A nano-encapsulated retinal acne gel and its preparation method

A technology of retinaldehyde acne removal and wrapping, which is applied in the direction of pharmaceutical formulas, active ingredients of aldehydes, and cosmetic preparations, etc., can solve the problems of retinaldehyde instability, strong irritation, and difficult storage, and achieve remarkable therapeutic effects, The preparation process is simple and the effect of avoiding irritation

Active Publication Date: 2021-04-13
程刚
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is no technology to directly apply retinal to acne and acne scars at present, because acne and acne scars itself is a staged process, and retinoic acid is generally used for treatment now, and its irritating strong, side effects
Due to the instability of retinal, retinal is easily oxidized to retinoic acid during application, and retinal is easily oxidized and reduced, and it is not easy to store
This also makes the application of retinal in acne and acne marks a technical problem.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 0.5 parts by weight of retinal; 1 part by weight of vitamin C; 1 part by weight of phospholipid; 20 parts by weight of polyethylene glycol-20 10 parts by weight of caprylic triglyceride or capric triglyceride; 10 parts by weight of glycerin; 5 parts by weight of water.

[0055] The preparation method of the present embodiment comprises the following process steps:

[0056] S1. Weigh each component, add glyceryl phosphate, polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin into the container, and ultrasonicate for 5 minutes until completely dissolved; heat in a water bath, and heat in a water bath The temperature is 75°C, heated for 30 minutes, and ethanol is added thereto to obtain a solution;

[0057] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 50°C. The retinal is made into powder at ...

Embodiment 2

[0060] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 5 parts by weight of retinal; 3 parts by weight of vitamin C; 20 parts by weight of phospholipids; 40 parts by weight of polyethylene glycol-20 20 parts by weight of caprylic triglyceride or capric triglyceride; 30 parts by weight of glycerin; 10 parts by weight of water.

[0061] The preparation method of the present embodiment comprises the following process steps:

[0062] S1. Weigh each component, add phospholipid (phosphoglyceride), polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin to the container, ultrasonicate for 7 minutes until completely dissolved; heat in a water bath , the temperature of the water bath heating is 85 ° C, heating for 40 minutes, and adding ethanol thereinto to obtain a solution;

[0063] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 60°C. The retinal is made ...

Embodiment 3

[0066] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 2.5 parts by weight of retinal; 2 parts by weight of vitamin C; 10 parts by weight of phospholipid; 30 parts by weight of polyethylene glycol-20 15 parts by weight of caprylic triglyceride or capric triglyceride; 20 parts by weight of glycerin; 7 parts by weight of water.

[0067] The preparation method of the present embodiment comprises the following process steps:

[0068] S1. Weigh each component, add phospholipid (phosphoglyceride), polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin to the container, ultrasonicate for 6 minutes until completely dissolved; heat in a water bath , the temperature of the water bath heating is 80 ° C, heating for 35 minutes, and adding ethanol thereinto to obtain a solution;

[0069] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 55°C. The retinal is made ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A nano-encapsulated retinal acne gel and a preparation method thereof, comprising the following raw materials by weight: 0.5-5 parts by weight of retinal; 1-3 parts by weight of vitamin C; 1-20 parts by weight of phospholipids; 20-40 parts by weight of glycol-20; 10-20 parts by weight of caprylic triglyceride or capric triglyceride; 10-30 parts by weight of glycerin; 5-10 parts by weight of water. The nano-encapsulated retinal acne gel of the present invention and the preparation method thereof have a simple production process, and the raw materials conform to the hygienic standard of cosmetics; the effect on various stages of acne is remarkable, and there are basically no uncomfortable people.

Description

technical field [0001] The invention relates to a cosmetic composition or a composition for skin diseases, in particular to a nano-encapsulated retinal acne gel and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous glands caused by multiple factors. The root cause is endocrine disorders, caused by exuberant androgen secretion. The cause of acne is also related to some pathogenic bacteria infections, and it has been confirmed that the occurrence of acne is related to the infection of Corynebacterium acnes propionii. This Corynebacterium acnes parasitizes in the pilosebaceous glands of adolescents. Through the action of lipase, it can hydrolyze triglycerides and produce more free fatty acids. These free fatty acids can cause non-specific inflammatory reactions in and around the hair follicles. When the inflammation is severe, pustules and cysts may appear. [0003] Retinoic acid drugs for external us...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61K31/4166A61K31/155A61K31/44A61K9/06A61K9/127A61K47/24A61P17/10A61K8/67A61K8/49A61K8/46A61K8/41A61K8/34A61K8/55A61K8/14A61K8/04A61Q19/10A61Q19/00
CPCA61K8/042A61K8/14A61K8/345A61K8/416A61K8/466A61K8/4946A61K8/553A61K8/671A61K9/06A61K9/127A61K31/11A61K31/155A61K31/4166A61K31/44A61Q19/00A61Q19/10
Inventor 程刚
Owner 程刚
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap