Carboxymethylated lachnum extracellular polysaccharide and application of carboxymethylated lachnum extracellular polysaccharide to hypoglycemic drug

A technology of Trichomyces granulosa and exopolysaccharide, which is applied in the field of carboxymethylated Trichomyces granulosa exopolysaccharide and its use as a hypoglycemic drug, can solve the problems of patients' health damage, achieve no toxic side effects, improve Hypoglycemic activity, effects of improving glucose tolerance and body weight

Inactive Publication Date: 2017-06-13
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chemical drugs include sulfonylureas, biguanides, thiazolidinediones, α-glucosidase inhibitors, etc. However, these chemical drugs have side effects and cause damage to the health of patients
At present, there is no published literature mentioning that the exopolysacc

Method used

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  • Carboxymethylated lachnum extracellular polysaccharide and application of carboxymethylated lachnum extracellular polysaccharide to hypoglycemic drug
  • Carboxymethylated lachnum extracellular polysaccharide and application of carboxymethylated lachnum extracellular polysaccharide to hypoglycemic drug
  • Carboxymethylated lachnum extracellular polysaccharide and application of carboxymethylated lachnum extracellular polysaccharide to hypoglycemic drug

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Embodiment 1

[0012] (1) Preparation of exopolysaccharide (LEP) from Trichodia granulosa

[0013] The strain preservation number is CCTCC M 2016603 Trichodia granulosus YM216 was inoculated in a 100L fermenter, the volume ratio of the filling coefficient was 0.7, the inoculum size was 5% (v / v), the culture temperature was 26°C, and the ventilation rate was 1.0 L / min, the stirring speed is 180r / min, the fermentation time is 10d, and the medium formula is: anhydrous glucose 30g L -1 , yeast extract 5g·L -1 , MgSO 4 ·7H 2 O 1g L -1 , KH 2 PO 4 1g·L -1 , V B1 50mg·L -1 , natural pH, filter the fermentation broth with suction, collect the fermentation broth, concentrate by low-pressure rotary evaporation at 60°C, add 4 times the volume of 95% ethanol for alcohol precipitation for 24 hours, 4500r min -1 Centrifuge for 8 minutes, pour off the supernatant, redissolve the precipitate with 5 times the volume of distilled water to obtain the crude polysaccharide aqueous solution, add 1 / 10 vol...

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Abstract

The invention discloses a carboxymethylated lachnum extracellular polysaccharide prepared by modifying a lachnum YM216 extracellular polysaccharide with the strain preservation number of CCTCC (China Center For Type Culture Collection) M 2016603, and application of the carboxymethylated lachnum extracellular polysaccharide to a hypoglycemic drug. A pharmacodynamics test shows that the carboxymethylated lachnum extracellular polysaccharide can be used for remarkably improving the glucose tolerance and body weight of type II diabetic mice induced by high-fat feed and streptozotocin and lowering glycosylated hemoglobin, fasting plasma glucose levels and serum insulin levels, and has a good blood glucose lowering function; furthermore, the carboxymethylated lachnum extracellular polysaccharide can be used for up-regulating the expression of glucokinase and adenosine monophosphate-activated protein kinase and down-regulating the expression of 6-phosphatase. By adopting the method disclosed by the invention, the blood glucose lowering activity of an original lachnum extracellular polysaccharide can be improved; the carboxymethylated lachnum extracellular polysaccharide has no toxic side effect and has positive meanings on an application range of the polysaccharide.

Description

technical field [0001] The invention belongs to the technical field of application of carboxymethylated Trichodesia exopolysaccharide in preparation of medicines, and in particular relates to carboxymethylated Trichodesma exopolysaccharide and its use as a hypoglycemic drug. Background technique [0002] Polysaccharides widely exist in higher plants, algae, fungi and animals, and are one of the most abundant biopolymers in nature. Diabetes is a series of metabolic disorders of sugar, protein, fat, water and electrolytes caused by relative or absolute deficiency of insulin secretion or defect of insulin action. Treatment for diabetes usually includes exercise, diet, oral hypoglycemic drugs, and insulin therapy. Chemical drugs include sulfonylureas, biguanides, thiazolidinediones, α-glucosidase inhibitors, etc. However, these chemical drugs have side effects and cause damage to the health of patients. In recent years, polysaccharides that can treat diabetes and have no toxic...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P3/10C12P19/04C12R1/645
CPCC08B37/0003A61K31/715C08B37/00C12P19/04
Inventor 叶明王玉芬候国华李井雷杨柳
Owner HEFEI UNIV OF TECH
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