Anti-diabetic drug containing wild chrysanthemum flower extract
A wild chrysanthemum extract and anti-diabetic technology are applied in the directions of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, which can solve the problems of low biological activity and poor agonistic activity, and achieve good development prospects and good blood sugar reduction. effect of effect
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Embodiment 1
[0029] This embodiment provides an antidiabetic drug containing the extract of Chrysanthemum officinalis, which consists of the extract of Chrysanthemum officinalis and / or a pharmaceutically acceptable carrier. Wild chrysanthemum extract contains sesquiterpenoids with the following structure:
[0030]
[0031] The above-mentioned wild chrysanthemum extract is prepared by the following method. In this example, the physiological activity analysis of the sesquiterpenoids in the wild chrysanthemum extract was also carried out.
[0032] The preparation method of wild chrysanthemum extract comprises the following steps:
[0033] (1) extraction
[0034] Weigh 7.0Kg of dried wild chrysanthemum, soak the dried wild chrysanthemum with 10L of ethanol (95%) at normal temperature and pressure for 24h, then filter, and collect the filtrate. Repeat the extraction of Flos Chrysanthemum for three times, combine the filtrates extracted three times, and then place the filtrate in a water b...
Embodiment 2
[0124] This example provides an anti-diabetic drug containing wild chrysanthemum flower extract, which contains compound 1 and / or a pharmaceutically acceptable carrier described in Example 1, and the active ingredient is compound 1.
[0125] From the test results in Example 1, it can be seen that the anti-diabetic drug containing wild chrysanthemum flower extract of this example has the effect of reducing the accumulation of oil droplets and triglycerides during the differentiation of 3T3-L1 preadipocytes, so it has a good hypoglycemic effect. It has a good development prospect in the treatment of diabetes.
Embodiment 3
[0127] This example provides an anti-diabetic medicine containing wild chrysanthemum flower extract, which contains compound 2 and / or a pharmaceutically acceptable carrier described in Example 1, and the active ingredient is compound 2.
[0128] From the test results in Example 1, it can be seen that the anti-diabetic drug containing wild chrysanthemum flower extract of this example has the effect of reducing the accumulation of oil droplets and triglycerides during the differentiation of 3T3-L1 preadipocytes, so it has a good hypoglycemic effect. It has a good development prospect in the treatment of diabetes.
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