Standard product for detection of clinical drug-resistant genes in intestinal cancer and application thereof

A drug-resistant gene and standard product technology, which is applied in the determination/testing of microorganisms, DNA/RNA fragments, recombinant DNA technology, etc., can solve the problems of lack of diversity and the existence of test results, and achieve the effect of accurate guidance

Pending Publication Date: 2017-12-29
GENE CRAB BIOTECH CO +1
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Problems solved by technology

[0005] The main purpose of the present invention is to provide a standard product for clinical drug resistance gene detection of intestinal cancer and its application, so...

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  • Standard product for detection of clinical drug-resistant genes in intestinal cancer and application thereof
  • Standard product for detection of clinical drug-resistant genes in intestinal cancer and application thereof
  • Standard product for detection of clinical drug-resistant genes in intestinal cancer and application thereof

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Embodiment Construction

[0029] It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present invention will be described in detail below in conjunction with examples.

[0030] As mentioned in the background technology, the detection results of the detection kits for gene mutations related to cancer in the prior art are diverse and lack clinical guiding significance, and there is currently no effective solution. In a typical embodiment of the present application, a standard product for clinical drug resistance gene detection of colorectal cancer is provided, the standard product includes: a minimum detection limit reference product, the minimum detection limit reference product includes at least two different levels of variation The frequency DNA mixture, the DNA mixture of each level of variation frequency includes the mutation sites shown in Table 1 below:

[0031] Table 1:

[0032] ...

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Abstract

The invention provides a standard product for detection of clinical drug-resistant genes in intestinal cancer and application thereof. The standard product comprises a minimum detection limit reference product, the minimum detection limit reference product at least comprises a DNA mixture of two different levels of mutation frequencies, the DNA mixture of each level of mutation frequency comprises mutation sites shown in the following table 1. By using a DNA mixture containing multiple gene mutation sites related to the mutation of the intestinal cancer as a minimum detection limit reference product, and the standard product comprises the DNA mixture of at least two levels of mutation frequencies, which can be able to detect whether mutations can be detected and the frequencies of mutation can be detected or not when kits from different manufactures are used for corresponding gene mutation, thus the accuracy and reliability of detection results of each kit can be verified, and thereby relatively accurate guidance for clinical medication can be provided.

Description

technical field [0001] The invention relates to the field of intestinal cancer detection kits, in particular to a standard product for clinical drug resistance gene detection of intestinal cancer and its application. Background technique [0002] In recent years, targeted therapy has effectively controlled the mortality of tumors. Targeted therapy has the advantages of high selectivity and low toxicity, and can guide clinical medication for a long time. Its mechanism of action is to design a combination of drugs for the unique target of tumor cells, avoiding the shortcomings of traditional treatment methods, so as to achieve the goal of inhibiting tumor cell division and proliferation. For patients, it not only prolongs the survival time of patients, but also improves the quality of life of patients. [0003] At present, there are many genes related to tumor or cancer mutations that have been clinically identified, and when these genes are mutated, the sensitivity of cells ...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6886C12Q2600/156C12Q2600/166
Inventor 张鑫媛张春涛刘东来王海波
Owner GENE CRAB BIOTECH CO
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