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Mongolian medicine composition with effects of clearing heat and removing mucosal epidemic and semi-bionic optimizing extracting technology thereof

A technology of composition and Mongolian medicine, applied in the field of pharmaceuticals, can solve the problems of long extraction time, large energy consumption, ethanol, hidden safety hazards, etc., and achieve the effect of enhancing the efficacy of the medicine and reducing the loss of active ingredients

Inactive Publication Date: 2017-09-29
巴图德力根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the consumption of a large amount of energy and ethanol in this process, ethanol is a flammable and explosive solvent, and there is a great potential safety hazard in the extraction and recovery process
While the percolation method also has the above problems, the extraction time is longer

Method used

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  • Mongolian medicine composition with effects of clearing heat and removing mucosal epidemic and semi-bionic optimizing extracting technology thereof
  • Mongolian medicine composition with effects of clearing heat and removing mucosal epidemic and semi-bionic optimizing extracting technology thereof
  • Mongolian medicine composition with effects of clearing heat and removing mucosal epidemic and semi-bionic optimizing extracting technology thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0144] Preparation of reagents

[0145] Preparation of the reference solution: Accurately weigh 0.3mg of geniposide standard substance, put it into a 10mL measuring bottle, and add methanol to the scale of the measuring bottle;

[0146] Preparation of the test solution: Weigh 0.1g of the extractant of each experiment in the uniformly mixed design experiment, weigh it accurately, put it in a stoppered Erlenmeyer flask, add 25mL of methanol, weigh it, ultrasonically treat it for 20min, and let it cool , and then weighed, make up the lost weight with methanol, shake well, and filter. Precisely measure 10mL of the continued filtrate, put it in a 25mL measuring bottle, and add methanol to the mark.

[0147] systematic test

[0148] Precisely draw 10 μL of the reference solution, and inject 5 times continuously. The RSD% calculated by the peak area is 1.22, and the precision of this method is good. The results are shown in Table 7.

[0149] Table 7. Precision test of geniposide ...

Embodiment 1

[0214] The Mongolian medicinal composition for clearing away heat and eliminating stickiness has the following components in optimal parts by weight: 25 parts of Gardenia, 25 parts of Sophora flavescens, 25 parts of Chuanketong, and 15 parts of Huhuanglian. The preparation method of above-mentioned medicine comprises the following steps:

[0215] S1: Take the decoction pieces of the above four raw materials of gardenia, flavescens, akebia, and berberine, and mix them evenly;

[0216] S2: add double distilled water as decoction water, and decoct the whole components of medicinal materials together to obtain a decoction liquid;

[0217] S3: After decocting, filter the decoction obtained in S2 through a 200-mesh filter, take the filtrate, and set aside;

[0218] S4: return the filter residue obtained by filtering in S3 to S2, add decoction water, and continue decocting;

[0219] S5: combining the filtrates obtained from several decoctions in the above S3 to obtain the total fil...

Embodiment 2

[0234] On the basis of the above-mentioned examples, according to the actual industrial production conditions, this example further carried out a pilot test optimization study on this side and concluded that the best industrial production conditions of the Mongolian medicine composition are: repeating the decoction steps from S2 to S4 Once, that is, the crude drug is decocted once, and 16 times of decoction water is added, the pH value of the decoction water used is 5.00, and the decoction time is 4 hours.

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Abstract

The invention relates to a Mongolian medicine composition with effects of clearing heat and removing mucosal epidemic and a semi-bionic optimizing extracting technology thereof. The Mongolian doctor considers that the warm disease fever syndrome is a generic term of acute fever diseases caused by abnormal condition of Qisu and Xila; multiple types of Chinese and Western medicines can be used for treating the fever diseases, but the medicine usually has short therapy effect, drug resistance and toxic and side effect. The Mongolian medicine composition is prepared from 1 to 100 parts of fructus gardeniae, 1 to 100 parts of lightyellow sophora root, 1 to 100 parts of caulis clematidis armandii, and 1 to 100 parts of rhizoma picrorrhizae. The Mongolian medicine composition has the advantages that the effective components of the Mongolian medicine are extracted under the semi-bionic acid environment, and the characteristics of Mongolian medicine compounding and Mongolian doctor clinical medicine application, and the characteristic of transferring and absorbing of oral medicine in gastrointestinal tract are met; the loss of effective components is little, the effective components of iridoid glucosides, alkaloid and the like in the crude drugs are furthest extracted, the alkaloid is insoluble in water or is difficult to dissolve into water, but can be dissolved into a water solution of diluted acid to form salt, and the salt of the alkaloid is usually soluble in water, and can be easily absorbed by a human body, so that the medicine effect is enhanced.

Description

technical field [0001] The invention relates to a medicine, in particular to a Mongolian medicine composition with the curative effect of clearing away heat and eliminating stickiness and its semi-bionic optimized extraction process. Background technique [0002] Mongolian medicine believes that febrile disease fever is a general term for acute fever caused by the abnormality of Qisu and Xila, and can be caused by sticky plague infection, abnormal weather, and improper diet. Based on the pathogenesis, febrile disease fever can be divided into eight main disease stages, each of which is a specific syndrome type, namely immature heat, increasing heat, hot disease mountain beach boundary, emptiness heat, latent heat, dryness Turbidity heat, disseminated heat, old heat, etc. Generally speaking, the initial stage of febrile disease fever is immature heat, the middle stage is increasing heat, and the final stage is febrile disease mountain beach boundary. Uncooked heat develops i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61P29/00A61P31/04A61P31/12A61P1/16
CPCA61K36/489A61K36/716A61K36/744A61K36/80A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 巴图德力根韩志强
Owner 巴图德力根
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