Application of fructus lycii water decoction in preparing drug for treating retinal tissue injury caused by heroin

A technology of tissue damage and water decoction, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve problems affecting human health and social stability, and achieve the effects of cheap drugs, convenient materials, and protective effects

Inactive Publication Date: 2017-08-18
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the abuse and misuse of stimulants such as heroin are relatively common, and adverse reactions occur frequently, seriously affecting human health and social stability
Methadone, clonidine and other drugs are commonly used at home and abroad to eliminate stimulant addiction or withdrawal symptoms, but these drugs themselves have certain problems of addiction and drug resistance, so the selection of drugs with less toxic side effects, less dependence and Traditional Chinese medicine with low drug resistance is of great significance for reducing or reducing the damage caused by excitatory drugs to the tissues and organs of the body
There is no special curative effect of traditional Chinese medicine against retinal tissue damage caused by heroin

Method used

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  • Application of fructus lycii water decoction in preparing drug for treating retinal tissue injury caused by heroin
  • Application of fructus lycii water decoction in preparing drug for treating retinal tissue injury caused by heroin
  • Application of fructus lycii water decoction in preparing drug for treating retinal tissue injury caused by heroin

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Embodiment Construction

[0031] Below in conjunction with embodiment further illustrate the present invention.

[0032] The preparation method of medicinal liquid of the present invention

[0033] According to the traditional Chinese medicine decoction preparation method, take 100g of Ningxia wolfberry, add 1L of water to soak for 1h, boil for 30min, filter the medicinal juice, add water to the dregs and decoct for 30min to filter the medicinal juice, combine the medicinal liquid twice, and then use a rotary evaporator to decoct the medicinal juice. The decoction was concentrated to make 0.2~0.4g / mL crude drug water decoction for the following tests.

[0034] Protective effect of Lycium barbarum decoction on retinal damage caused by heroin

[0035] A total of 120 Kunming mice born 10 days old were selected and randomly divided into blank control group, experimental control (heroin) group, wolfberry water decoction (heroin + wolfberry) 1 and 2 groups. The experimental control group and Lycium barbaru...

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Abstract

The invention discloses application of a fructus lycii water decoction in preparing drug for treating retinal tissue injury caused by heroin. The fructus lycii water decoction is a crude drug water decoction containing 0.2-0.4g / mL of crude drug. A great number of studies on fructus lycii find that the fructus lycii water decoction can improve SOD activity of tissue cells, inhibit cell lipid peroxidation and inflammatory reaction of, inhibit iNOS activity of the cells, reduce tissue structure injury, reduce expression of Bax, Caspase-3, TNF-alpha and NF-kappa B and improve cell activity, has anti-oxidation effect, anti-inflammatory effect and retina protecting effect and can effectively retard or relieve injury of retinal tissue caused by heroin. New application is added to the fructus lycii water decoction, and the application is of certain reference significance in developing and utilizing fructus lycii medicinal resources with western characteristics in the future.

Description

technical field [0001] The invention relates to a decoction of traditional Chinese medicine, in particular to the use of a decoction of wolfberry in the preparation of a medicine for treating retinal tissue damage caused by heroin. Background technique [0002] Heroin is diacetylmorphine, which is a serious life-threatening opioid substance, which can easily pass through the blood-brain barrier and combine with opioid receptors in the central nervous system and peripheral tissues. It has a strong stimulant effect. If it is used for a long time or improperly, it will cause serious drug dependence, overexcite the central nervous system, interfere with the balance of the body's antioxidant system and the normal expression of related specific proteins, and cause pathological damage to the body's tissue structure. Therefore, it is of great significance for the development of medicine to study the protective effect of Chinese herbal medicine on animals or human body, and to develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P9/10
CPCA61K36/815A61K2236/331
Inventor 俞诗源苟陶然李重阳
Owner NORTHWEST NORMAL UNIVERSITY
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