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Application of tetrodotoxin in preparation of pharmaceutical composition for treating prostatitis symptom, pharmaceutical composition and preparation method

A technology of tetrodotoxin and composition, which is applied in the new health care and drug treatment application field of tetrodotoxin, can solve the problems of patient suffering, affect the quality of life of patients, etc. Effect

Inactive Publication Date: 2017-11-03
东新皓特(北京)生化科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Seriously affect the quality of life of patients and cause great pain to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A pharmaceutical composition for the treatment of prostate disease, the pharmaceutical composition is mainly prepared from raw materials of the following quality through processing:

[0052] Tetrodotoxin 1mg; Hippocampus 5g;

[0053] Astragalus 20g; Guizhi 5g;

[0054] Cordyceps 4g; Yam 10g;

[0055] Codonopsis 20g; Polygonum cuspidatum 15g;

[0056] Plantago Seed 10g; Atractylodes Rhizome 10g;

[0057] Atractylodes 5g; Dandelion 10g.

[0058] Preparation:

[0059] a: Weigh the raw materials of Astragalus, Guizhi, Yam, Polygonum cuspidatum, Semen Plantaginis, Atractylodes macrocephala, Codonopsis pilosula and Dandelion, add water to decoct 3 times, and add water for the first time is 10% of the total weight of the eight raw materials. times, decocting for 3 hours; adding water for the second time is 5 times the total weight of Bawei raw materials, and adding water for the third time is 3 times the total weight of Bawei raw materials, decocting for 1 hour; combine t...

Embodiment 2

[0062] A pharmaceutical composition for the treatment of prostate disease, the pharmaceutical composition is mainly prepared from raw materials of the following quality through processing:

[0063] Tetrodotoxin 0.8mg; Hippocampus 10g;

[0064] Astragalus 40g; Guizhi 10g;

[0065] Cordyceps 6g; Yam 20g;

[0066] Codonopsis 30g; Polygonum cuspidatum 20g;

[0067] Plantago seed 20g; Atractylodes macrocephala 20g;

[0068] Atractylodes 10g; Dandelion 20g.

[0069] The preparation method was prepared according to the method of Example 1.

[0070] It should be noted that the replacement of the pharmaceutical composition in this example with an equivalent amount of tetrodotoxin can also be implemented to achieve the expected effect, that is, only tetrodotoxin is needed when making the pharmaceutical composition, and no other traditional Chinese medicine raw materials are added. Example 3:

Embodiment 3

[0071] A pharmaceutical composition for the treatment of prostate disease, the pharmaceutical composition is mainly prepared from raw materials of the following quality through processing:

[0072] Tetrodotoxin 0.5mg; Hippocampus 8g;

[0073] Astragalus 30g; Guizhi 8g;

[0074] Cordyceps 5g; Yam 15g;

[0075] Codonopsis 25g; Polygonum cuspidatum 18g;

[0076] Plantago Seed 15g; Atractylodes Rhizome 15g;

[0077] Cangzhu 8g; Dandelion 15g.

[0078] The preparation method was prepared according to the method of Example 1.

[0079] It should be noted that the replacement of the pharmaceutical composition in this example with an equivalent amount of tetrodotoxin can also be implemented to achieve the expected effect, that is, only tetrodotoxin is needed when making the pharmaceutical composition, and no other traditional Chinese medicine raw materials are added. Embodiment 4:

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PUM

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Abstract

The invention discloses application of tetrodotoxin in preparation of a pharmaceutical composition for treating prostatitis symptom. The pharmaceutical composition for treating prostatitis symptom comprises tetrodotoxin and / or a derivate thereof and is composed of the following raw materials by mass: tetrodotoxin, sea horse, astragalus membranaceus, cassia twig, cordyceps sinensis, dioscorea opposite, codonopsis pilosula, polygonum cuspidatum, semen plantaginis, rhizoma atractylodis macrocephalae, rhizoma atractylodis and dandelion. The pharmaceutical composition has the vasodilatation effect, and is capable of clearing away harmful metabolites and heavy metals, improving vascular permeability, relieving hyperaemia and swell of prostate tissue, speeding up metabolism, speeding up the excreting of toxic metabolites, removing suppurative emboli in prostate, regulating pH of prostatic fluid, retracting glandulae prostata muliebris, repairing injured tissues and denatured neurons, activating cells, improving immunity of glandulae prostata muliebris, and eliminating focus, thus completely treating prostatitis as well as achieving extremely low recurrence rate.

Description

technical field [0001] The present invention relates to the new health care and drug treatment application of tetrodotoxin, in particular to the application of tetrodotoxin in the preparation of pharmaceutical composition for treating prostate disease, pharmaceutical composition and preparation method. Background technique [0002] Tetrodotoxin (TTX), also known as Spheroidin, is a marine toxin found in puffer fish, salamanders, spotted-footed toads and other animals. Toxins mainly exist in the gonads, liver, spleen, eyes, skin, blood and other parts of puffer fish. Tetrodotoxin is isolated from the ovary or liver of puffer fish. It is a non-protein small molecular compound. [0003] In 1909, Yoshisumi Tahara of Japan extracted a crude product toxin from the eggs of Dolphinus and named it tetrodotoxin (TTX). TTX crystal was obtained in 1950, its molecular structure was elucidated in 1964, and it was artificially synthesized in 1972. Over the past decades, foreign scholar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/529A61K36/8945A61P13/08A61K35/60
CPCA61K31/529A61K35/60A61K36/068A61K36/284A61K36/288A61K36/344A61K36/481A61K36/54A61K36/68A61K36/704A61K36/8945A61K2300/00
Inventor 刘皓刘延东
Owner 东新皓特(北京)生化科技有限公司
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