A method for the establishment of a systemic bone injury model based on local irradiation and the analysis of its pathological mechanism

Abstract

The invention discloses a method for establishing a systemic bone injury model and pathological mechanism analysis based on partial irradiation. Local irradiation of the knee joint is used to avoid high mortality and complicated pathological mechanisms of animals after whole-body irradiation; Irradiation damages intestines, kidneys, gonads and other organs closely related to bone metabolism; through single radiation damage to bone tissues and organs, the pathological mechanism of systemic radiation bone injury caused by local irradiation is effectively elucidated; it is helpful for the discovery of the pathological mechanism of radiation bone injury Early preventive intervention for clinical radiotherapy patients and as a model for new drug development and drug efficacy testing.

Description

technical field [0001] The invention relates to a systemic bone injury model method and pathological mechanism application based on local irradiation. Background technique [0002] Radiation bone injuries (Radiation bone injuries) are a common type of radiation injury in people exposed to clinical radiation therapy for malignant tumors. With the increase in the incidence of malignant tumors and the wide application of radiotherapy in the treatment of malignant tumors, the incidence of radiation-induced bone injury is increasing. As reported by Ogino I et al., the incidence of necrotic fractures in patients undergoing radiotherapy for uterine cancer is as high as 17%. Once radiation fracture or osteonecrosis occurs, only palliative conservative treatment or surgical resection of sequestrum for bone grafting can be used clinically, and the effect is not satisfactory. Current models of radiation-induced bone injury are based on whole-body irradiation or partial irradiation of ...

AI Technical Summary

Problems solved by technology

Whole body irradiation involves all organs and tissues. Although it can achieve rapid bone damage, the mortality rate of animals is high, and the etiology of bone damage is complex, not a single radiation factor, and it is significantly different from clinical radiotherapy methods.

Local irradiation is generally abdominal irradiation. Due to the small size of animals, it is difficult to achieve effective protection like clinical patients. The abdominal intestines, kidneys and gonads are inevitably involved. The intestines, kidneys and gonads are closely related to bone metabolism. Therefore, the abdominal irradiation model cannot well reflect the pathogenesis of bone mass decline in clinical radiotherapy patients, especially those radiation fractures that occur in non-irradiated areas 5-10 years after radiotherapy