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A high-efficiency anti-alcoholic and liver-protecting composition, its preparation method and application

A technology of anti-alcohol and liver-protecting composition, which is applied in the field of high-efficiency anti-alcohol and liver-protecting composition, and can solve problems such as aggravating liver and kidney metabolic burden damage

Active Publication Date: 2020-07-17
王华杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anti-alcoholic products in the market are chemical drugs and Chinese patent medicine preparations. While anti-alcoholic, they will increase the metabolic burden of the liver and kidneys to varying degrees and cause varying degrees of damage.

Method used

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  • A high-efficiency anti-alcoholic and liver-protecting composition, its preparation method and application
  • A high-efficiency anti-alcoholic and liver-protecting composition, its preparation method and application
  • A high-efficiency anti-alcoholic and liver-protecting composition, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of the extract of grape leaves of Snake tooth

[0023] The dehydrated snakehead grape leaves are crushed through a 24-mesh sieve. Weigh 5.8 kg of coarse powder, add 70% ethanol to soak for 30 minutes according to the ratio of liquid to material (v / m) 30:1, ultrasonically extract 3 times, each time for 20 minutes, collect the extract, concentrate under reduced pressure, dry, and pulverize through 80 mesh Sieve the extract 2000g. After testing: the mass percentage content of the total flavonoids of the extract is 36.2%, and the mass percentage content of dihydromyricetin is 28.2%.

Embodiment 2

[0024] Example 2: Preparation of Hovenia dulcis Fructus Extract

[0025] The Hovenia dulcis seeds are crushed through a 24-mesh sieve. Weigh 16.5kg of coarse powder, add 70% ethanol according to the ratio of material to liquid (m / v) 1:8, and extract under reflux at 80°C for 3 times, each time for 1.5h. The three extracts were combined, concentrated to dryness under reduced pressure, dried at 105°C for 3 hours, cooled to room temperature, crushed and passed through a 80-mesh sieve to obtain 1600g of the extract. After testing: the mass percent content of total flavonoids in the extract is 8.3%.

Embodiment 3

[0026] Embodiment 3: the preparation of Acai fruit instant powder

[0027] Wash the fresh Acai fruits and pick out the inferior ones. Weigh 4100g of high-quality fresh fruit and place it in a beater for beating, filter to remove residue, and concentrate the filtrate to a relative density of 1.20 (20°C). The concentrated filtrate was added with xylitol and methylcellulose according to mass percentage (m / m) 88%:12%, fully stirred and mixed, dried, pulverized and passed through an 80 mesh sieve to obtain 1200g of Acai fruit instant powder.

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Abstract

The invention discloses a high-efficiency alcohol effect dispelling and liver protecting composition, and a preparation method and an application thereof. The composition comprises, by weight, 280-390 parts of dehydrated Ampelopsis grossedentata leaves, 210-580 parts of Hovenia acerba Lindl., 140-300 parts bof corn oligopeptide powder and 90-130 parts of Acai instant powder, wherein the dehydrated Ampelopsis grossedentata leaves undergoes ultrasonic extraction, the content of total flavonoids in the obtained extract is not less than 35%, and the content of dihydromyricetins is 25-32%; the Hovenia acerba Lindl. undergoes ethanol refluxing extraction, and the content of total flavonoids in the obtained extract is not less than 8%; and the Acai instant powder is prepared through Acai beating, filtering for residue removal, filtrate concentration, auxiliary material adding, and mixing and drying. A result of test shows that the composition significantly degrades ethanol in rat blood, continuously enhances the activity of ADH in liver of mice, effectively prevents alcohol-induced liver GSH depletion and MDA increase, reduces the TG content, and has good alcoholic liver injury prevention and treatment effects.

Description

technical field [0001] The invention relates to a high-efficiency anti-alcohol and liver-protecting composition. In particular, it relates to a compatible composition of grape leaves, Hovenia dulcis, corn oligopeptide powder and acai fruit instant powder, as well as its preparation method and application. [0002] technical background [0003] Drinking a small amount of alcohol can promote blood circulation, dredge collaterals, and dispel cold, while excessive drinking can produce "alcoholism" (being commonly called as drunkenness). Medically, alcoholism is divided into two types: acute alcoholism and chronic alcoholism. Among them, acute alcoholism refers to the clinical symptoms of nausea, vomiting, dizziness, delirium, agitation, coma, incontinence, respiratory depression and even death brought to patients in a short period of time after excessive drinking; chronic alcoholism refers to the clinical symptoms caused by long-term overdose Drinking alcohol, the ethanol that ...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61P39/02A61P1/16A23L33/105A23L33/18A23L19/00A61K36/889
CPCA23V2002/00A61K36/72A61K36/87A61K36/889A61K38/02A61K2300/00A23V2200/334A23V2200/30A23V2250/21A23V2250/55
Inventor 龙祥张伟平青字芳潘丽婷
Owner 王华杰
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