A 3D printing device and method for a tissue engineering scaffold

Abstract

The invention discloses a 3D printing device and method of tissue engineering scaffolds. The device comprises a printing module, a spray-coating module, a cell implantation module, a printing platform and a temperature control module. The printing module is a squeezing printing device composed of one or more sprayer devices, and is used for squeezing printing of the tissue engineering scaffold with a three-dimensional macrostructure. The spray-coating module is a spray-coating device provided with one or more nozzles, and is used for forming the tissue engineering scaffold with a two-dimensional macrostructure. The cell implantation module is an ink jet printing device with one or more nozzles and used for spraying micro-droplets containing seed cells so as to complete implantation of cells and growth factors corresponding to the tissue engineering scaffolds. The printing platform is located under the printing module, and the tissue engineering scaffolds are formed on the printing platform. The temperature control module is used for providing an environment-controllable printing environment. The tissue engineering scaffolds which are made of various materials, formed at a time through various technologies are complex in structure can be obtained.

Description

Technical field [0001] The invention relates to a 3D printing device and method for a tissue engineering scaffold. Background technique [0002] The causes of human tissue defects include congenital malformations, trauma, surgery, etc. Although the human body's ability to repair itself is limited, most of them need to be repaired by other methods. The human body's ability to reject rejection often has limitations in xenotransplantation and artificial composite repair, requiring autologous transplantation for repair. However, autologous transplant surgery often has a long course of disease, which brings huge pain and heavy economic burden to the patient; or it causes short-term damage to the patient, the operation is difficult, and the risk is high, and conservative treatments such as amputation are often necessary. [0003] Tissue engineering is an emerging discipline that combines cell biology and material science to construct tissues or organs in vitro or in vivo. Tissue engine...

AI Technical Summary

Problems solved by technology

At present, the manufacturing process of scaffolds in experiments often focuses on the manufacture of one or a few types of tissues, and the manufactured scaffolds are often simple in structure and single in shape, and it is difficult to realize the fabrication of complex structural scaffolds with free shapes, multiple or even all tissue combinations

In particular, bone tissue, as a support structure with high mechanical strength, often needs to be made of materials such as ceramics and metals. The manufacturing process is high in temperature and takes a long time, and it is difficult to make it together with other tissues at one time.

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