Long-acting kanamycin sulfate injection for veterinary use and preparation method of injection

A technology of kanamycin sulfate and kanamycin monosulfate, which is applied in the field of veterinary long-acting kanamycin sulfate injection and its preparation, can solve the problems of short drug effect and inconvenient clinical operation, and achieve long-term action Prolonging, reducing toxic and side effects, and stabilizing blood drug concentration

Inactive Publication Date: 2017-12-01
浙江大飞龙动物保健品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The number of affected pigs in large-scale breeding is often hundreds or even thousands. The dosage of Kanamycin Sulfate Injection recorded in the Veterinary Pharmacopoeia is twice a day, which is inconvenient for clinical operation and has short efficacy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A long-acting kanamycin sulfate injection for veterinary use, containing per 1000L: 50kg of kanamycin monosulfate, 40g of disodium edetate, 1kg of sodium bisulfite, 50kg of polyvinylpyrrolidone, and 300kg of polyethylene glycol 50kg, the balance is water for injection.

[0023] A preparation process for animal long-acting kanamycin sulfate injection, its preparation method:

[0024] (1) Add a total of 40% freshly prepared water for injection into the 100,000-grade district concentration tank, control the water temperature at 60-55°C, add 1kg of sodium bisulfite, 50g of disodium edetate and carboxymonosulfate while stirring Namycin 50kg, stirred for 10 minutes to dissolve, then added polyvinylpyrrolidone 50kg and polyethylene glycol 300 50kg, stirred for 5 minutes;

[0025] (2) Filter the liquid medicine in the concentrated preparation tank through a microporous filter (0.45um) to the thin preparation tank in the 10,000-grade area; add freshly prepared water for injecti...

Embodiment 2

[0029] A veterinary drug long-acting kanamycin sulfate injection, containing per 1000L: Kanamycin monosulfate 100kg, edetate disodium 50g, sodium bisulfite 2kg, polyvinylpyrrolidone 100kg, polyethylene glycol 300 100kg , and the balance is water for injection.

[0030] A preparation process for animal long-acting kanamycin sulfate injection, its preparation method:

[0031] (1) Add a total of 40% freshly prepared water for injection into the 100,000-grade district concentration tank, control the water temperature at 60-55°C, add 2kg of sodium bisulfite, 50g of disodium edetate and carboxymonosulfate while stirring Namycin 100kg, stirred for 10 minutes to dissolve, then added polyvinylpyrrolidone 100kg and polyethylene glycol 300 100kg, stirred for 5 minutes;

[0032] (2) Filter the liquid medicine in the concentrated preparation tank through a microporous filter (0.45um) to the thin preparation tank in the 10,000-grade area; add freshly prepared water for injection to 1000L, ...

Embodiment 3

[0036] A long-acting kanamycin sulfate injection for veterinary use, containing per 1000L: 250kg of kanamycin monosulfate, 50g of disodium edetate, 5kg of sodium bisulfite, 150kg of polyvinylpyrrolidone, and 300kg of polyethylene glycol 150kg, the balance is water for injection.

[0037] A preparation process for animal long-acting kanamycin sulfate injection, its preparation method:

[0038] (1) Add a total of 40% of freshly prepared water for injection into the 100,000-grade district concentration tank, control the water temperature at 60-55°C, add 5kg of sodium bisulfite, 50g of disodium edetate and carboxymonosulfate while stirring Namycin 250kg, stirred for 10 minutes to dissolve, then added polyvinylpyrrolidone 150kg and polyethylene glycol 300 150kg, stirred for 5 minutes;

[0039] (2) Filter the liquid medicine in the concentrated preparation tank through a microporous filter (0.45um) to the thin preparation tank in the 10,000-grade area; add freshly prepared water fo...

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PUM

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Abstract

The invention discloses a long-acting kanamycin sulfate injection for veterinary use and a preparation method of the injection, and belongs to the technical field of preparations for veterinary use. Each 1000L of the injection consists of 50-250kg of kanamycin sulfate, 40-60g of edetate disodium, 1-5kg of sodium hydrogen sulfite, 50-150kg of polyvinylpyrrolidone, 50-150kg of polyethylene glycol 300 and the balance of injection water. The long-acting kanamycin sulfate injection for veterinary use prepared by the invention, in comparison a national-standard kanamycin sulfate injection, can double an effective drug peak concentration retention time, so that efficacy of antipyretics is prolonged and clinical operations are reduced; and the injection is more conducive to rapid recovery of diseased pigs.

Description

technical field [0001] The invention belongs to the technical field of veterinary preparations, in particular to a veterinary long-acting kanamycin sulfate injection and a preparation method thereof. Background technique [0002] In recent years, with the development of scale and intensification of the pig industry, the breeding density is increasing, and various diseases, especially the respiratory diseases of livestock and poultry, are increasing day by day. Antibacterial drugs are frequently used clinically, and bacteria are prone to drug resistance. Therefore, research and development of long-acting drug preparations for controlling the respiratory tract is one of the important ways to reduce feeding costs, improve economic efficiency, and reduce drug residues. [0003] As we all know, when pigs get sick, their body temperature often rises, their feed intake drops sharply, and the use of drug mixing or drinking water often fails to achieve the desired effect. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/32A61K47/10A61K31/7036A61P31/04
CPCA61K9/0019A61K9/0002A61K9/08A61K31/7036A61K47/10A61K47/32
Inventor 沈建军舒鑫标唐群霞彭俊平宋占学施伟领胡永明
Owner 浙江大飞龙动物保健品股份有限公司
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