A kind of recombinant human interferon ε vaginal expansion suppository and preparation method thereof

A technology of recombinant human interferon and vaginal expansion suppository, which is applied in the directions of drug combination, suppository delivery, pharmaceutical formulation, etc., can solve the problems of inability to exert the therapeutic effect of suppository, waste, and the contact area of ​​active ingredients is reduced, and achieves a significant HSV inhibitory effect. , the effect of reducing dosage, improving activity and stability

Active Publication Date: 2020-07-14
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recombinant human interferon α2b and its synergistic components are mixed and distributed in the matrix to form a drug-containing matrix. The contact area between the active ingredients and the human body is reduced and cannot be fully absorbed by the human body, resulting in a certain degree of waste. the best therapeutic effect of

Method used

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  • A kind of recombinant human interferon ε vaginal expansion suppository and preparation method thereof
  • A kind of recombinant human interferon ε vaginal expansion suppository and preparation method thereof
  • A kind of recombinant human interferon ε vaginal expansion suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050]

[0051] The preparation method is as follows:

[0052] (1) heating and melting the matrix in a water bath to obtain a melt;

[0053] (2) mixing each lactic acid bacteria and bifidobacterium evenly with the melt of step (1) to obtain a mixture;

[0054] (3) Pour the mixture described in step (2) into the plug mold, insert the expansion carrier, cool and set the shape, and obtain the matrix plug core;

[0055] (4) After fully mixing the recombinant human interferon ε and the traditional Chinese medicine composition, spray it on the surface of the matrix plug core described in step (3) in a spray form, and make a suppository after cooling down;

[0056] (5) The suppository in step (4) is added to a high molecular polymer, subjected to ultrasonication, and dried to obtain the vaginal expansion suppository.

Embodiment 2

[0058] Compared with Example 1, the components of the recombinant human interferon ε and the traditional Chinese medicine composition were adjusted, and the content of each component was the same as that of Example 1.

[0059]

[0060] The preparation method is the same as in Example 1.

Embodiment 3

[0062] Compared with Example 1, the components of the recombinant human interferon ε and the traditional Chinese medicine composition were adjusted, and the content of each component was the same as that of Example 1.

[0063]

[0064]

[0065] The preparation method is the same as in Example 1.

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Abstract

The invention provides a recombinant human interferon ε vaginal expansion suppository and a preparation method thereof. The vaginal expansion suppository comprises in parts by weight: 0.1-1.0 parts of recombinant human interferon ε, 10-50 parts of high molecular polymer, 50-200 parts of matrix and 100-500 parts of expansion carrier. The outer layer of the vaginal expansible suppository of the present invention is coated with a high molecular polymer, which effectively controls the release speed and release time of recombinant human interferon ε, so that the drug effect of the vaginal expansive suppository lasts up to 24 hours; The curative effect of recombinant human interferon ε was increased by 3-4 times with the combination of the extracts, the extract of Ziheche, the extract of wild lily and the extract of Scutellaria baicalensis.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, and relates to a vaginal expansion suppository and a preparation method thereof, in particular to a recombinant human interferon ε vaginal expansion suppository and a preparation method thereof. Background technique [0002] Recombinant human interferon ε is a kind of multifunctional and highly active induced protein obtained from Escherichia coli with high expression of human interferon ε gene through fermentation, isolation and high purification. It has significant broad-spectrum antiviral effect and immune regulation Function, has significant curative effect on human papillomavirus (HPV) infection diseases such as cervical erosion, condyloma acuminatum and cervical cancer, and has few side effects. At present, the dosage forms of recombinant human interferon ε are mainly tablets and suppositories, but recombinant human interferon ε is unstable, and the development of new dosage forms is di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K9/02A61K47/34A61P15/02A61P31/20A61K35/50A61K35/744A61K35/745A61K36/79A61K36/57
Inventor 邱明世
Owner 哈尔滨田美药业股份有限公司
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