38 results about "Thiouracil" patented technology

The invention discloses 6-cyclohexyl methyl substituted S-DABO type compound, the synthesis method and the application, belonging to the medical technical field. The invention relates to a 5-alkyl-6-cyclohexyl methyl-2-(alkyl, naphthenic base, naphthenic base methyl, substituted phenylethanone) thiouracil type compound, which has general formula as shown in (I): wherein, R1 is alkyl of C1-3; alkyl, naphthenic base and naphthenic base methyl of R2=C1-8 are as shown in (II); wherein, X=OCH3, H, OH, halogen. Chloromethyl cyclohexane or cyclohexyl acetic acid is respectively used as raw material to prepare Beta- keto ester which is made into a key intermediate 5-alkyl-6-cyclohexyl methyl thiouracil together with thiourea through close loop condensation under the catalyzing of sodium alkoxide; target molecule is prepared through S-alkylation guiding C2-side chain. The invention has the advantages of simple and easy synthesis method, obvious anti-HIV virus activity and anti-resistance for the drugs and ability to be used as an alternative for anti-HIV drug.

The invention discloses a modified zirconium-based organic metal framework adsorbent for adsorbing lead ions as well as a preparation method and application of the modified zirconium-based organic metal framework adsorbent. The method comprises the following steps: reacting 2-aminoterephthalic acid, zirconium tetrachloride and hydrochloric acid in N, N-dimethylformamide to obtain a product UiO-66-NH<2>, then reacting the product UiO-66-NH<2> with glutaraldehyde to obtain a product UiO-66-GD, and reacting UiO-66-GD with 6-amino-2-thiouracil to obtain the modified zirconium-based organic metal framework adsorbent UiO-66-ATA. The method is simple to operate, the preparation method is simple, raw materials and reagents are cheap and easy to obtain, the obtained metal organic framework can be compatible with various functional groups, has ultrahigh specific surface area and permanent porosity, has high selectivity and high flux adsorption effect on lead ions, a novel efficient adsorption material is provided for lead-containing sewage treatment, and a new method is provided for design and synthesis of the novel adsorption material.

The invention discloses a preparation method of uracil. The method comprises the following steps: (a) enabling ethyl formate, ethyl acetate and sodium methylate to react so as to prepare sodium (E)-3-ethoxy-3-oxoprop-1-en-1-olate; (b) adding thiourea and ethyl acetate into the sodium (E)-3-ethoxy-3-oxoprop-1-en-1-olate, heating for carrying out a reaction, and acidizing by using hydrochloric acid to obtain thiouracil; (c) adding alkali and ethanol into the thiouracil, cooling and then dropwise adding a hydrogen peroxide water solution into the cooled mixture; after that, heating for carrying out a reaction to obtain the uracil. According to the technology for preparing the uracil by using the thiourea as a raw material, the used raw materials such as ethyl formate, the ethyl acetate, the thiourea and hydrogen peroxide are chemical products which are common, easy to obtain and low in price, so that the production cost is lower. The preparation method of the uracil is simple, convenient and fast to operate and high in yield, thus being suitable for large-scale industrial production.

S-DABO composition and its synthesis method and function belong to medicine technical medicine. The invention relates to a 5-alkyl-6-phenyl-2-(substituted arylcarbonylmethylsulfur)uracil composition, having following general formula: wherein, R1 is C1-3 alkyl; R2=C1-6 alkyl, substituted furan ring, thiofuran ring, benzene ring (substituent on the benzene ring is H, OH, Cl3 alkoxy), having the 5-alkyl-6-phenylthiouracil as reagent, reacting with alpha-halogen ketone to get the inventive product which is catalyzed by K2CO3. The synthesis method is easy to operate. The product has an obvious anti-HIV virus activity, a low toxicity, a high selectivity index and can be an anti-HIV medicine candidate.

The invention discloses a preparation method for lightproof and waterproof polyurethane coating. The preparation method for the lightproof and waterproof polyurethane coating comprises the following steps: under the condition that the dibutyltin dilaurate catalyst exists, PTMG and dicyclohexyl methane diisocyanate are mixed; the reaction is conducted for 1-4 hours at a temperature of 60-85 DEC G; methyl thiouracil and drostanolone are added; the reaction time lasts for 1 hour; the reaction temperature is 80 DEC G; a polyurethane prepolymer A is obtained; chain extender, N- methyl pyrrolidone and formamide are added to the polyurethane prepolymer A; the reaction is conducted for 2.5-3.5 hours at 75 -85 DEC G; a mixed liquor A is added; the reaction temperature is 70-95 DEC G; the reaction time is 2-3 hours; a neutralizers is added for a neutralization reaction for 30-50 min; water is added for emulsification; the lightproof and waterproof polyurethane coating is obtained. The prepared lightproof and waterproof polyurethane coating is environment friendly and inexpensive in price. Therefore, the lightproof and water-based polyurethane coating can be extensively applied to surfaces of the wall bodies, furniture and metal wares and served as binding agent of plastics, glass, paper manufacturing and textile.

The invention provides an L-histidine high-yielding strain and an application thereof, and belongs to the field of a bioengineering technology. The invention provides Serratia marcescens ZJZG25 which is obtained by the following steps of: by taking Serratia marcescens ATCC (American Type Culture Collection) 31026 as a starting strain, carrying out diethyl sulfate (DES), nitrosoguanidine (NTG) and ultraviolet (UV) gradual-grade mutation; and adding analogues of L-histidine including 3-amino-1,2,4-triazole, 6-purinethol, histidine methyl ester, 2-thiouracil, D-histidine and the like into a basic culture medium and screening. The L-histidine is produced by a strain fermentation method; and compared with the starting strain, the capability of the accumulating high-level L-histidine is expressed. The ZJZ 625 is subjected to shake-flask culture for 72 hours and the yield of the L-histidine can reach to 9.7 g / L. The fermentation is a 3-L fermentation tank is carried out for 60 hours and the yield of the L-histidine can reach to 18.1 g / L.

The invention discloses a quality control material for metabolomics detection and a quality control method of the quality control material. The quality control material comprises mixed standard samples of 4,4'-methylene bis(2-chloroaniline), p-anisidine, L-tyrosine methyl ester, 3-chloroaniline, 2,4-dimethyl quinoline, sulfapyridine, atrazine, sulfadoxine, DL-leucine, N-benzoyl-L-tyrosine ethyl ester, 6-phenyl-2-thiouracil, N-(o-toluoyl) glycine, 2-methyl-5-nitroimidazole-1-ethanol, glycyrrhetinic acid, flavanone, Epsilon-caprolactone and 2-aminopyridine. 17 standard samples in the method comefrom different material categories and are very stable, simple in preparation and small in amount; and the quality control material disclosed by the invention can accurately reflect the state of a chromatograph or a mass spectrometer.

Compounds represented by the formula (I) R is H, OH, alkyl, O-alkyl, CH2—O-alkyl, (CH2)nOH, (CH2)nNH2, (CH2)nCONH2, (CH2)nOOOH; R1 is H, OH, alkyl, O-alkyl, CH2—O-alkyl, C6H11, CH2OH; R2 is H, alkyl, OH, CH2OH, CH2—O-alkyl, CH(OH)-alkyl, CH(OH)CH2OH, CH2-halogen; R3 and R4 independently is H, OH, alkyl; Z is OR5, OR6, or aminoacids and esters thereof R5 and R6 independently is H, alkyl, aryl, pivaloyloxymethyl, C(R7)2OC(O) X (R8)a formula (II), R7 independently is —H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or —OR9; R9 is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl or C5-C12 aryl; provided that at least one R8 is not H; and a is 1 when X is CH2, or direct bond, or 1 or 2 when X is N with the proviso that when a is 2 and X is N, (a) two N-linked R groups can be taken together to form a carbocyclic or oxygen containing heterocycle, (b) one N-linked R8 additionally can be —OR9 or (c) both N-linked R8 groups can be —H; R10 is H or C1-C8 alkyl; R11 is selected from H, alkyl, alkenyl, alkynyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl n is 1-5 m is 0 to 5 X is S, N(R8) or direct bond Y is O, S, N (R8), and CHR1 B is selected from the group consisting of adenine, guanine, cytosine, uracil, thymine, modified purines and pyrimidines such as inosin-9-yl, 2-amino-purin-9-yl, 2amino-6-chloro-purin-9-yl, 2-6-diamino-purin-9-yl, 3-carboxamido-1, 2, 4-triazol-1-yl, 3-deaza-adenin-9-yl, 3-deaza-guanin-9-yl, 3-deaza-inosin-9-yl, 3-deaza-2-amino-purin-9-yl, 3-deaza-2-amino-6-chloro-purin-9-yl, 3-deaza-2, 6-diamino-purin-9-yl, 7-deaza-adenin-9-yl, 7-deaza-guanin-9-yl, 7-deaza-inosin-9-yl, 7-deaza-2-amino-purin-9-yl, 7-deaza-2-amino-6-chloro-purin-9-yl, 7-deaza-2-6-diamino-purin-9-yl, 7-deaza-8-aza-adenin-9-yl, 7-deaza-8-aza-guanin-9-yl, 7-deaza-8-aza-inosnin-9-yl, 7-deaza-8-aza-2-amino-purin-9-yl, 7-deaza-8-aza-2-amino-6-chloro-purin-9-yl, 7-deaza-8-aza-2-6-diamino-purin-9-yl, -8-aza-adenin-9-yl,-8-aza-guanin-9-yl, -8-aza-inosnin-9-yl, -8-aza-2-amino-purin-9-yl, -8-aza-2-amino-6-chloro-purin-9-yl, -8-aza-2-6-diamino-purin-9-yl, 5-aza-thymin-1-yl, 5-aza-cytosin-1-yl, 5-aza-uracil-1-yl, 6-aza-thymin-1-yl, 6-aza-cytosin-1-yl, 6-aza-uracil-1-yl, 2-thiouracil-1-yl, 4-thiouracil-1-yl, 2 thiocytosine-1-yl, uracil-5-yl, 2-thiouracil-5-yl, 4-thiouracil-5-yl, substituted pyridine derivatives such as 6-azauracil, and azacyzosine. In general, attachment may be at different positions in the ring at nitrogen or carbon. These B ring systems may be substituted with halo, alkyl, substituted alkyl (F, Cl, Br, I, OH), NH2, N3, aryl, substituted aryl (F, Cl, Br, I, OH, NH2), aralkyl; and pharmaceutically acceptable salts thereof and prodrugs thereof are provided.

The invention relates to a mono-propargylamine modified thiouracil compound, and applications thereof. The structure of the mono-propargylamine modified thiouracil compound is novel; the mono-propargylamine modified thiouracil compound possesses cholinesterase inhibition activity, monoamine oxidase activity, and metal ion chelating properties, is capable of inhibiting generation of metal ion-induced free radicals, and inhibiting metal ion-induced Abeta aggregation, is low in cytotoxicity, and is high in blood brain barrier penetration rate in vitro experiment. Preparation technology is simple; preparation cost is low; and it is promising to prepare multifunctional drugs used for treating, improving and / or preventing Alzheimer disease from the mono-propargylamine modified thiouracil compound.

The S-DABO compound, its synthesis method and application belong to the technical field of medicine. The invention relates to a 5-alkyl-6-phenyl-2-(substituted arylcarbonylmethylthio)uracil compound, which has the following general formula: wherein: R1 is a C1-3 alkyl group; R2=C1-6 alkyl, substituted furan ring, thiophene ring, benzene ring (substituents on the aromatic ring are H, OH, C1-3 alkoxy). The product of the present invention is obtained by reacting 5-alkyl-6-phenylthiouracil with a-halogenated ketone under K2CO3 catalysis. The synthesis method is simple and easy, and the product has significant anti-HIV virus activity, low toxicity and high selectivity index, and can be used as a candidate anti-HIV drug.

The invention is composed of 0.5%-30% thiouracil or thiouracil complex, 0.1%-10% zinc source and 30%-80% organic amine. The percentage above is based on weight of concentrate of combination.

This invention relates to S-DABO type reverse transcriptiveenzyme inhibitor-2-(substituted aryl alkyl or alkoxy carbonyl methyl sulfur)-5-alkyl-6-(1-naphthyl methyl) uracil compound, and its prepn. method, its application of anti-HIV virus, with its formula, where: R1=H, C1-5 alkyl; R2=C1-6 alkyl; C1-6 alkoxy, arylcyclo-R3, aryl heterocycle-R3, C3-6 cycloalkyl-R3, arylcyclo, aryl heterocycle, C3-6 cycloalkyl substituting group R3 being H, 1-3 same or different; C1-3 alkyl, halogen, group R3 being H, 1-3 same or different: C1-3 alkyl, halogen, C1-3 ether group, OH. In this invention, 5-alkyl-6-(1-naphthylmethyl) thiourea uracil is used as reactor reacting with alpha-halogenated ketone or alpha-halogenated acetate, in the presence of catalyst of K2CO3. Said invention products can eliminate HIV-1 virus, HIV-2 SOD virus and HIV-1 (III B) SO561945.

The invention discloses an ultra-thin copper foil and a preparation method thereof, belonging to the technical field of ultra-thin copper foil preparation. The present invention uses cyclohexyl hexaphosphoric acid and 2-thiouracil as an organic layer to adsorb on a metal foil carrier, then deposits a tungsten-nickel alloy containing rare earth elements Pr and Nd on the organic layer, and then deposits copper three times To prepare ultra-thin copper foil, the copper deposition electrolyte of the present invention contains a composite additive of sodium lignosulfonate and chitosan oligosaccharide, and the copper deposition electrolyte realizes ultra-thin copper foil under the action of rare earth elements Pr and Nd in the alloy layer. Lightweight uniform deposition enables ultra-thin copper foil to break through the limit of 4μm to achieve ultra-light weight of 3.5μm, and the tensile performance is as high as 510MPa, and the elongation rate can reach up to 10%, endowing lightweight ultra-thin copper foil with excellent performance.

The invention discloses an electroplating tin solution with good deep plating ability, which is characterized in that it is prepared from the following raw materials: stannous methanesulfonate 100ml / L-300ml / L, methanesulfonic acid 70wt% 75ml / L- 150ml / L, isopropanol 10g / L~30g / L, sodium lauryl sulfate 1g / L~10g / L, p-methoxyphenol 0.5g / L~3g / L, quercetin 0.02g / L ~0.05g / L, 6‑phenyl‑2‑thiouracil 0.1g / L~0.2g / L, malic acid 0.2g / L~0.5g / L. The beneficial effect of the invention is that the deep-plating ability of the electroplating solution is greatly improved, it is very suitable for the plating of long tube-shaped workpieces, and the long-standing difficult technical problems in the prior art are solved.

The application relates to compounds with activity against infectious viruses. Accordingly, in one embodiment the invention provides a compound of the invention which is a compound of Formula I: (I) wherein: B is adenine, guanine cytosine, uracil, thymine, 7-deazaadenine, 7-deazaguanine, 7-deaza-8-azaguanine, 7-deaza-8-azaadenine, inosine, nebularine, nitropyrrole, nitroindole, 2-aminopurine, 2-amino-6-chloropuriine, 2,6-diaminopurine, hypoxanthine, pseudouridine, pseudocytosine, pseudoisocytosine, 5-propynylcytosine, isocytosines, isoguanine, 7-deazaguanine, 2-thiopyrimidine, 6-thioguanine, 4-thiothymine, 4-thiouracil O<6> -methylguanine, N<6> -methyladenine, O<4>-methylthymine, 5,6-dihydrothymine, 5,6-dihydroucacil, 4-methylindole, triazole, or pyrazolo[3,4-d]pyrimidine; and B is optionally substituted with one or more alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, hydroxy, or halo; and R<1> is alkyl, alkenyl, alkynyl, cyano, azido, or fluoromethyl; or a pharmaceutically acceptable salt or solvate thereof.

The invention discloses a preparation method of 2-thiouracil modified porous magnetic xanthan gum micro-spheres. The preparation method is characterized by including the steps: taking silicone oil as an organic phase, taking xanthan gum and nano-Fe3O4 magnetic particles as a water phase, spraying the water phase into the organic phase under the indoor temperature, separating solid and liquid, soaking a solid phase by the aid of deionized water for 24 hours, rapidly freezing soaked solid phase in a plastic container for 4 hours at the temperature of 18 DEG C below zero, placing the freezed solid phase into a freezing and drying oven after taking out, and freezing and drying the solid phase for 24 hours to obtain the porous magnetic xanthan gum micro-spheres; sequentially adding components into a reactor in weight percentage, dissolving 76-82% of N,N-dimethyl amide and 3-6% of 2-thiouracil, adding 10-16% of porous magnetic xanthan gum micro-spheres, stirring mixture, dripping 2.5-5% of Fumaryl chloride, performing reflux reaction for 2-3h at the temperature ranging from 48 DEG C to 52 DEG C, separating solid and liquid, and drying the separated solid to obtain the2-thiouracil modified porous magnetic xanthan gum micro-spheres. An adsorbent has high adsorption capacity for silver, can be repeatedly used and is low in cost, green and environmentally friendly, and the adsorbent has magnetism, so that the adsorbent is easily separated.

The invention discloses a paeonol dihydropyrimidinone derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: adding paeonol and a terminal dibromoalkane compound in an organic solvent and an acid binding agent to carry out Through a nucleophilic substitution reaction, brominated paeonol is generated; the aromatic aldehyde, ethyl cyanoacetate and thiourea are subjected to a cyclization reaction under an organic solvent and a catalyst to synthesize 6-substituted phenyl-5-cyano-2- thiouracil; finally, brominated paeonol and synthetic 6-substituted phenyl-5-cyano-2-thiouracil are substituted by nucleophilic under organic solvent and acid binding agent to synthesize paeonol Dihydropyrimidinone derivatives. The present invention provides a new class of paeonol dihydropyrimidinone derivatives, which have short preparation period, simple operation, low cost, and the obtained derivatives have high purity and stable quality; The introduction of a functional group dihydropyrimidinone on the phenol skeleton can improve the antitumor activity of the compound, which has further research significance.