High-throughput micron particle circular sorting and concentrating device and manufacturing method thereof

Abstract

The invention discloses a high-throughput micron particle circular sorting and concentrating device and a manufacturing method thereof. The device is connected with an inner discharging solution collection bottle (8), a one-way valve (9), a peristaltic pump (1), a flow allocating joint (2) and a multilayer overlapped microfluidic chip (3) in sequence, wherein the multilayer overlapped microfluidic chip (3) is provided with an extracellular fluid outlet (16) and an intracellular fluid outlet (17) which are connected with an outer discharging solution collection bottle (7) and the inner discharging solution collection bottle (8); moreover, the components are connected through connection hoses (10 to 14). The manufacturing method comprises the following steps: 1) manufacturing the multilayer overlapped microfluidic chip (3); (3) connecting the components through the connection hoses (10 to 14). The method has the advantages of easiness, stable sorting, high throughput and high concentration efficiency, can be used for realizing sorting and concentration of micron-sized biological particles by using a micro-fluid inertial effect, and can be widely applied to medical diagnosis of blood cells and the like and environmental detection of alga living creatures.

Description

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AI Technical Summary

Benefits of technology

This patented new type of fluidics system uses tiny channels that are arranged like helixes or circles around them instead of rectangular boxes. These small spaces allow fluids to pass more easily without being blocked by other things during their passage. They make it easier to sort large numbers of samples quickly while still maintaining its accuracy level. Overall this design makes processing faster and less expensive than previous systems.

Problems solved by technology

Technics: Current techniques involve analyzing tiny objects like microspheres suspended in liquids called slurry. These techniques suffer limitations due to instabilities associated with particle movement and lack of sufficient accuracy. There is an urgent demand for improved devices capable of efficiently separating minute amounts of materials while maintaining accurate results without causing damages to sensitive areas inside the apparatus itself.

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