Preparation method of creatine phosphate sodium

Abstract

The invention discloses a preparation method of creatine phosphate sodium, wherein creatinine acyl chloride, as a raw material, is reacted with NaOH to produce the creatine phosphate sodium. The preparation method includes the steps of: 1) raw material reaction; 2) preparation of a crude product of the creatine phosphate sodium; 3) three-time recrystallization; and 4) preparation of a final product of the creatine phosphate sodium. The preparation method is simple, has high operability, is low in cost and is high in yield. The creatine phosphate sodium is high in crystalline degree and has complete crystal form, uniform particle size distribution and high purity. The product has stable performance and significant pharmacologic effect in clinical application, is suitable for industrial production, and has social benefit for reducing price of existing myocardial protection medicines.

Description

technical field [0001] The invention relates to the technical field of preparation of cardiovascular drugs, in particular to a preparation method of creatine phosphate sodium. Background technique [0002] World epidemiological trends show that cardiovascular disease is one of the main diseases that threaten human health today, and its morbidity and mortality have surpassed malignant tumors, ranking first. With the rapid development of social economy, this type of diseases has increased significantly in large and medium-sized cities in my country. Cardiovascular disease is a slow-developing, sudden-onset, and highly dangerous disease that is often subject to many limitations and unpredictable factors in clinical treatment and medication. The current medical community believes that early control of the development of cardiovascular disease is the only effective prevention and treatment method. Creatine Sodium Phosphate is a natural active substance in the human body, which ...

AI Technical Summary

Problems solved by technology

At present, creatine phosphate sodium has two kinds of imported drugs and domestic drugs. The price of imported drugs is relatively high. Although the average price of domestic drugs is about 24% lower than that of imported drugs, they are still high value-added drugs.

Moreover, domestic creatine phosphate sodium products have problems such as small particle size and poor crystal habit. There are serious hardening phenomena in the production process, and the production operation is very difficult, which is not conducive to large-scale production. The product price cannot meet the market demand of ordinary consumers.