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Tung flower leaf petroleum ether extract and its preparation and application in the treatment of colon cancer

A petroleum ether extraction and petroleum ether technology, which is applied to the petroleum ether extract of tung flower leaves and the application fields of its preparation and treatment of colon cancer, can solve the problems of drug resistance, large toxic and side effects, tumor mutation and the like

Active Publication Date: 2020-12-18
GUANGXI UNIV OF CHINESE MEDICINE
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  • Description
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AI Technical Summary

Problems solved by technology

At present, surgery, radiotherapy, chemotherapy and the combination of the three are mainly used in the treatment of cancer, but the side effects are relatively large, and it is easy to cause tumor mutation and drug resistance.

Method used

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  • Tung flower leaf petroleum ether extract and its preparation and application in the treatment of colon cancer
  • Tung flower leaf petroleum ether extract and its preparation and application in the treatment of colon cancer
  • Tung flower leaf petroleum ether extract and its preparation and application in the treatment of colon cancer

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Embodiment Construction

[0016]1. Preparation of Tung Flower Leaf Petroleum Ether Extract (PACL)

[0017]1. Medicinal materials: Tung flower leaves were collected from Fangcheng Port, Guangxi, and were identified as the leaves of Taurus tree by Xu Mingben, Guangxi Beibu Gulf Marine Research Center.

[0018]2. Extraction and separation: dry the leaves of the paulownia tree into a coarse powder (2500g), add 25 times the amount (62.5L) of 95% ethanol and soak for 7 days; concentrate under reduced pressure to obtain the total ethanol extract of the leaves of the paulownia tree. The total extract is dissolved in pure water to form a suspension. After heating and volatilizing until there is no ethanol smell, petroleum ether is added for extraction to obtain the upper petroleum ether extract, and the upper petroleum ether extract is dried in a water bath to obtain Tung Blossom Leaf Petroleum Ether extract.

[0019]2. Study on the inhibitory effect of the extract of the petroleum ether part of Tung flower leaves on the prol...

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Abstract

The invention provides aegiceras corniculatum leaf petroleum ether extract and a preparation method thereof. The preparation method comprises adding aegiceras corniculatum leaves into ethanol, soaking the aegiceras corniculatum leaves to obtain ethanol total extract of aegiceras corniculatum leaves, volatilizing the ethanol in the ethanol total extract, adding petroleum ether into the total extract, carrying out extraction, collecting petroleum ether extract in the upper layer, carrying out water bath treatment, and carrying out drying. A research result shows that the petroleum ether extract of the aegiceras corniculatum leaves can inhibit proliferation of human colon cancer cells HT-29, SW480 and DLD-1 and significantly inhibit cloning of human colon cancer cells HT-29, SW480 and DLD-1. Therefore, the petroleum ether extract of the aegiceras corniculatum leaves has a potential application prospect in preparation of drugs for treating colon cancer and can be used for preparation of an anti-colon cancer drug. Deep development of the aegiceras corniculatum leaf petroleum ether extract can enlarge a use range of aegiceras corniculatum and provide a novel approach for cancer treatment.

Description

Technical field[0001]The invention belongs to the technical field of Aegiceras corniculatum, in particular to a petroleum ether extract of Aegiceras corniculatum leaves and its preparation and application for treating colon cancer.Background technique[0002]Aegiceras corniculatum (Aegiceras corniculatum) is a plant of the genus Aegiceras corniculatum. It is a widely distributed plant in mangrove plants. It grows on the sludge beach where the tide is ebb and flow. Current studies have shown that its chemical components mainly contain terpenoids, steroids, flavonoids, polyphenols, etc., and its pharmacological effects mainly include cytotoxicity, antifungal, antidiarrheal, and antioxidant. Due to the diversity and complexity of phytochemical components, even if it is the same plant, the efficacy of different medicinal parts and the chemical components contained in it will be very different, such as ephedra and ephedra root, ephedra mainly contains ephedrine and pseudoephedrine , And Ep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P35/00A61K127/00
CPCA61K36/185A61K2236/333A61K2236/51A61K2236/55
Inventor 罗花邓家刚侯小涛郝二伟杜正彩易湘西谢滟谭德超冯小慧
Owner GUANGXI UNIV OF CHINESE MEDICINE
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