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Menthol spray prepared from menthol submicron emulsion and application of menthol spray

A technology of menthol and submicron emulsion, which is applied in the direction of aerosol delivery, emulsion delivery, medical preparations of non-active ingredients, etc., and can solve the problems of poor water solubility of menthol

Inactive Publication Date: 2017-10-20
杭州汉光生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For this reason, the technical problem to be solved by this invention is to provide a kind of menthol spray prepared with menthol submicroemulsion, to solve the problem of poor water solubility of menthol in the prior art, and further provide the application of menthol spray

Method used

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  • Menthol spray prepared from menthol submicron emulsion and application of menthol spray
  • Menthol spray prepared from menthol submicron emulsion and application of menthol spray
  • Menthol spray prepared from menthol submicron emulsion and application of menthol spray

Examples

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Effect test

Embodiment 1

[0032] Embodiment 1 menthol cough spray

[0033] [Formulation] The formulation of the menthol cough spray described in this example includes the following components: 10 g of menthol, 30 g of refined eucalyptus oil, 10 g of soybean lecithin, and 20 ml of distilled water.

[0034] [Preparation method] Dissolve 10g of menthol in 30g of eucalyptus oil to make an oil phase, then add 10g of soybean lecithin and 20ml of distilled water, and fully emulsify through an emulsification device to obtain an oil-in-water submicron emulsion. Finally, distilled water is used to mix with the submicron emulsion, and according to the concentration of the required spray, a spray with a drug (menthol) concentration (w / v) of 1% or sprays with other concentrations is prepared.

Embodiment 2

[0035] Embodiment 2 menthol cough spray

[0036] [Formulation] The formulation of the menthol cough spray described in this example includes the following components: 10 g of menthol, 30 g of refined olive oil, 10 g of soybean lecithin, and 20 ml of distilled water.

[0037] [Preparation method] Dissolve 10g of menthol in 30g of olive oil to make an oil phase, then add 10g of soybean lecithin and 20ml of distilled water, and fully emulsify through an emulsification device to obtain an oil-in-water submicroemulsion. Finally, distilled water is used to mix with the submicron emulsion to prepare a spray with a drug (menthol) content of (w / v) 1% or other concentrations.

Embodiment 3

[0038] Embodiment 3 menthol cough spray

[0039] [Formulation] The formulation of the menthol cough spray described in this example includes the following components: menthol 10g, refined eucalyptus oil 30g, soybean lecithin 10g, vitamin E 1.2g, distilled water 20ml.

[0040][Preparation method] Dissolve 10g of menthol in 30g of eucalyptus oil to make an oil phase, then add 10g of soybean lecithin, 1.2g of vitamin E and 20ml of distilled water, and fully emulsify through an emulsification device to obtain an oil-in-water submicron emulsion. Finally, distilled water is used to mix with the submicron emulsion, and according to the concentration of the required spray, a spray with a drug (menthol) concentration (w / v) of 1% or sprays with other concentrations is prepared.

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Abstract

The invention belongs to the technical field of pharmaceutic preparations, and particularly relates to menthol spray prepared from menthol submicron emulsion and application of menthol spray. The menthol submicron emulsion is used for changing menthol with extremely low water solubility into easy-to-absorb submicron emulsion through an oil-in-water technology, so that the spray can be prepared without adding ethyl alcohol, and therefore, use of dosing through respiratory tract is realized.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a menthol spray prepared from a menthol submicroemulsion preparation and an application thereof. Background technique [0002] Menthol, also known as menthol, has a chemical name of l-1-methyl-4-isopropylcyclohexan-3-ol, which is steam distilled from the fresh stems and leaves of the Lamiaceae plant Mint (Menthahap localyx Briq), Prepared by freezing, recrystallization and other steps. The industry extracts peppermint oil and menthol from peppermint, usually by steam distillation or organic solvent extraction. The disadvantage of the former is that the extraction efficiency is low, and the problem of the latter is the residual organic solvent. The supercritical carbon dioxide extraction method can eliminate the disadvantages of the above two methods, and has gradually become the first choice for menthol extraction. [0003] Menthol has a very wid...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/12A61K31/045A61K47/44A61K47/24A61K47/22A61K47/26A61K47/36A61K47/14A61K47/38A61K47/42A61K47/12A61P11/14A61P11/00A61P11/04A61P11/02A61P37/08
Inventor 李关汉
Owner 杭州汉光生物医药科技有限公司
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