbs below the level of injury. Spinal cord injury will not only bring serious physical and psychological harm to the patients themselves, but also cause a huge economic burden to the whole society. Due to the social and economic losses...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61P25/00A61K31/137
CPCA61K31/43A61K31/137A61K2300/00
Inventor 不公告发明人
Owner ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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