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Process for preparing polyurethane foam dressing comprising anti-inflammatory agent

A technology of polyurethane foam and anti-inflammatory agent, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problems of incomplete dissolution of drugs, high viscosity of prepolymers, and reduced pore uniformity and other problems, to achieve the effect of excellent exudate absorption capacity and excellent foaming performance

Inactive Publication Date: 2017-10-13
DAEWOONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if a drug is added in the step of forming a polyurethane prepolymer, the resulting prepolymer exhibits too high a viscosity, and the drug cannot be sufficiently dissolved, which makes it difficult to obtain a polyurethane foam in which the drug is uniformly dispersed
Moreover, if a drug is added to the foaming solution, the drug is precipitated from the foaming solution, and it is also difficult to obtain a polyurethane foam in which the drug is uniformly dispersed
Also, adding a solubilizer for solubilizing the drug to the foaming solution will cause problems such as drug aggregation, decreased pore uniformity, etc.

Method used

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  • Process for preparing polyurethane foam dressing comprising anti-inflammatory agent
  • Process for preparing polyurethane foam dressing comprising anti-inflammatory agent
  • Process for preparing polyurethane foam dressing comprising anti-inflammatory agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation and Evaluation of Polyurethane Foam Dressing

[0033] (1) Preparation of polyurethane prepolymer

[0034] Polyether polyol (molecular weight: 4,800, VORANOL TM , The Dow Chemical Company) (39.81 g) was heated to 70° C. with stirring at 150 rpm. Thereto were added 2,4-toluene diisocyanate (9.6 g), ethylene glycol (0.24 g) and 1,4-butanediol (0.35 g). The reaction mixture was stirred for 4 hours to prepare a polyurethane prepolymer. (the amount of NCO in the polyurethane prepolymer (%)=14%)

[0035] (2) Preparation and Evaluation of Polyurethane Foam Dressing Containing Dexibuprofen

[0036] Dexibuprofen (DEX) was dissolved in ethanol (EA) at a concentration of 0.5 g / ml. 0 ml, 0.02 ml, 0.1 ml or 0.2 ml of the resulting solution were mixed with the polyurethane prepolymer prepared above, respectively. To each mixture was added a foaming solution (containing 33.4 g deionized water, 15 g glycine, and 3.34 g Poloxamer 188). The mixture was stirre...

Embodiment 2

[0045] Embodiment 2: the preparation of polyurethane foam dressing

[0046] Ibuprofen was dissolved in ethanol at a concentration of 0.5 g / ml. 1 ml of the resulting solution was mixed with the polyurethane prepolymer prepared in the same procedure as in Example 1(1). A foaming solution (containing 33.4 g of deionized water, 15 g of glycine, and 3.34 g of Poloxamer 188) was added to the mixture, and the mixture was stirred at 150 rpm for 15 seconds to form a polyurethane foam. The resulting polyurethane foam was cast onto a silicon-coated release film with a mold having a size of 10 cm x 10 cm, followed by aging for 10 minutes. The obtained polyurethane foam was dried at 70 °C for 30 min to prepare a solution containing 5 mg / cm 2 Polyurethane foam dressing of ibuprofen.

experiment example 1

[0047] Experimental example 1: Measurement of skin permeability of polyurethane foam dressing

[0048] The above prepared containing 0.1mg / cm 2 Polyurethane foam dressing of Dexibuprofen cut to size 2cm 2 , which were then applied to the skin of approximately 8-week-old hairless mice (Orient Bio Inc., Korea). Skin permeability was measured at 37°C using pH 6.8 phosphate buffer as the receiving medium. Aliquots were removed from the receiving medium at 0 minutes, 10 minutes, 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours and the concentration of dexibuprofen was determined by high performance liquid chromatography (HPLC). The results are shown in image 3 middle.

[0049] Such as image 3 Shown, the polyurethane foam dressing that the present invention makes containing Dexibuprofen shows rapid initial drug penetration, image 3 Shown to penetrate more than 40% of the drug within 30 minutes. Considering that Dexibuprofen, one of the NSAIDs, should have a high initial re...

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Abstract

The present invention provides a process for preparing a polyurethane foam dressing in which an anti-inflammatory agent is homogeneously dispersed, the process comprising obtaining a drug (i.e., anti-inflammatory agent)-containing polyurethane prepolymer using a certain dispersing agent; and reacting the drug-containing polyurethane prepolymer with a water-containing blowing solution to form a polyurethane foam and then drying the polyurethane foam.

Description

technical field [0001] The invention relates to a method for preparing polyurethane foam dressing. More specifically, the present invention relates to a method for preparing a polyurethane foam dressing in which an anti-inflammatory agent is uniformly dispersed. Background technique [0002] A wound is a skin injury where the skin is torn, cut, or opened by an external stimulus. Excessive oozing and pain due to skin cuts and injuries. Wound dressing is one of the medical products used for wound healing, which is used to protect the wound, prevent contamination, absorb exudate, prevent bleeding or loss of body fluids, etc. Various wound dressings have been developed for absorbing exudate and preventing bleeding, such as foam dressings, alginate dressings, hydrocolloid dressings, and hydrogel dressings. Also, in order to prevent infection caused by secondary pollution, silver-containing dressings are being developed. However, such wound dressings are limited in that they s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/26A61L15/44
CPCA61L15/26A61L15/42A61L15/425A61L15/44A61L2300/216A61L2300/41C08L75/04A61K31/192A61L26/0019A61L26/0066A61L26/0085A61K9/7015A61K31/167A61K47/59A61K9/7069A61K31/165
Inventor 任贤我张熙喆
Owner DAEWOONG PHARM CO LTD
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