Application of Aidi preparation in preparation of anti-malignant pleural mesothelioma medicine

A preparation and malignant technology, applied in the application field of Aidi preparation in the preparation of anti-malignant pleural mesothelioma drugs, can solve the problems of malignant pleural mesothelioma being insensitive to chemotherapy and lack of chemotherapy drugs, etc.

Active Publication Date: 2021-01-05
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, malignant pleural mesothelioma is not sensitive to chemotherapy, and currently there is no optimal chemotherapy drug

Method used

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  • Application of Aidi preparation in preparation of anti-malignant pleural mesothelioma medicine
  • Application of Aidi preparation in preparation of anti-malignant pleural mesothelioma medicine
  • Application of Aidi preparation in preparation of anti-malignant pleural mesothelioma medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1: the preparation of Aidi injection (low component)

[0076] Raw materials: Mylabris 4g, Ginseng 200g, Astragalus 450g, Acanthopanax 900g

[0077] Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentrated solutio...

Embodiment 2

[0078] Embodiment 2: the preparation of Aidi injection

[0079] Raw materials: Mylabris 5g, Ginseng 250g, Astragalus 500g, Acanthopanax 1000g

[0080]Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentrated solution to a volume of...

Embodiment 3

[0081] Embodiment 3: the preparation of Aidi injection

[0082] Raw materials: Mylabris 10g, Ginseng 300g, Astragalus 750g, Acanthopanax 1250g

[0083] Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentrated solution to a volume ...

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Abstract

An application of Aidi preparation in the preparation of anti-malignant pleural mesothelioma medicines. The Aidi preparation disclosed by the invention is composed of mylabris, ginseng, astragalus and Acanthopanax four herbs; the Aidi preparation of the present invention has stronger The anti-malignant pleural mesothelioma has significant drug efficacy, less side effects, and safer clinical medication, which provides a new therapeutic approach for the treatment of malignant pleural mesothelioma and expands the clinical application of Aidi preparations.

Description

technical field [0001] The invention relates to a new application of Aidi preparation, in particular to the application of Aidi preparation in the preparation of anti-malignant pleural mesothelioma drugs. Background technique [0002] Malignant pleural mesothelioma (MPM) is a malignant tumor derived from pleural mesothelial cells and is a primary tumor of the pleura. It is characterized by low incidence, difficulty in early diagnosis, local invasion, and poor prognosis. In recent decades, the incidence has gradually increased worldwide. According to histomorphological classification, MPM can be divided into three types: epithelial type, sarcomatoid (fibrous type) and mixed type, and the epithelial type is more common. The most common cause of MPM is exposure to asbestos, in addition to infection with tuberculosis, rhesus virus 40, and exposure to nonspecific industrial compounds such as glass fibers, radiation, and zeolites. At present, European and American countries have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/481A61P35/00A61K35/64
CPCA61K9/0019A61K9/08A61K36/254A61K36/258A61K36/481A61K2300/00
Inventor 窦啟玲隋东虎张圣贵
Owner GUIZHOU YIBAI PHARMA CO LTD
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