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Composition having function of enhancing learning and memory abilities and preparation method of same

A technology for enhancing memory and composition, which is applied in the fields of medical preparations containing active ingredients, drug combinations, food science, etc., can solve problems such as discomfort for long-term use, large toxic and side effects, and poor effects, and achieves easy operation, toxic and side effects. Low, enhance the effect of learning and memory

Inactive Publication Date: 2017-09-15
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, clinically for this symptom, sedative hypnosis and nervous system drugs are mainly used as auxiliary interventions, but the effect is not good; in addition, chemical drugs are mostly used at present, which have relatively large toxic and side effects, and are not suitable for long-term use.

Method used

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  • Composition having function of enhancing learning and memory abilities and preparation method of same

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Effect test

preparation example Construction

[0034] The present invention also discloses a preparation method of the above-mentioned composition for enhancing learning and memory, comprising the following steps:

[0035] Preparation of extract 1: take silkworm chrysalis by weight, crush them to obtain coarse powder, add water to soak 10-15 times the weight of silkworm chrysalis raw materials, then adjust the pH value of the solution to 1.5-2.5 with hydrochloric acid, and then adjust the pH value of the solution to 0.3-2.5 according to the weight percentage of silkworm chrysalis. Add pepsin at 0.6% and trypsin at 0.3-0.6% by weight of silkworm chrysalis, enzymatically hydrolyze at 37°C for 3-6 hours, then heat to inactivate the enzyme, filter to obtain the enzymatic hydrolyzate, and concentrate the enzymolyzate to obtain Extract one;

[0036] Preparation of extract 2: Weigh Shichangpu, polygala and ginseng by weight, add 60%-80% ethanol solution by volume percentage according to 6-10 times of the total weight of Shichangp...

experiment example 1

[0078] Experimental Example 1 Effects on Morris Water Maze Behavior

[0079] The composition powders prepared in the above examples and comparative examples were subjected to Morris water maze test.

[0080] 1. Materials

[0081] 1. Composition, the composition 1-6 that prepares by above-mentioned embodiment and comparative example;

[0082] 2. Sodium pentobarbital for injection, Shanghai Xinya Pharmaceutical Co., Ltd.;

[0083] 3. Adult Kunming mice, weighing 18-22 g, female, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences.

[0084] 2. Method

[0085] 1. Animal Grouping and Handling

[0086] The Kunming mice were randomly divided into 8 groups: 18 mice in each group, respectively blank control group, memory impairment model group, and composition 1-6 groups (2.0 g·kg -1 d -1 ). The mice in the control group and the model group were intragastrically given normal saline (20 mL·kg -1 d -1 ), the composition 1-6 groups were ...

experiment example 2

[0101] Experimental example 2 Effects on the activity and content of oxidative stress-related enzymes

[0102] The composition powders prepared in the above examples and comparative examples were subjected to oxidative stress-related enzyme activity and content determination experiments.

[0103] 1. Materials

[0104] 1. Composition, the composition 1-6 that prepares by above-mentioned embodiment and comparative example;

[0105] 2. Superoxide dismutase (superoxide dismutase, SOD) kit was purchased from Nanjing Jiancheng Company;

[0106] 3. Nitric oxide (NO) kit, purchased from Beyontian Biotechnology Company;

[0107] 4. Catalase (CAT) kit, purchased from Nanjing Jiancheng Company;

[0108] 5. Experimental animals are the same as in Experimental Example 1.

[0109] 2. Method

[0110] After the animal behavior experiment in Experimental Example 1, the brain tissue of the mouse was taken, and a 10% brain tissue homogenate was prepared with normal saline, at 4°C, 4000 r mi...

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Abstract

The invention discloses a composition having function of enhancing learning and memory abilities and a preparation method of same. The composition is prepared from, by weight, 10-30 parts of silkworm chrysalis, 2-10 parts of acorus gramineus, 2-10 parts of polygala tenuifolia, 1-5 parts of ginseng, 1-5 parts of schisandra chinensis, 1-5 parts of fructus alpiniae oxyphyllae, 1-5 parts of herba cistanche and 1-5 parts of semen cuscutae. The composition can effectively enhance learning and memory abilities, is a representative health care product of resisting senility and oxidization and enhancing immunity, and is especially suitable for elder learning and memory ability deterioration patients.

Description

technical field [0001] The invention relates to a composition, in particular to a composition for enhancing learning and memory functions, and belongs to the field of health care products. Background technique [0002] The pace of work and study in modern society is accelerating, and social pressure is increasing, which has caused many people to experience varying degrees of decline in learning and memory, which has seriously affected normal life. Today, learning and memory loss has become one of the hot clinical issues, and it is urgent to develop health products and drugs to improve or treat such diseases. At present, clinically for this symptom, sedative hypnosis and nervous system drugs are mainly used as auxiliary interventions, but the effect is not good; in addition, chemical drugs are mostly used at present, which have relatively large toxic and side effects, and are not suitable for long-term use. [0003] Traditional Chinese medicine has a long history in our coun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P25/28A23L33/105A23L33/10A61K35/64
CPCA61K36/9062A23L33/10A23L33/105A61K35/63A61K36/258A61K36/39A61K36/43A61K36/57A61K36/64A61K36/69A61K36/79A61K36/888A23V2002/00A61K2236/333A61K2236/331A61K2236/39A61K2300/00
Inventor 苑广信姜爽李盈诺潘美彤郭益宁张鑫孙月董娜王瑶刘春娜何娇田欢玲
Owner BEIHUA UNIV
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