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A kind of zn-mg1ca series zinc alloy and its preparation method and application

A technology of zinc alloys and mixtures, used in pharmaceutical formulations, dental preparations, compression mold cups, etc., to achieve the effects of excellent blood compatibility and good degradation speed

Active Publication Date: 2019-07-09
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no documents and patents at home and abroad to report the preparation and properties of Zn-Mg1Ca series zinc alloy and its application in biodegradable biomedical materials

Method used

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  • A kind of zn-mg1ca series zinc alloy and its preparation method and application
  • A kind of zn-mg1ca series zinc alloy and its preparation method and application
  • A kind of zn-mg1ca series zinc alloy and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Embodiment 1, preparation Zn-Mg1Ca series zinc alloy:

[0112] 1) Pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), Mg1Ca alloy powder (containing 0.98wt.% Ca, particle size 74-150 μm) (purchased from Tangshan Weihao Magnesium Powder Co., Ltd. ) as raw materials, according to different mass ratios (mass ratios of Zn to Mg1Ca are 99:1, 98:2, 95:5 respectively) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and passed through a planetary ball mill Ball milling and mixing, ball milling speed 200rpm, ball to material ratio 20:1, ball milling time 60min, to obtain a uniform mixture of different mass ratios of Zn and Mg1Ca, and store it in an argon protective atmosphere to prevent oxidation;

[0113] 2) Put the homogeneous mixture in step 1) into the graphite abrasive tool, pressurize axially and sinter by spark plasma vacuum: the initial sintering pressure is 1MPa, the heat preservation sintering pressu...

Embodiment 2

[0114] Embodiment 2, preparation Zn-Mg1Ca series zinc alloy:

[0115] 1) Pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), Mg1Ca alloy powder (containing 0.98wt.% Ca, particle size 74-150 μm) (purchased from Tangshan Weihao Magnesium Powder Co., Ltd. ) as raw materials, according to different mass ratios (mass ratios of Zn to Mg1Ca are 99:1, 98:2, 95:5 respectively) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and passed through a planetary ball mill Ball milling and mixing, ball milling speed 200rpm, ball to material ratio 20:1, ball milling time 60min, to obtain a uniform mixture of different mass ratios of Zn and Mg1Ca, and store it in an argon protective atmosphere to prevent oxidation;

[0116] 2) in CO 2 and SF 6 Under the protection of the atmosphere, the homogeneous mixture in step 1) is subjected to high-energy ball milling, then press-molded, and heat-treated at 350° C. for 15 hours to obtai...

Embodiment 3

[0118] Embodiment 3, preparation Zn-Mg1Ca series zinc alloy:

[0119] 1) Pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), Mg1Ca alloy powder (containing 0.98wt.% Ca, particle size 74-150 μm) (purchased from Tangshan Weihao Magnesium Powder Co., Ltd. ) as raw materials, according to different mass ratios (mass ratios of Zn to Mg1Ca are 99:1, 98:2, 95:5 respectively) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and passed through a planetary ball mill Ball milling and mixing, ball milling speed 200rpm, ball to material ratio 20:1, ball milling time 60min, to obtain a uniform mixture of different mass ratios of Zn and Mg1Ca, and store it in an argon protective atmosphere to prevent oxidation;

[0120] 2) in CO 2 and SF 6Under the protection of the atmosphere, the homogeneous mixture in step 1) is melted at 800 ° C, and then cooled to obtain the Zn-Mg1Ca-based zinc alloy;

[0121] 3) Extruding the Zn-Mg...

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Abstract

The invention discloses a Zn-Mg1Ca series zinc alloy and preparing method and application of Zn-Mg1Ca series zinc alloy. The zinc alloy comprises Zn and Mg1Ca, wherein the mass percent of Mg1Ca in the zinc alloy ranges from 0 to 10% but not includes 0. The zinc alloy further comrpsies a microelements which are at least one of silicon, phosphorus, lithium, silver, tin and rare earth elements. The mass percent of the microelements ranges from 0 to 3% but not includes 0. The mechanical property of the Zn-Mg1Ca series zinc alloy meets the requirement for strength and toughness of medical implant materials, the Zn-Mg1Ca series zinc alloy is free of cytotoxicity on endothelial cells and bone-forming cells, can inhibit smooth muscle cell proliferation and has good tissue compatibility and blood compatibility, meanwhile, the Zn-Mg1Ca series zinc alloy can also be regulated to be degraded by body liquid, metal ions which are dissolved out can be absorbed and utilized by an organism or metabolized to be discharged out of the body, and the Zn-Mg1Ca series zinc alloy has good antibacterial performance and can be applied to preparation of medical implants.

Description

technical field [0001] The invention belongs to the technical field of medical metal material preparation, and relates to a Zn-Mg1Ca series zinc alloy and its preparation method and application, in particular to a Zn-Mg1Ca series zinc alloy and its preparation method and its use in the preparation of body fluid degradable medical implants in the application. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace diseased tissues and organs of living organisms or enhance their functions. It is the basis for the study of artificial organs and medical devices, and can be divided into repair materials, cardiovascular system materials, medical membrane materials, drug release carrier materials, biosensor materials, dental materials, etc. according to their uses. According to the composition and properties, there are mainly biomedical metal materials, bioceramics, biomedical polymers, biomedical composite materials and bio-deri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/02A61L27/04A61L27/54A61K6/04C22C18/00C22C1/04
CPCA61K6/84A61L27/047A61L27/54A61L31/022A61L31/16A61L2300/102A61L2300/404C22C1/0483C22C18/00
Inventor 郑玉峰杨宏韬成艳
Owner PEKING UNIV
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