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Bergenia crassifolia extract and extracting method and medical application in oral diseases

A technology of cabbage and an extraction method, which are applied in the directions of medical preparations containing active ingredients, oral care, medical science, etc., can solve problems such as unreported cabbage

Inactive Publication Date: 2017-12-15
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of rock cabbage in the prevention and treatment of oral diseases, etc.

Method used

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  • Bergenia crassifolia extract and extracting method and medical application in oral diseases
  • Bergenia crassifolia extract and extracting method and medical application in oral diseases
  • Bergenia crassifolia extract and extracting method and medical application in oral diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Aqueous extract of rock cabbage and preparation of the extract

[0023] The water extract of rock cabbage and the preparation of the extract are to take dried rock cabbage and crush it, add 500g of rock cabbage powder to 5000mL of pure water according to the ratio of 1g of rock cabbage powder to 10ml of water, soak 2 hours, reflux extraction at 100°C for 2 hours, filter and centrifuge, collect the filtrate, repeat the above operation twice for the residue, combine the filtrate three times, concentrate under reduced pressure at 40°C to obtain the extract, add an equal volume of petroleum ether, chloroform, and ethyl acetate in sequence Ester and n-butanol were systematically extracted to obtain petroleum ether extract, chloroform extract, ethyl acetate extract and n-butanol extract respectively. The remaining stock solution after extraction is the water extract. Evaporate to dryness in a constant temperature water bath at 50°C to obtain the water extract and its extract...

Embodiment 2

[0025] 70% ethanol extract of rock cabbage and its preparation

[0026] The preparation of the 70% ethanol extract of rock cabbage is to take the dried rock cabbage and grind it, add 5000mL 70% ethanol to 500g rock cabbage powder according to the ratio of 1g rock cabbage powder plus 10ml 70% ethanol , soak for 2 hours, reflux extraction at 100°C for 2 hours, filter and centrifuge, collect the filtrate, repeat the above operation twice for the residue, combine the filtrate three times, concentrate under reduced pressure at 40°C to obtain the extract, and add an equal volume of petroleum ether, chloroform, Ethyl acetate and n-butanol were systematically extracted to obtain petroleum ether extract, chloroform extract, ethyl acetate extract and n-butanol extract respectively. The remaining stock solution after extraction is to obtain a 70% ethanol extract. Evaporate in a constant temperature water bath at 50°C to obtain 70% ethanol extract and extract. Dissolve the obtained extr...

Embodiment 3

[0028] 95% ethanol extract of rock cabbage and preparation of the extract

[0029]The preparation of the 95% ethanol extract of rock cabbage is to take the dried rock cabbage and grind it, add 5000mL 95% ethanol to 500g rock cabbage powder according to the ratio of 1g rock cabbage powder plus 10ml 95% ethanol , soak for 2 hours, reflux extraction at 100°C for 2 hours, filter and centrifuge, collect the filtrate, repeat the above operation twice for the residue, combine the filtrate three times, concentrate under reduced pressure at 40°C to obtain the extract, and add an equal volume of petroleum ether, chloroform, Ethyl acetate and n-butanol were systematically extracted to obtain petroleum ether extract, chloroform extract, ethyl acetate extract and n-butanol extract respectively. The remaining stock solution after extraction is 95% ethanol extract. Evaporate in a constant temperature water bath at 50°C to obtain 95% ethanol extract and its extract. Each of the obtained ext...

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PUM

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Abstract

The invention provides a bergenia crassifolia extract and an extracting method and medical application in oral diseases. Through a resazurin dyeing method and an XTT method, the extract of bergenia crassifolia is subjected to bacteriostatic activity and inhibitory biological film activity study, the extract of bergenia crassifolia has an obvious inhibitory effect on streptococcus mutans, streptococcus sanguis, streptococcus salivarius, lactobacillus acidophilus, porphyromonas gingivalis, fusobacterium nucleatum, actinobacillus actinomycetemcomitan and biological film of the fungi, has a better inhibitory effect on streptococcus mutans, porphyromonas gingivalis and the biological film of the fungi and can be used for preparing daily necessities and medicine for preventing and treating the oral diseases.

Description

technical field [0001] The invention provides a rock cabbage extract and an extraction method. The invention further discloses the medical use of the extract in oral diseases, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] The occurrence of oral diseases is mainly caused by a bacterial infectious disease caused by the loss of balance of microorganisms in the oral environment. burden. Common oral diseases mainly include dental caries, periodontitis, etc. The main pathogenic bacteria include Streptococcus mutans, Streptococcus sanguis, Streptococcus salivarius, Lactobacillus acidophilus, Porphyromonas gingivalis, Fusobacterium nucleatum and Actinobacillus, etc. According to the survey, the caries rate of deciduous teeth of children in my country is as high as 67.0%, the rate of caries of permanent teeth in middle-aged people is 59.9%, and the rate of edentulous people in the elderly group is 6.9%. General poor healt...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/02A61K8/9789A61Q11/00
CPCA61K8/97A61K36/185A61K2236/331A61K2236/333A61K2236/39A61K2236/50A61K2236/51A61Q11/00
Inventor 李玉新刘玉翠鲍永利许艳杰易静雯
Owner NORTHEAST NORMAL UNIVERSITY
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