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Ferrous bisglycinate iron-supplement preparation and preparing method thereof

A technology of ferrous glycinate and iron supplementation, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, metabolic diseases, etc., can solve the problems of poor iron odor masking effect and unsatisfactory effect of iron supplementation, etc., to avoid gastrointestinal problems. Stimulation, iron-enhancing effect, low-dose effect

Active Publication Date: 2017-11-07
海而思(郑州)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Patent CN101129351A discloses an iron supplement composition, which is prepared from ferrous glycinate, antioxidants and pharmaceutical carriers, although such an iron supplement as in this patent has a significant impact on the taste of the preparation and iron supplementation through component selection and process optimization. The effect has been improved, but the effect of iron supplementation is still unsatisfactory and needs to be further improved, and the masking effect of the iron smell is poor

Method used

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  • Ferrous bisglycinate iron-supplement preparation and preparing method thereof
  • Ferrous bisglycinate iron-supplement preparation and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1: Preparation of ferrous glycinate iron preparation of the present invention

[0038] Add 0.9g of α-cyclodextrin and 0.1g of ferrous glycinate into the ball mill, add stainless steel grinding balls, turn on the power to run the ball mill, and obtain ferrous glycinate clathrate after grinding for 2 hours.

[0039] White granulated sugar 47.5g, glucose 23g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g (the jujube is decocted, beaten and filtered, then spray-dried), citric acid 5g, steviol glycoside 0.1g Add the above-mentioned clathrate into the mixer and mix evenly. After boiling with a boiling granulator, spray an appropriate amount of water as a binder for boiling granulation. Dry at 60°C for 90 minutes until the water content is below 2%. Iron preparations.

Embodiment 2

[0040] Embodiment 2: Preparation of ferrous glycinate iron preparation of the present invention

[0041] Add 2.5g of β-cyclodextrin, 3g of purified water, and 0.2g of ferrous glycinate into a round bottom flask, heat to reflux (reflux temperature is the boiling point of water, ie 100°C) for 60 minutes, pour into a beaker, and place in the refrigerator Cool down to below 4°C, filter with a suction filter bottle, wash once with water or 95% ethanol, and dry after drying (the drying temperature is controlled between 40 and 70 degrees, and the particle moisture is controlled between 0.5 and 3.0%) ), to obtain ferrous glycinate clathrate.

[0042] White granulated sugar 47.5g, glucose 21.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g (the jujube is decocted and filtered, then spray-dried), citric acid 5g, steviol glycoside 0.1g Add the above-mentioned clathrate into a tank mixer, add an appropriate amount of 95% ethanol as a binder to make a soft ma...

Embodiment 3

[0043] Embodiment 3: Preparation of ferrous glycinate iron preparation of the present invention

[0044]Add 0.9g of β-cyclodextrin and 0.1g of ferrous glycinate into the ball mill, add stainless steel grinding balls, turn on the power to run the ball mill, and obtain ferrous glycinate clathrate after grinding for 2 hours.

[0045] White granulated sugar 47.5g, glucose 23g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g (the jujube is decocted, beaten and filtered, then spray-dried), citric acid 5g, steviol glycoside 0.1g Add the above-mentioned clathrate into the mixer and mix evenly. After boiling with a boiling granulator, spray an appropriate amount of water as a binder for boiling granulation. Dry at 60°C for 90 minutes until the water content is below 2%. Iron preparations.

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Abstract

The invention relates to the technical field of medicine preparing, and discloses a ferrous bisglycinate iron-supplement preparation and a preparing method thereof. The iron-supplement preparation comprises ferrous bisglycinate, vitamin C, jujube powder, fruit powder, maltodextrin, white granulated sugar, glucose, citric acid, stevioside and cyclodextrin, or ferrous bisglycinate, vitamin C, the jujube powder, the fruit powder, maltodextrin, the white granulated sugar, glucose, citric acid, stevioside and gelatin. According to the ferrous bisglycinate iron-supplement preparation and the preparing method thereof, based on clathration of cyclodextrin or gelatin to ferrous bisglycinate, multiple appropriate components are additionally added, the novel ferrous bisglycinate iron-supplement preparation is prepared, the iron sheet taste can be sheltered, the stimulus to the intestines and stomach is avoided, most surprisingly, the iron-supplement effect can be further remarkably improved, and with a small dose and a short time, an iron-deficiency anemia patient restores a normal hemoglobin degree.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a preparation for supplementing iron with ferrous glycinate and a preparation method thereof. Background technique [0002] Iron is one of the important elements of human body composition. Iron deficiency anemia is a common disease. According to relevant reports, about 20% of the people in the country belong to iron deficiency anemia in different degrees, especially pregnant women, children and the elderly. High incidence group of iron anemia. There are many kinds of iron supplement preparations, ranging from inorganic iron, organic iron to biological iron supplements, amino acid chelated iron, and iron supplement preparations are constantly developing. However, almost all iron supplement preparations are poor in palatability, have a strong iron smell, are highly irritating to the gastrointestinal tract, and are prone to vomiting, heartburn, constipation and black s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K47/69A61K47/64A61P7/06A61P3/02
CPCA61K33/26
Inventor 秦和平
Owner 海而思(郑州)科技有限公司
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