Iodinated lipid emulsion vascular thrombosis material, preparation method and application thereof

Abstract

The invention relates to an iodinated lipid emulsion vascular thrombosis material, a preparation method and an application thereof, and belongs to the technical field of vascular thrombosis materials used in medical appliance intervention. The iodinated lipid emulsion vascular thrombosis material includes, by mass, 20-80% of iodinated lipid emulsion, 15-75% of temperature sensitive nano-hydrogel and 0.04-3.0% of a gelator; on the basis of the mass of the iodinated lipid emulsion, the iodinated lipid emulsion includes, by mass, 50-90% of lipiodol, 0.1-0.6% of a co-surfactant and the balanced water. The vascular thrombosis material is low in viscosity and is excellent in capability of resisting blood scouring, can form firm and durable thrombosis, can be image-developed for long period, brings convenience to reexamination and diagnosis of patients at any time, has better curative effects and is safe and controllable.

Description

Technical field [0001] The invention relates to the technical field of vascular embolization materials for medical device intervention, in particular to an emulsified lipiodol vascular embolization material, and a preparation method and application thereof. Background technique [0002] Lipiodol can be deposited and retained in liver tumor tissues by injection through the hepatic artery. Therefore, it is often used clinically by interventional doctors in the field of interventional radiology, mainly used for the embolization of liver tumors. This has become The classic method of interventional embolization for liver cancer in Asian countries. When lipiodol is used for embolization, gelatin sponge is generally needed to embolize the proximal end of the blood vessel, and the lipiodol is deposited on the distal end of the blood vessel (not the peripheral blood vessel). The advantage of lipiodol as an embolic agent is that it can be used as a contrast agent and an embolic agent at th...

AI Technical Summary

Problems solved by technology

Because ordinary iodized oil is a viscous oily liquid, the viscosity increases after adding chemotherapeutic drugs, and the lumen of the 3F catheter is small. It is also very difficult to use a 1ml glass syringe for injection, with incomplete deposition and incomplete embolization; Low embolization intensity, easy recanalization of blood vessels; clinically, repeated operations are required

When using super liquefied lipiodol, although the viscosity is significantly reduced, the effect of deposition and retention in the blood vessel is also obviously worse; the deposition is incomplete, the embolization strength is low, and there are likely to be residual cancer cells, and the lipiodol is easily absorbed by the blood. The blood flow scours the metabolism, and the tumor blood vessels are easy to recanalize, which leads to the need for repeated embolization treatments for patients, and the long-term curative effect needs to be improved; moreover, almost all super liquefied lipiodol is imported, expensive, and the market is in short supply, so it is not easy to buy

There is no embolic material with low viscosity and good embolic effect in the prior art

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