Application of honeysuckle extract in preparation of drugs for treating repeated cerebral ischemia and focal cerebral ischemia

A technology of honeysuckle extract and focal cerebral ischemia, which is applied in the field of medicine, can solve the problems of repeated cerebral ischemia and focal cerebral ischemia never seen in honeysuckle extract, and achieves the treatment of repeated cerebral ischemia, focal cerebral ischemia and the like. Effects of treatment of focal cerebral ischemia, significant economic and social benefits

Inactive Publication Date: 2017-10-20
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
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Problems solved by technology

But so far there is no public report on the preparation of honeysuckle extract to treat repeated cerebral ischemia and focal cerebral ischemia

Method used

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  • Application of honeysuckle extract in preparation of drugs for treating repeated cerebral ischemia and focal cerebral ischemia
  • Application of honeysuckle extract in preparation of drugs for treating repeated cerebral ischemia and focal cerebral ischemia
  • Application of honeysuckle extract in preparation of drugs for treating repeated cerebral ischemia and focal cerebral ischemia

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Embodiment Construction

[0007] The specific implementation of the present invention will be described in detail below in conjunction with specific circumstances.

[0008] In the specific implementation of the present invention, a kind of honeysuckle extract is used in the preparation and treatment of repeated cerebral ischemia and focal cerebral ischemia. Coarse powder, first add 10 times the weight of petroleum ether to reflux for extraction for 1 hour, degrease, and discard the petroleum ether; evaporate the residue of honeysuckle to dry petroleum ether, add 10 times the weight of honeysuckle, soak in ethanol with a mass concentration of 70% for 0.5 hours, and reflux at 80°C Extract for 1 hour, filter to obtain the first filtrate; add 70% ethanol with a mass concentration of 10 times the weight of honeysuckle to the dregs, reflux at 80°C for 1 hour, filter to obtain the second filtrate, combine the two filtrates, and recover ethanol under reduced pressure Until there is no alcohol smell, add distil...

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Abstract

The invention relates to application of honeysuckle extract in the preparation of drugs for treating repeated cerebral ischemia and focal cerebral ischemia. The honeysuckle extract can be effectively extracted from honeysuckle and used as the only active component in the preparation of the drugs for treating the repeated cerebral ischemia and the focal cerebral ischemia. A preparation method of the honeysuckle extract includes: crushing the honeysuckle into crude powder, performing ethyl ether extraction and degreasing, volatilizing the ethyl ether in dregs, soaking the dregs with 70% ethanol, performing reflux extraction, filtering, performing pressure reduction on the filtrate to recycle the ethanol until no alcohol flavor exists, dispersing with distilled water to obtain dispersion liquid containing 0.3g / mL raw drugs, using acetic acid to regulate pH, using HPD-600 or AB-8 type macroporous adsorption resin to treat the dispersion liquid, eluting with 30% ethanol, concentrating eluent, and performing freeze drying and crushing to obtain the honeysuckle extract. The application has the advantages that the honeysuckle extract can be effectively extracted from the honeysuckle and effectively used for treating the repeated cerebral ischemia and the focal cerebral ischemia, the new application and medicinal value of the honeysuckle are exploited, and evident economic and social benefits are achieved.

Description

technical field [0001] The invention relates to medicine, in particular to the application of a honeysuckle extract in the preparation of medicines for treating repeated cerebral ischemia and focal cerebral ischemia. Background technique [0002] Cerebral ischemic diseases are a group of diseases in which blood supply to the brain, cerebellum or brainstem is insufficient in one or more parts due to various reasons, thereby causing corresponding neurological symptoms. Including repeated cerebral ischemia and focal cerebral ischemia, the etiology of the formation is complex, which brings great harm to human health. Therefore, the treatment of repeated cerebral ischemia and focal cerebral ischemia is a matter of great concern to people. But although there are multiple drugs at present, their curative effect is unsatisfactory due to various reasons. Therefore, it is a technical problem that people hope to solve to develop new drugs for the treatment of repeated cerebral ischemia...

Claims

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Application Information

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IPC IPC(8): A61K36/355A61P9/10A61P25/00
CPCA61K36/355A61K2236/15A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 苗明三冯素香白明李瑞奇
Owner HENAN UNIV OF CHINESE MEDICINE
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