Preparation method of anion resin adsorbent for bilirubin

An anion resin and adsorbent technology, applied in the field of bilirubin anion resin adsorbent and its preparation, can solve the problems of inability to expose, affect bonds and efficiency, etc.

Active Publication Date: 2017-10-20
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bilirubin adsorption resins usually use styrene resin as the matrix, because styrene has only one benzene ring, most of the benzene rings are embedded in the polymer and cannot be exposed, and only a few reactive sites are in contact with the outside world, which affects the keys and efficiency

Method used

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  • Preparation method of anion resin adsorbent for bilirubin
  • Preparation method of anion resin adsorbent for bilirubin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of porous biphenyl resin

[0029] Prepare 1 L of an aqueous solution containing 10 g / L of polyvinyl alcohol and 20 g / L of gelatin as the aqueous phase solution of the reaction system for preparing biphenyl porous polymer microspheres by suspension polymerization. Dissolve 120mg of benzoyl peroxide in a mixed solution containing 12mL of 4-vinylbiphenyl, 3mL of divinylbenzene and 18mL of n-heptane, add the oily mixed solution to 60mL of aqueous solution, and the resulting oil-water two-phase separation The mixed system of layers was stirred at room temperature at a mechanical stirring speed of 300rpm for 4h, then the temperature was raised to 80°C, and the polymerization reaction was carried out for 24h. Dry it under vacuum for 12 hours before use.

[0030] Chloromethyl resin preparation

[0031] Slowly add 40mL of thionyl chloride into 40mL of methylal, stir for 1h, mix the resulting solution with 20g of biphenyl resin, soak at 25°C for 2h. Add 6g ZnCl...

Embodiment 2

[0036] (1) Preparation of porous biphenyl resin

[0037] Prepare 1L of aqueous solution containing polyvinyl alcohol (PVA) as 8g / L and gelatin as 14g / L as the aqueous phase solution of the biphenyl porous polymer microsphere reaction system prepared by suspension polymerization. 120mg of benzoyl peroxide (BPO) was dissolved in a mixed solution containing 12mL of 4-vinylbiphenyl, 3mL of divinylbenzene and 20mL of n-heptane, and the oily mixed solution was added to 60mL of aqueous solution to obtain oil-water The two-phase layered mixed system was stirred at room temperature at a mechanical stirring speed of 300rpm for 4h, then the temperature was raised to 80°C, and the polymerization reaction was carried out for 24h. Dry it under vacuum for 12 hours before use.

[0038] Chloromethyl resin preparation

[0039] Slowly add 40mL of thionyl chloride into 40mL of methylal, stir for 1h, mix the resulting solution with 20g of biphenyl resin, soak at 25°C for 2h. Start the stirrer a...

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Abstract

The invention relates to a preparation method of an anion resin adsorbent for bilirubin. The preparation method comprises specific steps as follows: porous biphenyl resin with diameter being 100 mu m-1000 mu m is prepared with a suspension polymerization method by adopting 4-vinylbiphenyl as a functional monomer and divinylbenzene as a cross-linking agent, then merrifield resin is prepared through a chloromethylation reaction, finally, amine compounds react with merrifield resin, and anion polymer resin is obtained. According to the preparation method, biphenyl resin is prepared from 4-vinylbiphenyl as the functional monomer, and the number of benzene rings and reactable sites are increased. The prepared bilirubin absorbing resin has highly efficient adsorbing or removing effect on bilirubin in a solution or plasma.

Description

technical field [0001] The invention belongs to the field of blood purification, and relates to a bilirubin anion resin adsorbent and a preparation method and application thereof. Background technique [0002] Bilirubin is a metabolite of hemoglobin in red blood cells, and is one of the important indicators of whether the human liver function is normal. The removal of high levels of bilirubin in blood is one of the focuses that the medical community has been paying attention to. The preparation of medical adsorption materials for removing bilirubin in blood is the key technology of this focus. [0003] Polymer microsphere resin materials have been used in blood purification therapy due to their good removal effect on harmful components in blood such as bilirubin. Cited from literature: S.R.Ash, T.A.Sullivan, D.J.Carr; Therapeutic Apheresis and Dialysis; 2006,.10, 145:153 Sorbent Suspensions vs. Sorbent Columns for Extracorporeal Detoxification in Hepatic Failure; P.Krisper,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30C08F212/32C08F212/36C08F2/20C08F8/24C08F8/32
CPCB01J20/26C08F8/24C08F8/32C08F212/32C08F212/36C08F2/20
Inventor 邹汉法董靖欧俊杰
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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