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A kind of antidiabetic drug containing wild chrysanthemum extract

An anti-diabetic and wild chrysanthemum technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of low biological activity and poor activating activity, and achieve good development prospects and good hypoglycemic effects. Effect

Inactive Publication Date: 2019-12-20
广州市爱菩新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims at the problem that existing LXR agonists cannot enter into clinical trials due to their poor agonistic activity and low biological activity, and the attempts of LXR agonists to treat diabetes have not been successful. Antidiabetic drugs based on the LXR agonist GW395

Method used

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  • A kind of antidiabetic drug containing wild chrysanthemum extract
  • A kind of antidiabetic drug containing wild chrysanthemum extract
  • A kind of antidiabetic drug containing wild chrysanthemum extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This embodiment provides an antidiabetic drug containing the extract of Chrysanthemum officinalis, which consists of the extract of Chrysanthemum officinalis and / or a pharmaceutically acceptable carrier. Wild chrysanthemum extract contains sesquiterpenoids with the following structure:

[0030]

[0031] The above-mentioned wild chrysanthemum extract is prepared by the following method. In this example, the physiological activity analysis of the sesquiterpenoids in the wild chrysanthemum extract was also carried out.

[0032] The preparation method of wild chrysanthemum extract comprises the following steps:

[0033] (1) extraction

[0034] Weigh 7.0Kg of dried wild chrysanthemum, soak the dried wild chrysanthemum with 10L of ethanol (95%) at normal temperature and pressure for 24h, then filter, and collect the filtrate. Repeat the extraction of Flos Chrysanthemum for three times, combine the filtrates extracted three times, and then place the filtrate in a water b...

Embodiment 2

[0124] This embodiment provides an antidiabetic drug containing the extract of Chrysanthemum chrysanthemum, which contains compound 1 described in embodiment 1 and / or a pharmaceutically acceptable carrier, and the active ingredient is compound 1.

[0125] From the test results in Example 1, it can be seen that the antidiabetic drug containing the chrysanthemum extract of this example has the effect of reducing the accumulation of oil droplets and triglycerides in the differentiation process of 3T3-L1 preadipocytes, so it has a good hypoglycemic effect. It has a good development prospect in the treatment of diabetes.

Embodiment 3

[0127] This embodiment provides an antidiabetic drug containing the extract of Chrysanthemum chrysanthemum, which contains compound 2 described in embodiment 1 and / or a pharmaceutically acceptable carrier, and the active ingredient is compound 2.

[0128] From the test results in Example 1, it can be seen that the antidiabetic drug containing the chrysanthemum extract of this example has the effect of reducing the accumulation of oil droplets and triglycerides in the differentiation process of 3T3-L1 preadipocytes, so it has a good hypoglycemic effect. It has a good development prospect in the treatment of diabetes.

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Abstract

The invention specifically relates to an anti-diabetic drug containing wild chrysanthemum flower extract, belonging to the technical field of anti-diabetic drugs. The wild chrysanthemum flower extract in the anti-diabetic drug contains sesquiterpenoids disclosed in the invention; the sesquiterpenoids can substantially inhibit accumulation of triglyceride and total fat in the differentiation process of 3T3-L1 preadipocytes, and the inhibitory effect is superior to the inhibitory effect of a positive control compound, i.e., berberine; and the sesquiterpenoids can also obviously activate liver X receptors alpha and beta (LXR alpha and LXR beta), wherein the activation effect of the sesquiterpenoids is better than the activation effect of a conventional LXR agonist tool molecule GW3965, and in particular, a compound 4 has obviously better activation effect compared with GW3965. Moreover, the sesquiterpenoids can adjust the mRNA expression of transcription factors SREBP-1c, PPAR gamma and CEBP delta of vital importance to metabolism of cholesterol. Thus, the anti-diabetic drug containing the wild chrysanthemum flower extract in the invention has good hpyerglycemic effect and presents good development prospects in treatment of diabetes.

Description

technical field [0001] The invention relates to the technical field of antidiabetic drugs, in particular to an antidiabetic drug containing wild chrysanthemum extract. Background technique [0002] Diabetes is a systemic disease characterized by symptoms of chronic hyperglycemia. Its main risk lies in the complications it causes, the most common being foot disease, kidney disease, eye disease, encephalopathy, heart disease, skin disease, etc. Type 1 diabetes is caused by the autoimmune system destroying beta cells, resulting in a failure to produce insulin. The main cause of type 2 diabetes is that the cells no longer bind insulin, resulting in the body not being able to use insulin. More than 95% of diabetes is type 2 diabetes. Diabetes is the third leading killer after cancer and cardiovascular disease. It is estimated that by 2030, there will be 366 million people with diabetes worldwide. The incidence rate among Asians (10-12%) is higher than that among Europeans (4-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P3/10
Inventor 徐峻李婵娟顾琼
Owner 广州市爱菩新医药科技有限公司
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