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A method for breaking the wall of ganoderma lucidum spores and the prepared broken ganoderma spore powder and application thereof

A technology of broken Ganoderma lucidum spore powder and broken Ganoderma lucidum spores, which can be used in medical formulas, medical preparations containing active ingredients, grain processing, etc., and can solve the problems of high destructive power of active substances, loss of active substances, and low wall breaking rate, etc. problems, to achieve the effect of retaining the content and activity of active ingredients, protecting the liver from damage, and high tumor inhibition rate

Active Publication Date: 2021-02-26
BEIJING FUNAKANG BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the wall-breaking rate of ultrafine pulverization, homogenization, ultrasonic, and high-energy ball milling impact method is relatively low, and the ultrafine pulverization method, high-energy ball milling impact method and ultrasonic wall-breaking method are not effective for active substances. The destructive power is relatively large, and it is easy to deteriorate the active substance
However, the wall-breaking process of the germination breaking method is longer, the operation is cumbersome, it is not suitable for large-scale processing, and the breaking rate is relatively low.
There are too many influencing factors in the method of biological enzyme wall breaking, among which the amount of enzyme, temperature, pH value, time, etc. will all affect the efficiency of wall breaking, so the practicability is not strong
CO 2 The supercritical wall-breaking process is carried out under ultra-high pressure, CO 2 Under critical liquid conditions, a large amount of fatty acid active substances will be released, resulting in the loss of active substances

Method used

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  • A method for breaking the wall of ganoderma lucidum spores and the prepared broken ganoderma spore powder and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1 g fullerene C 60 Fully mix and ball-mill with 100g Ganoderma lucidum spore powder in a ball mill, then place the mixed powder in a high-pressure reactor, pressurize to 5GPa, maintain the pressure for 4h, and then quickly depressurize (0.7GPa / min) to normal pressure. After the decompression is over, take out the mixed powder and add 80°C water to fully stir, and perform centrifugation, repeat 3-5 times; because fullerene is insoluble in water, it will deposit at the bottom, collect soluble matter - supernatant After drying (drying at 40° C. for 12 h), the broken ganoderma spore powder was prepared.

Embodiment 2

[0058] 1 g fullerene C 60 Mix well with 500g Ganoderma lucidum spore powder in a ball mill, then place the mixed powder in a high-pressure reactor, pressurize to 10GPa, maintain the pressure for 5h, and then quickly depressurize (1GPa / min) to normal pressure. After the decompression is over, take out the mixed powder and add 80°C water to fully stir, and perform centrifugation, repeat 3-5 times; because fullerene is insoluble in water, it will deposit at the bottom, collect soluble matter - supernatant After drying (drying at 40° C. for 12 h), the broken ganoderma spore powder was prepared.

Embodiment 3

[0060] 1 g fullerene C 70 Fully mix and ball-mill with 300g of Ganoderma lucidum spore powder in a ball mill, then place the mixed powder in a high-pressure reactor, pressurize to 9GPa, maintain the pressure for 5h, and then quickly depressurize (0.8GPa / min) to normal pressure. After the decompression is over, take out the mixed powder and add 80°C water to fully stir, and perform centrifugation, repeat 3-5 times; because fullerene is insoluble in water, it will deposit at the bottom, collect soluble matter - supernatant After drying (drying at 40° C. for 12 h), the broken ganoderma spore powder was prepared.

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Abstract

The invention discloses a method for breaking the wall of ganoderma lucidum spores. The method is to mix ganoderma spore powder and fullerene powder and perform pretreatment, so that the cluster particles in the fullerene powder are crushed into micron and / or nano particles, Enter the shell wall and interior of Ganoderma lucidum spores; then use the phase transition process of fullerene under the condition of instantaneous pressure change to expand the volume, stretch the outer wall of the spores, and realize the breaking of the spores of Ganoderma lucidum. The invention also discloses a preparation method of the broken Ganoderma lucidum spore powder and the prepared broken Ganoderma lucidum spore powder; the method retains the active ingredient content and activity of the Ganoderma lucidum spores to the greatest extent, and has a high tumor inhibition rate. The broken Ganoderma lucidum spore powder has obvious curative effect on liver injury caused by chemotherapy. The invention also discloses a preparation method of the ganoderma spore oil and the prepared ganoderma spore oil. The ganoderma spore oil is extracted from the broken ganoderma spore powder prepared in the invention, and the extraction rate is high.

Description

technical field [0001] The invention belongs to the technical field of breaking ganoderma spores, in particular to a method for breaking ganoderma spores and the prepared broken ganoderma spore powder and its application. Background technique [0002] Ganoderma lucidum is a substance rich in physiological activity, including polysaccharides, triterpenoids, nucleosides, sterols, alkaloids, furan derivatives, amino acid polypeptides, mineral elements, fatty acids, etc. Its pharmacological effects mainly include anti-tumor, immune regulation, anti-radiation, sedation, stability, cardiotonic, antihypertensive, antitussive, asthma, hypoglycemic, etc. Most of the active ingredients of Ganoderma lucidum exist in the spores of Ganoderma lucidum. Therefore, in order to make full use of the active ingredients of the spores of Ganoderma lucidum, it is necessary to break the wall of the spores of Ganoderma lucidum, so that more active substances can be released. However, the outer wall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/074B02C17/10
CPCA61K36/074A61K2236/15B02C17/10
Inventor 王春儒李慧甄明明
Owner BEIJING FUNAKANG BIOTECH CO LTD
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