Biomedical controllable degradable CaZn base amorphous alloy

An amorphous alloy, biomedical technology, applied in the biomedical field, can solve the problems of limiting the direct use of Ca and its conventional alloys, and achieve the effects of ensuring mechanical stability, high elastic strain, and low magnetic susceptibility

Active Publication Date: 2014-05-07
INST OF PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unfortunately, however, its high activity limits the direct use of Ca and its conventional alloys in complex environments in vivo

Method used

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  • Biomedical controllable degradable CaZn base amorphous alloy
  • Biomedical controllable degradable CaZn base amorphous alloy
  • Biomedical controllable degradable CaZn base amorphous alloy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: CaZn-based amorphous alloy Ca 60 Zn 15 Mg 20 Sr 5 preparation of

[0037] After the Ca and Sr raw materials with a purity of not less than 99wt% and the four components of Zn and Mg with a purity of not less than 99.9wt% are prepared in a molar ratio of 60:15:20:5, the raw materials are placed in a quartz tube and placed in a high frequency induction furnace. Use a vacuum pump to evacuate to 5.0×10 -4 Above Pa, after filling with an appropriate amount of high-purity argon, heat it with a high-frequency coil and small current until it melts. Stir evenly with electromagnetic, and spray-cast it into a copper mold cooled with liquid nitrogen, that is, the composition is Ca 60 Zn 15 Mg 20 Sr 5 , A bulk amorphous alloy with a diameter of 5 mm; if sprayed on a rotating copper wheel, amorphous strips can be obtained, and powder can be obtained after ball milling. The material has good biocompatibility and mechanical properties, and can b...

Embodiment 2

[0041] Embodiment 2: CaZn-based amorphous alloy Ca 35 Zn 20 Mg 25 Sr 20 preparation of

[0042] After the Ca and Sr raw materials with a purity of not less than 99wt% and the four components of Zn and Mg with a purity of not less than 99.9wt% are prepared in a molar ratio of 35:20:25:20, the raw materials are placed in a quartz tube and placed in a high frequency induction furnace. Use a vacuum pump to evacuate to 5.0×10 -4 Above Pa, after filling with an appropriate amount of high-purity argon, heat it with a high-frequency coil and small current until it melts. Stir evenly with electromagnetic, and spray-cast it into a copper mold cooled with liquid nitrogen, that is, the composition is Ca 35 Zn 20 Mg 25 Sr 20 , A bulk amorphous alloy with a diameter of 2mm; if sprayed on a rotating copper wheel, amorphous strips can be obtained, and powder can be obtained after ball milling. The material has good biocompatibility and mechanical properties, and can...

Embodiment 3

[0046] Embodiment 3: CaZn-based amorphous alloy Ca 32 Zn 34 Mg 16 Sr 18 preparation of

[0047] After the Ca and Sr raw materials with a purity of not less than 99wt% and the four components of Zn and Mg with a purity of not less than 99.9wt% are prepared in a molar ratio of 32:34:16:18, the raw materials are placed in a quartz tube and placed in a high frequency induction furnace. Use a vacuum pump to evacuate to 5.0×10 -4 Above Pa, after filling with an appropriate amount of high-purity argon, heat it with a high-frequency coil and small current until it melts. Stir evenly with electromagnetic, and spray-cast it into a copper mold cooled with liquid nitrogen, that is, the composition is Ca 32 Zn 34 Mg 16 Sr 18 A bulk amorphous alloy; if sprayed on a rotating copper wheel, amorphous strips can be obtained, and powder can be obtained after ball milling. The material has good biocompatibility and mechanical properties, and can be degraded and absorbed...

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Abstract

The invention relates to a biomedical degradable alloy, specifically to a CaZn base amorphous alloy, in which Ca and Zn are used as main components, an appropriate amount of micro alloying elements are added and at least an amorphous phase of 50% (volume percentage) is contained. The mechanical property, corrosion rate and biocompatibility of the alloy are regulated by changing the atomic percent of Ca and Zn and adding micro alloying elements in order to satisfy different demands of implanted tissue. The alloy can be used to prepare temporary or short-term implantable devices, such as vascular stents, bone tissue substitution or repairing materials as well as scaffold materials of tissue engineering.

Description

technical field [0001] The present invention relates to a biomedical degradable alloy, in particular to a CaZn-based amorphous alloy (also known as "metallic glass") with CaZn as the main component and comprising at least 50% of the amorphous phase (volume percentage). " or " metal plastic ") and application thereof, belong to the biomedical field. Background technique [0002] Degradable biomedical materials can avoid the inconvenience and danger caused by long-term implantation of medical devices, and reduce the economic losses and personal injuries caused by secondary operations, which is one of the important directions for the development of biomedical materials. The shortcomings of the polymer and ceramic materials that have been researched and developed at present have stimulated the biomedical attempts of metallic materials due to their shortcomings in mechanical properties. In the past ten years, magnesium alloys have made a series of important progress in the field...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C45/00A61L27/04
Inventor 焦维赵昆赵德乾汪卫华
Owner INST OF PHYSICS - CHINESE ACAD OF SCI
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