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Toothpaste for preventing and/or treating oral ulcers, and making method thereof

A technology for oral ulcers and toothpaste, which is applied in the field of toothpaste for the prevention and treatment of oral ulcers and its preparation, can solve the problems of poor targeting of antibacterial active ingredients, reduced self-healing ability of oral tissues, and unacceptable taste to consumers. Achieve the effects of improving the use effect and taste, inhibiting demineralization, preventing and treating dental caries

Inactive Publication Date: 2017-07-14
缪来耿 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the following problems generally exist in traditional Chinese medicine toothpaste: First, the addition of active ingredients in toothpaste is random, some are based on the suggestions of Chinese medicine practitioners, some are based on folk prescriptions, and some are based on the popularity of certain Chinese herbal medicines among the people, etc., rarely Tested and compared
Secondly, some traditional Chinese medicine toothpaste contains too many prescription flavors of traditional Chinese medicine, resulting in complex composition of ingredients, which makes the content of active ingredients in toothpaste, which is limited in content, even lower.
In addition, the antibacterial active ingredients used are not well targeted, and most of them have broad-spectrum antibacterial properties, and have inhibitory effects on various bacteria in the oral cavity, including non-pathogenic resident bacteria in the oral cavity.
The resident bacteria are important colonies that maintain the oral micro-ecological balance. If they are suppressed for a long time, it is easy to reduce the self-healing ability of oral tissues to damage
Finally, the taste of certain traditional Chinese medicines is not easily accepted by consumers

Method used

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  • Toothpaste for preventing and/or treating oral ulcers, and making method thereof
  • Toothpaste for preventing and/or treating oral ulcers, and making method thereof
  • Toothpaste for preventing and/or treating oral ulcers, and making method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 illite microbead

[0034] (1) Preparation of illite ultra-pure powder: take illite raw ore, carry out high-speed impact crushing, then use cyclone to classify and remove impurities, remove metal elements by magnetic separation, add purified water for wet flotation, after standing for 24 hours, remove The supernatant and sediment are taken from the middle layer to dry, and then pulverized again in a high-speed vortex mill to obtain ultra-pure illite powder.

[0035] (2) Preparation of hollow microspheres: Add deionized water to illite ultrapure powder to make a suspension with a mass concentration of 2% (m / v), ultrasonically treat it for 30 minutes, then seal it in a high-pressure steam boiler, and heat it at 180°C Treat at low temperature for 10 h, cool to room temperature, centrifuge to collect the precipitate, wash twice with deionized water and absolute ethanol respectively, and vacuum dry at 80° C. for 6 h to obtain hollow microsphere...

Embodiment 2

[0038] The preparation of embodiment 2 amorphous calcium phosphate microspheres

[0039]

[0040] Preparation of group A amorphous calcium phosphate microspheres:

[0041] (1) Dissolve calcium chloride in water to make an aqueous calcium chloride solution, then add isooctyl ether phosphate to the calcium chloride aqueous solution, stir until the material is completely dissolved, and the isooctyl ether phosphate and chloride The molar ratio of calcium is 0.05:1;

[0042] (2) Dissolve sodium phosphate in water to make an aqueous solution of sodium phosphate, then add dropwise to the solution prepared in step (1), the mol ratio of the sodium phosphate to calcium chloride is 0.6:1, stir evenly, and then Add polylactic acid with a final concentration of 8% (m / v), conduct a microwave-assisted hydrothermal reaction at 100°C for 45 minutes, cool to room temperature, and centrifuge to collect the precipitate;

[0043] (3) The precipitate obtained in step (2) was washed 3 times wit...

Embodiment 3-6

[0046] The preparation of embodiment 3-6 preventing and treating oral ulcer toothpaste

[0047] The illite microspheres in the raw materials of the toothpaste for preventing and treating oral ulcers in Examples 3-6 of the present invention are obtained in Example 1; the amorphous calcium phosphate microspheres are obtained in Group D of Example 2. The components and contents thereof for the prevention and treatment of oral ulcers in each embodiment are shown in the table below:

[0048] Components and their parts Example 3 Example 4 Example 5 Example 6 sodium pyrophosphate 3 2 4 3 illite microbeads 30 25 20 18 Sucrose Acetate Isobutyrate 5 6 4 3 sodium pyruvate 1 2 1 3 2-Hydroxyethyl methacrylate 6 8 2 5 Amorphous calcium phosphate microspheres 20 25 15 22 Sodium Lauroyl Glutamate 3 2 1 4 disodium stannous citrate 2 1 2 3 Sodium carboxymethyl cellulose 46 44 40 42 glycerin 1...

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Abstract

The invention relates to a toothpaste for preventing and / or treating oral ulcers, and a making method thereof. The toothpaste comprises, by mass, 1-4 parts of sodium pyrophosphate, 15-30 parts of illite microbeads, 2-6 parts of sucrose acetate isobutyrate, 1-3 parts of sodium pyruvate, 2-8 parts of poly(2-hydroxyethyl methacrylate), 10-25 parts of amorphous calcium phosphate microspheres, 1-4 parts of sodium lauroylglutamate, 1-3 parts of disodium stannous citrate and 50-70 parts of a matrix. The toothpaste has strong cleaning ability to the oral cavity, can effectively inhibit oral bacteria, effectively prevents oral ulcers and keeps the breath fresh. The toothpaste has the advantages of uniform texture , delicate taste, rich foams, stable properties, no layering or water separation after long-term storage, effective keeping of a healthy oral environment after long-term use, and tooth care.

Description

technical field [0001] The invention belongs to the field of oral care, and in particular relates to a toothpaste for preventing and or treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral disease, caused by viruses or bacteria, generally caused by streptococcus, staphylococcus aureus, and Escherichia coli. It is a localized oral mucosal ulcer injury characterized by periodic recurrence. Can occur anywhere in the oral mucosa. It is more common in the mucous membranes of the lips, cheeks, soft palate, or gums of the oral cavity, where single or multiple round or oval ulcers of various sizes occur, the surface is covered with gray or yellow pseudomembrane, the center is depressed, the boundary is clear, and the surrounding mucosa is red And slightly swollen, ulcer local causalgia is obvious, has the feature of periodicity, recurrence, self-limiting. Patients with severe oral ulcers may also be accompanied by complic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/26A61K8/24A61Q11/00A61P1/02
CPCA61K8/64A61K8/24A61K8/26A61Q11/00
Inventor 缪来耿
Owner 缪来耿
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