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Ganoderma spore wall breaking method, wall breaking ganoderma spore powder prepared by method and application

A technology of broken-wall Ganoderma lucidum spore powder and broken-wall Ganoderma lucidum spores, which can be applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc. To achieve the effect of retaining the content and activity of active ingredients, liver damage protection, and high tumor inhibition rate

Active Publication Date: 2017-08-22
BEIJING FUNAKANG BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the wall-breaking rate of ultrafine pulverization, homogenization, ultrasonic, and high-energy ball milling impact method is relatively low, and the ultrafine pulverization method, high-energy ball milling impact method and ultrasonic wall-breaking method are not effective for active substances. The destructive power is relatively large, and it is easy to deteriorate the active substance
However, the wall-breaking process of the germination breaking method is longer, the operation is cumbersome, it is not suitable for large-scale processing, and the breaking rate is relatively low.
There are too many influencing factors in the method of biological enzyme wall breaking, among which the amount of enzyme, temperature, pH value, time, etc. will all affect the efficiency of wall breaking, so the practicability is not strong
CO 2 The supercritical wall-breaking process is carried out under ultra-high pressure, CO 2 Under critical liquid conditions, a large amount of fatty acid active substances will be released, resulting in the loss of active substances

Method used

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  • Ganoderma spore wall breaking method, wall breaking ganoderma spore powder prepared by method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1 g fullerene C 60 Mix well with 100g Ganoderma lucidum spore powder in a ball mill, then place the mixed powder in a high-pressure reactor, pressurize to 5GPa, maintain the pressure for 4h, and then quickly depressurize (0.7GPa / min) to normal pressure. After the decompression is over, take out the mixed powder and add 80°C water to fully stir, and perform centrifugation, repeat 3-5 times; because fullerene is insoluble in water, it will deposit at the bottom, collect soluble matter - supernatant After drying (drying at 40° C. for 12 h), the broken ganoderma spore powder was prepared.

Embodiment 2

[0058] 1 g fullerene C 60 Mix well with 500g Ganoderma lucidum spore powder in a ball mill, then place the mixed powder in a high-pressure reactor, pressurize to 10GPa, maintain the pressure for 5h, and then quickly depressurize (1GPa / min) to normal pressure. After the decompression is over, take out the mixed powder and add 80°C water to fully stir, and perform centrifugation, repeat 3-5 times; because fullerene is insoluble in water, it will deposit at the bottom, collect soluble matter - supernatant After drying (drying at 40° C. for 12 h), the broken ganoderma spore powder was prepared.

Embodiment 3

[0060] 1 g fullerene C 70 Mix well with 300g Ganoderma lucidum spore powder in a ball mill, then place the mixed powder in a high-pressure reactor, pressurize to 9GPa, maintain the pressure for 5h, and then quickly depressurize (0.8GPa / min) to normal pressure. After the decompression is over, take out the mixed powder and add 80°C water to fully stir, and perform centrifugation, repeat 3-5 times; because fullerene is insoluble in water, it will deposit at the bottom, collect soluble matter - supernatant After drying (drying at 40° C. for 12 h), the broken ganoderma spore powder was prepared.

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Abstract

The invention discloses a ganoderma spore wall breaking method. According to the method, ganoderma spore powder and fullerene powder are mixed and are pretreated, so that cluster particles in the fullerene powder are crushed into micrometer and / or nanometer particles to enter the shell walls and the inside of the ganoderma spores; then, the phase change process of the fullerene under the instant pressure change condition is utilized; volume expansion occurs; the spore outer walls are expanded open; the wall breaking of the ganoderma spores is realized. The invention also discloses a preparation method of the wall breaking ganoderma spore powder and the prepared wall breaking ganoderma spore powder. The method has the advantages that the active ingredient content and activity of the ganoderma spores are maintained to the maximum degree; the tumor inhibition rate is high; the prepared wall breaking ganoderma spore powder has the obvious curative effect on the liver injury due to chemotherapy. The invention also discloses a preparation method of ganoderma spore oil and the ganoderma spore oil prepared by the method. The ganoderma spore oil is obtained through being extracted from the wall breaking ganoderma spore powder obtained through preparation and the extraction rate is high.

Description

technical field [0001] The invention belongs to the technical field of breaking ganoderma spores, in particular to a method for breaking ganoderma spores and the prepared broken ganoderma spore powder and its application. Background technique [0002] Ganoderma lucidum is a substance rich in physiological activity, including polysaccharides, triterpenoids, nucleosides, sterols, alkaloids, furan derivatives, amino acid polypeptides, mineral elements, fatty acids, etc. Its pharmacological effects mainly include anti-tumor, immune regulation, anti-radiation, sedation, stability, cardiotonic, antihypertensive, antitussive, asthma, hypoglycemic, etc. Most of the active ingredients of Ganoderma lucidum exist in the spores of Ganoderma lucidum. Therefore, in order to make full use of the active ingredients of the spores of Ganoderma lucidum, it is necessary to break the wall of the spores of Ganoderma lucidum, so that more active substances can be released. However, the outer wall...

Claims

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Application Information

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IPC IPC(8): A61K36/074B02C17/10
CPCA61K36/074A61K2236/15B02C17/10
Inventor 王春儒李慧甄明明
Owner BEIJING FUNAKANG BIOTECH CO LTD
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