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A method for extracting and isolating ketone from Tongkat Ali root

A technology of ketone and acetone, which is applied in the field of extraction and separation of ketone, can solve the problems of low yield, complicated extraction steps, unsuitable for industrial production, etc., and achieve the effects of high product content, high recovery rate, and simple operation

Active Publication Date: 2019-02-12
陕西嘉禾药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for extracting and separating euthanone from Tongkat Ali root, which mainly solves the problems in the prior art that the extraction steps are complicated, the yield is low, and it is not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1000kg Tongkat Ali root raw material is pulverized, the pulverized mesh number is 60 meshes, and the mass concentration of 4 times the raw material mass is used for 80% ethanol stirring and extraction, and the extraction is performed twice, and the extraction time is 1 hour each time; after extraction, filter and concentrate to Alcohol-free, set aside.

[0033] The above-mentioned extraction concentrated solution was added with 0.5% cationic flocculant with a mass concentration of 0.1% under the condition of 5°C, stirred for 30 minutes, left for 0.5 hours, and filtered.

[0034] Filter through a membrane with a molecular weight cut-off of 100, discard the dialysate, and continue to filter the concentrated solution (reflux liquid) with a membrane with a molecular weight cut-off of 500 to collect the dialysate.

[0035] Adjust the pH of the above dialysate to 8, collect the precipitate, and dry the precipitate for later use.

[0036] The above precipitate was crushed to ...

Embodiment 2

[0039] 1000kg raw material of Tongkat Ali root is crushed, the crushed mesh is 80 mesh, and the mass concentration of 90% ethanol is used to stir and extract 5 times the mass of the raw material, and the extraction is 3 times, and the extraction time is 2.5 hours each time; after the extraction, filter and concentrate To no alcohol, place.

[0040] The above-mentioned extract concentrate was added with 5% liquid mass concentration of 3% anionic flocculant at 80°C, stirred for 20 minutes, left for 2 hours, and filtered.

[0041] Filter with a membrane with a molecular weight cut off of 300, discard the dialysate, and continue to filter the concentrated solution (reflux liquid) with a membrane with a molecular weight cut off of 700 to collect the dialysate.

[0042] Adjust the pH of the above dialysate to 10, collect the precipitate, and dry the precipitate for later use.

[0043] Crush the above precipitate to 100 mesh, stir and dissolve with a mixed solvent of ethyl acetate a...

Embodiment 3

[0046] 1000kg raw material of Tongkat Ali root is pulverized, the crushed mesh is 70 meshes, and 85% ethanol is used to stir and extract 4.5 times the mass of the raw material, and the extraction is performed 3 times, and the extraction time is 1 hour each time; after the extraction, it is filtered and concentrated to no alcohol. place.

[0047] The above-mentioned extract concentrate, under the condition of 25 ° C, first add 1% of the liquid mass concentration of 2.0% anionic flocculant and stir for 40 minutes, and then add 1.5% of the liquid mass of 0.5% cationic flocculant and stir for 30 minutes, Standing time is 1h, filter.

[0048] Filter through a membrane with a molecular weight cut-off of 200, discard the dialysate, continue to filter the concentrated solution (reflux liquid) with a membrane with a molecular weight cut-off of 600, and collect the dialysate.

[0049] Adjust the pH of the above dialysate to 9, collect the precipitate, and dry the precipitate for later ...

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Abstract

The invention provides a method for extracting and separating eurycomanone from eurycoma longifolia root. The method comprises the following steps: grinding the raw material eurycoma longifolia root, stirring and extracting with ethanol, filtering, concentrating until no alcohol exists, and placing for later use; adding a flocculating agent or clarifying agent to remove impurities; filtering with a membrane with molecular weight cutoff of 100-300; discarding the dialysis liquid, filtering the concentrate with a membrane with molecular weight cutoff of 500-700, and collecting the dialysis liquid; adjusting the pH of the obtained dialysis liquid to 8-10; collecting the sediment and drying the sediment for later use; stirring and dissolving with one or more of ethyl acetate, acetone and ethanol, and filtering to obtain dissolution residue and dissolution liquid; finally, dissolving the dissolution residue with acetone; after dissolving is completed, adding acetone in a stirring condition, placing, and filtering to obtain crystal, i.e., eurycomanone. The method provided by the invention is easy to operate, the product content and the recovery rate are high, the product yield is 0.10-0.25%, the content is over 98.8%, and the method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of extraction and separation of sterone compounds, and relates to a method for extracting and separating ketone, in particular to a method for extracting and separating ketone from Tongkat Ali root. Background technique [0002] Tongkat Ali is a plant of the genus Tongkat Ali in the bitter wood family, and is widely used in Southeast Asian countries such as Malaysia, Indonesia, and Vietnam. It is known as Malaysian ginseng, natural Viagra, etc. in the place of origin, and is known as the three major national treasures of Malaysia together with bird's nest and tinware. In addition to anti-cancer, anti-malarial, and improvement of male sexual dysfunction, Tongkat Ali can also improve human body function, anti-anxiety, anti-osteoporosis, analgesic and anti-inflammatory, antibacterial, anti-parasite, immune regulation, anti-vascular Formation and treatment of diabetes. Tetanone is one of the most representative substanc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/10
CPCC07D493/10
Inventor 肖红王晓莹张瑜郭伟妮张利娜
Owner 陕西嘉禾药业有限公司
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