Application of Vine Tea Extract in Preparation of Farnesoid X Receptor Agonist
A technology of rattan tea extract and extract liquid, applied in the application field of medicine, can solve the problems of no report on the application of rattan tea extract and the like
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Embodiment 1
[0049] Example 1 Preparation of vine tea extract AG
[0050] Take the dried vine tea leaves, extract with 55% ethanol aqueous solution as solvent, the ratio of solid to liquid is 1:10, reflux extraction for 3 times, extract for 1 hour each time, combine the extracts, concentrate under reduced pressure, and dry to get vine tea extract AG .
Embodiment 2
[0051] Example 2 Preparation of vine tea extracts AG-A1, AG-A2, AG-A3
[0052] The rattan tea extract AG prepared in Example 1 was dissolved in hot water, and it was prepared into an aqueous solution with a concentration of 20 mg / mL, with a sample loading volume of 300 mL, purified by LX-2000 macroporous resin column chromatography, and the diameter of the macroporous resin column was 8cm, the column volume is 3.5L, water is used as mobile phase A, ethanol is used as mobile phase B, the flow rate of gradient elution is 3BV / h, and the gradient elution is carried out according to the following procedure: first use A:B volume ratio of 100% : 0% mobile phase to elute 3BV, collect the eluate, concentrate and dry to obtain vine tea extract AG-A1, then use A:B volume ratio of 50%:50% mobile phase to elute 4BV, collect and elute solution, concentrated under reduced pressure and dried to obtain vine tea extract AG-A2, and then use A:B volume ratio of 10%:90% mobile phase to elute 4BV...
Embodiment 3
[0053] Example 3 Preparation of vine tea extracts AG-B1 and AG-B2
[0054] Dissolve the vine tea extract AG prepared in Example 1 with hot water, prepare an aqueous solution with a concentration of 20 mg / mL, add 2 times the volume of ethyl acetate to extract 3 times, combine the ethyl acetate layers, concentrate under reduced pressure, and dry , to obtain vine tea extract AG-B1; combine the aqueous layers, concentrate under reduced pressure, and dry to obtain vine tea extract AG-B2.
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