A kind of zn-hap series zinc alloy and its preparation method and application

A technology of zinc alloy and mixture, which is applied in pharmaceutical formulations, dental preparations, molded cups, etc., to achieve the effects of good degradation speed, excellent blood compatibility, and controllable blood compatibility

Active Publication Date: 2018-05-18
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, Lepu (Beijing) Medical Devices Co., Ltd. has a patent on degradable new base alloy stents, and Xi'an Advance Medical Technology Co., Ltd. has a patent on the preparation method of medical biodegradable zinc alloy capillary tubes and corrosion-resistant high-strength zinc alloys. Patents for alloy implant materials, there are no literature and patents at home and abroad to report the preparation and performance of Zn-HAP zinc alloys, and it is proposed to use Zn-HAP zinc alloys as biodegradable biomedical materials

Method used

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  • A kind of zn-hap series zinc alloy and its preparation method and application
  • A kind of zn-hap series zinc alloy and its preparation method and application
  • A kind of zn-hap series zinc alloy and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0082] Embodiment 1, preparation Zn-HAP series zinc alloy:

[0083] 1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), HAP powder (purity 99%, length 150nm) (purchased from Beijing Deke Island Gold Co., Ltd.) as raw materials, according to different Mass ratio (mass ratio of Zn to HAP is 99:1, 95:5, 90:10 respectively) in a vacuum glove box, put into a vacuum ball mill tank under the protection of argon, and mix evenly through a planetary ball mill at a ball milling speed of 250rpm , the ball-to-material ratio is 10:1, and the ball milling time is 40 minutes to obtain a uniform mixture of different Zn and HAP mass ratios, which are stored in an argon protective atmosphere to prevent oxidation;

[0084] 2) Put the homogeneous mixture in step 1) into the graphite abrasive tool, pressurize axially and sinter by spark plasma vacuum: the initial sintering pressure is 1MPa, the heat preservation sintering pressure is 60MPa, firstly the tempe...

Embodiment 2

[0085] Embodiment 2, preparation is coated with the Zn-HAP series zinc alloy of ceramic coating:

[0086] 1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), HAP powder (purity 99%, length 150nm) (purchased from Beijing Deke Island Gold Co., Ltd.) as raw materials, according to different Mass ratio (mass ratio of Zn to HAP is 99:1, 95:5, 90:10 respectively) in a vacuum glove box, added to a vacuum ball mill jar under the protection of argon, and mixed by a planetary ball mill at a ball milling speed of 200rpm , the ball-to-material ratio is 20:1, and the ball milling time is 60 minutes to obtain a uniform mixture of different Zn and HAP mass ratios, which are stored in an argon protective atmosphere to prevent oxidation;

[0087] 2) Put the homogeneous mixture in step 1) into the graphite abrasive tool, pressurize axially and sinter by spark plasma vacuum: the initial sintering pressure is 1MPa, the heat preservation sintering pressure ...

Embodiment 3

[0090] Embodiment 3, Zn-HAP zinc alloy microstructure analysis

[0091] The Zn-HAP zinc alloy in Example 1 was prepared by wire-cutting a 10×10×1mm sample, which was sequentially ground and polished by 400#, 800#, 1200# and 2000# SiC sandpaper series. After ultrasonic cleaning in acetone, absolute ethanol and deionized water for 15 min, dry at 25 °C. The sample was subjected to X-ray diffraction analysis, etched with 4% nitric acid alcohol for 5-30 seconds, washed with deionized water, dried, observed under a metallographic microscope, and tested for density by a densitometer.

[0092] figure 1 It is Zn-HAP series zinc alloy metallographic, from figure 1 It can be seen that HAP is evenly distributed on the boundary of pure Zn particles. With the increase of HAP content, HAP on the boundary begins to gather, which breaks the bond between pure Zn particles. The main physical link between pure Zn particles and HAP The binding did not take place chemically.

[0093] figure 2...

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Abstract

The invention discloses Zn-HA series zinc alloy, and a preparation method and application thereof. The zinc alloy provided by the invention comprises Zn and HA, wherein the mass percentage of the HA in the zinc alloy is 0 to 10 percent, but does not include 0. The zinc alloy also comprises trace elements, wherein the trace elements are at least one of silicon, phosphorus, lithium, silver, tin and rare earth element; and the mass percentage of the trace elements is 0 to 3 percent, but does not include 0. The Zn-HA series zinc alloy provided by the invention has the mechanical properties according with the requirements of a medical implant material on strength and toughness, does not have cytotoxicity on endothelial cells and osteoblasts, can inhibit proliferation of smooth muscle cells and has good histocompatibility and blood compatibility; meanwhile, the Zn-HA series zinc alloy can be regulated, controlled and degraded by body fluid and the dissolved metal ions can be absorbed and utilized by a living body or can be metabolized and discharged out of the body; and the Zn-HA series zinc alloy also has excellent antibacterial property and can be applied to preparation of medical implants.

Description

technical field [0001] The invention belongs to the technical field of medical metal material preparation, and relates to a Zn-HAP series zinc alloy and its preparation method and application, in particular to a Zn-HAP series zinc alloy and its preparation method and its use in the preparation of body fluid degradable medical implants in the application. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace diseased tissues and organs of living organisms or enhance their functions. It is the basis for the study of artificial organs and medical devices, and can be divided into repair materials, cardiovascular system materials, medical membrane materials, drug release carrier materials, biosensor materials, dental materials, etc. according to their uses. According to the composition and properties, there are mainly biomedical metal materials, bioceramics, biomedical polymers, biomedical composite materials and bio-derived ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C18/00C22C1/04A61L31/02A61L31/16A61K6/04A61K6/033A61L27/12A61L27/04A61L27/54A61K6/838
CPCA61K6/838A61K6/84A61L27/047A61L27/12A61L27/54A61L31/022A61L31/16A61L2300/412A61L2430/02B22F3/105B22F3/14C22C1/0483C22C18/00
Inventor 郑玉峰杨宏韬成艳
Owner PEKING UNIV
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