Licochalcone A thiouracil derivatives with antitumor activity and synthesis method thereof

The technology of a licorice chalcone and a synthetic method, which is applied in the field of medicinal chemistry, can solve problems such as poor water solubility, and achieve the effects of low production cost, mild reaction conditions, and environmentally friendly raw materials

CN106674128AInactive Publication Date: 2017-05-17SHAANXI UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2017-05-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses licochalcone A thiouracil derivatives with antitumor activity and a synthesis method thereof. The licochalcone A thiouracil derivatives, compounds, are synthesized from licochalcone A and thiourea compounds by reacting with methylbenzene as a solvent. The synthesis method has the advantages of high safety and mild reaction conditions and is applicable to industrialized production. Preliminary biological activity tests show that the compounds are high in antitumor activity and can be used for studying antitumor lead compounds.
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