Toothpaste for preventing and/or treating oral ulcers, and making method thereof
A technology for oral ulcers and toothpaste, which is applied in the field of toothpaste for the prevention and treatment of oral ulcers and its preparation, can solve the problems of poor targeting of antibacterial active ingredients, reduced self-healing ability of oral tissues, and unacceptable taste to consumers. Achieve the effects of improving the use effect and taste, inhibiting demineralization, preventing and treating dental caries
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Embodiment 1
[0033] The preparation of embodiment 1 illite microbead
[0034] (1) Preparation of illite ultra-pure powder: take illite raw ore, carry out high-speed impact crushing, then use cyclone to classify and remove impurities, remove metal elements by magnetic separation, add purified water for wet flotation, after standing for 24 hours, remove The supernatant and sediment are taken from the middle layer to dry, and then pulverized again in a high-speed vortex mill to obtain ultra-pure illite powder.
[0035] (2) Preparation of hollow microspheres: Add deionized water to illite ultrapure powder to make a suspension with a mass concentration of 2% (m / v), ultrasonically treat it for 30 minutes, then seal it in a high-pressure steam boiler, and heat it at 180°C Treat at low temperature for 10 h, cool to room temperature, centrifuge to collect the precipitate, wash twice with deionized water and absolute ethanol respectively, and vacuum dry at 80° C. for 6 h to obtain hollow microsphere...
Embodiment 2
[0038] The preparation of embodiment 2 amorphous calcium phosphate microspheres
[0039]
[0040] Preparation of group A amorphous calcium phosphate microspheres:
[0041] (1) Dissolve calcium chloride in water to make an aqueous calcium chloride solution, then add isooctyl ether phosphate to the calcium chloride aqueous solution, stir until the material is completely dissolved, and the isooctyl ether phosphate and chloride The molar ratio of calcium is 0.05:1;
[0042] (2) Dissolve sodium phosphate in water to make an aqueous solution of sodium phosphate, then add dropwise to the solution prepared in step (1), the mol ratio of the sodium phosphate to calcium chloride is 0.6:1, stir evenly, and then Add polylactic acid with a final concentration of 8% (m / v), conduct a microwave-assisted hydrothermal reaction at 100°C for 45 minutes, cool to room temperature, and centrifuge to collect the precipitate;
[0043] (3) The precipitate obtained in step (2) was washed 3 times wit...
Embodiment 3-6
[0046] The preparation of embodiment 3-6 preventing and treating oral ulcer toothpaste
[0047] The illite microspheres in the raw materials of the toothpaste for preventing and treating oral ulcers in Examples 3-6 of the present invention are obtained in Example 1; the amorphous calcium phosphate microspheres are obtained in Group D of Example 2. The components and contents thereof for the prevention and treatment of oral ulcers in each embodiment are shown in the table below:
[0048] Components and their parts Example 3 Example 4 Example 5 Example 6 sodium pyrophosphate 3 2 4 3 illite microbeads 30 25 20 18 Sucrose Acetate Isobutyrate 5 6 4 3 sodium pyruvate 1 2 1 3 2-Hydroxyethyl methacrylate 6 8 2 5 Amorphous calcium phosphate microspheres 20 25 15 22 Sodium Lauroyl Glutamate 3 2 1 4 disodium stannous citrate 2 1 2 3 Sodium carboxymethyl cellulose 46 44 40 42 glycerin 1...
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