A kind of Zn-Fe series zinc alloy and its preparation method and application

A technology of zinc alloy and zn-fe, which is applied in the field of medical metal material preparation, achieves the effect of excellent blood compatibility and good degradation speed

Active Publication Date: 2019-05-14
湖南华翔医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no literature and patents at home and abroad to report the preparation and properties of Zn-Fe alloys, and it is proposed to use Zn-Fe alloys as biodegradable biomedical materials

Method used

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  • A kind of Zn-Fe series zinc alloy and its preparation method and application
  • A kind of Zn-Fe series zinc alloy and its preparation method and application
  • A kind of Zn-Fe series zinc alloy and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Embodiment 1, preparation Zn-Fe series zinc alloy:

[0109] 1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), pure Fe powder (purity 99.9+%, particle size <10 μm) (purchased from Alfa Aesar) as raw materials, according to different quality Ratio (mass ratio of Zn to Fe is 99:1, 98:2, 95:5, 90:10) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and mixed by a planetary ball mill. The ball milling speed is 200rpm, the ball-to-material ratio is 20:1, and the ball milling time is 60 minutes to obtain a uniform mixture of different Zn and Fe mass ratios, which are stored in an argon protective atmosphere to prevent oxidation;

[0110] 2) Put the homogeneous mixture in step 1) into the graphite abrasive tool, pressurize axially and sinter by spark plasma vacuum: the initial sintering pressure is 1MPa, the heat preservation sintering pressure is 50MPa, firstly the temperature is raised to 250℃ at ...

Embodiment 2

[0111] Embodiment 2, preparation Zn-Fe series zinc alloy:

[0112] 1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), pure Fe powder (purity 99.9+%, particle size <10 μm) (purchased from Alfa Aesar) as raw materials, according to different quality Ratio (mass ratio of Zn to Fe is 99:1, 98:2, 95:5, 90:10) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and mixed by a planetary ball mill. The ball milling speed is 200rpm, the ball-to-material ratio is 20:1, and the ball milling time is 60 minutes to obtain a uniform mixture of different Zn and Fe mass ratios, which are stored in an argon protective atmosphere to prevent oxidation;

[0113] 2) in CO 2 and SF 6 Under the protection of the atmosphere, the homogeneous mixture in step 1) is mixed and sintered by element powder: the homogeneous mixture is pressed into a billet, and then in the vacuum sintering furnace, the temperature is slowly raised to...

Embodiment 3

[0115] Embodiment 3, preparation Zn-Fe series zinc alloy:

[0116] 1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), pure Fe powder (purity 99.9+%, particle size <10 μm) (purchased from Alfa Aesar) as raw materials, according to different quality Ratio (mass ratio of Zn to Fe is 99:1, 98:2, 95:5, 90:10) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and mixed by a planetary ball mill. The ball milling speed is 200rpm, the ball-to-material ratio is 20:1, and the ball milling time is 60 minutes to obtain a uniform mixture of different Zn and Fe mass ratios, which are stored in an argon protective atmosphere to prevent oxidation;

[0117] 2) in CO 2 and SF 6 Under the protection of the atmosphere, the homogeneous mixture in step 1) is melted at 800° C., and then cooled to obtain the Zn—Fe-based zinc alloy.

[0118] 3) hot rolling and finishing rolling are carried out successively to the Zn-Fe ser...

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Abstract

The invention discloses a Zn-Fe system zinc alloy and a preparation method and application thereof. The zinc alloy comprises Zn and Fe. The mass percentage of Fe in the zinc alloy is 0-10%, exclusive of 0. The zinc alloy further comprises a trace element, which is at least one of silicon, phosphorus, lithium, silver, tin and a rare earth element and has the mass percentage being 0-3%, exclusive of 0. The mechanical property of the Zn-Fe system zinc alloy conforms to the strength and toughness requirements of a medical implant material, is free of toxicity to endothelial cells and osteoblast, and can inhibit proliferation of smooth muscle cells. The Zn-Fe system zinc alloy is excellent in histocompatibility and blood compatibility and can be degraded by the body fluid through regulation and control. The dissolution metal ions can be absorbed and utilized through the living body or be excreted out of the body through metabolism. The zinc alloy is excellent in antibacterial performance and can be applied to preparation of a medical implant.

Description

technical field [0001] The invention belongs to the technical field of medical metal material preparation, and relates to a Zn-Fe zinc alloy and its preparation method and application, in particular to a Zn-Fe zinc alloy, its preparation method and its use in the preparation of body fluid degradable medical implants. in the application. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace diseased tissues and organs of living organisms or enhance their functions. It is the basis for the study of artificial organs and medical devices, and can be divided into repair materials, cardiovascular system materials, medical membrane materials, drug release carrier materials, biosensor materials, dental materials, etc. according to their uses. According to the composition and properties, there are mainly biomedical metal materials, bioceramics, biomedical polymers, biomedical composite materials and bio-derived materials. Biomed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/58A61L27/50A61L31/02A61L31/14A61L17/06A61K6/04C22C18/00
Inventor 郑玉峰杨宏韬成艳
Owner 湖南华翔医疗科技有限公司
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